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Nathan Goodyear

Do Stress Trajectories Predict Mortality in Older Men? Longitudinal Findings from the V... - 0 views

www.hindawi.com/...896109

stress mortality aging men

shared by Nathan Goodyear on 06 Sep 12 - No Cached
  • Nathan Goodyear on 06 Sep 12
     
    Stress increases mortality in older men.
Nathan Goodyear

A Healthy Body in a Healthy Mind-and Vice Versa-The Damaging Power of "Uncontrollable" ... - 0 views

jcem.endojournals.org/...1842.full

stress cortisol cancer health healthy wellness inflammation

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    very nice article on how stress causes inflammation and creates an unhealthy environment and thus a breeding ground for disease
Nathan Goodyear

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance ... - 0 views

www.sciencedirect.com/...S0092867408010088

chronic overnutrition NF-kappaB IKK-Beta inflammation obesity overweight weight-loss ER endoplasmic reticulum stress

shared by Nathan Goodyear on 17 Jan 12 - No Cached
  • Nathan Goodyear on 17 Jan 12
     
    chronic overnutrition (ie overeating) results in activation of the IKKBeta/NF-kappaB complex, increase NF-kappaB transcription and inflammation.  This leads to ER (endoplasmic reticulum) stress
Nathan Goodyear

Access : FFA-Induced Adipocyte Inflammation and Insulin Resistance: Involvement of ER S... - 0 views

www.nature.com/...oby2010200a.html

FFA inflammation overweight obesity free fatty acids insulin resistance IKK-Beta endoplasmic reticulum stress

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Nathan Goodyear on 21 Dec 11
     
    elevated FFA (free-fatty acids) shown to produce inflammation and insulin resistance through endoplasmic reticulum stress.  The main target in this pathway is IKK-Beta overexpression.
Nathan Goodyear

DASH Diet Lowers Blood Pressure and Lipid-Induced Oxidative Stress in Obesity - 0 views

hyper.ahajournals.org/...422.full

DASH diet dietary lifestyle changes oxidative stress inflammation IR insulin resistance obesity overweight HTN hypertension blood pressure

shared by Nathan Goodyear on 14 Jan 12 - No Cached
  • Nathan Goodyear on 14 Jan 12
     
    DASH diet shown to lower oxidative stress, inflammation, improve insulin resistance, lower inflammation, and aid weight loss.
Nathan Goodyear

Endoplasmic Reticulum Stress: Another Link Between Obesity and Insulin Resistance/Infla... - 0 views

diabetes.diabetesjournals.org/...518.full

endoplasmic reticulum stress obesity insulin resistance overweight weight-loss inflammation

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Nathan Goodyear on 21 Dec 11
     
    This article discusses how endoplasmic reticulum stress contributes to obesity.
Nathan Goodyear

Journal of Traumatic Stress, Volume 3, Number 3 - SpringerLink - 0 views

www.springerlink.com/...g0423r5415l48147

sleep disorder insomnia PTSD stress combat military

shared by Nathan Goodyear on 03 Jan 12 - No Cached
  • Nathan Goodyear on 03 Jan 12
     
    sleep disruption is a major symptom in those with PTSD.  There is no greater stress than combat.  The majority of research on PTSD is done on combat veterans
Nathan Goodyear

Does stress damage the brain? [Biol Psychiatry. 1999] - PubMed - NCBI - 1 views

www.ncbi.nlm.nih.gov/...10202566

stress hippocampus brain atrophy serotonin PTSD psychiatry damage

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    stress results in shrinkage of the hippocampus of the brain.  This would result in deficiency in serotonin and thus contribute to many of the symptoms found in those with PTSD.
Nathan Goodyear

Stress-induced hypocortisolemia diagnosed a... [Ann N Y Acad Sci. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16399913

cortisol adrenal stress hypocortisolemia low psychiatric condition

shared by Nathan Goodyear on 15 Nov 11 - Cached
  • Nathan Goodyear on 15 Nov 11
     
    Always remember to evaluate cortisol in post stress psychiatric disorders.  normallzation of cortisol can resolve psychiatric condition indicating that the underlying etiology is adrenal in nature.
Nathan Goodyear

Stress in obesity: cause or consequence? [Med Hypotheses. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21444159

stress obesity overweight weight-gain weight loss cortisol

shared by Nathan Goodyear on 10 Feb 12 - No Cached
  • Nathan Goodyear on 10 Feb 12
     
    stress and obesity.  An intimate connection.
Nathan Goodyear

Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response i... - 0 views

joe.endocrinology-journals.org/...207.abstract

bisphenol A Bisphenol-A BPA xenoestrogens stress hormone hormones

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Nathan Goodyear on 04 Feb 14
     
    intra uterine exposure to BPA disrupts stress response in rat model.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

www.jneurosci.org/...1448.long

DHT metabolite metabolites 3-beta androstanediol 3-beta-diol HPA stress ER estrogen receptor ER beta ER-beta hormone hormones

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Full article of previously posted abstract.  DHT metabolite 3beta-diol inhibits HPA stress response via ER beta.  
Nathan Goodyear

RB&E | Abstract | Levothyroxine and lung cancer in females: the importance of oxidative... - 0 views

www.rbej.com/...abstract

levothyroxine T4 lung cancer hypothyroid oxidative stress

shared by Nathan Goodyear on 22 Dec 13 - No Cached
  • Nathan Goodyear on 22 Dec 13
     
    Interesting study finds T4 therapy, levothyroxine,  linked to increased lung cancer.  The link could be through oxidative stress.
Nathan Goodyear

Peripheral oxidative stress in relapsing-remitting multiple sclerosis - 0 views

www.sciencedirect.com/...S0009912012000525

MS multiple sclerosis glutathione reduced oxidized perioxidase glutathione-S-transferase glutathione peroxidase GSH GSSG SOD GST 8OHdG 8-hydroxy-2-deoxyguanosine oxidative stress

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Nathan Goodyear on 19 Mar 14
     
    Relapsing remitting MS patients found to have in increased 8OHdG, reduced glutathione, reduced glutathione to oxidized glutathione ratio, super oxidized disumutase, glutathione reductase, and global oxidative stress.  In contrast, decreased total antioxidant capacity, oxidized glutathione, glutathione perioxidase, and glutathione transferase were found in relapsing remitting MS patients.
Nathan Goodyear

The stress response and the hypothalamic‐pituitary‐adrenal axis: from molecul... - 0 views

qjmed.oxfordjournals.org/...323.long

stress response HPA cortisol immune system inflammation inflammatory cytokines

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Good review of the interaction between the HPA stress response and the immune system.
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

cancer immune system NK cells NK natural killer cells innate

shared by Nathan Goodyear on 15 Jun 14 - No Cached
  • Nathan Goodyear on 15 Jun 14
     
    Stress decreases the innate immune response.  This is critical in the battle against cancer.  Specifically, low NK activity is found in stress individuals with cancer.
Nathan Goodyear

Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight su... - 0 views

www.ncbi.nlm.nih.gov/...21964877

astaxanthin MDA malondialdehyde oxidative stress SOD superoxide disumutase oxidized LDL LDL LDL cholesterol CVD

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    Astaxanthin at 20 mg found to reduce oxidized LDL and other oxidative stress biomarkers as assessed by Malondialdehydy, SOD, Isoprostane, and TAC.  The dose was 20 mg for 12 weeks. This higher dose was associated with minimal side effects--red stools.
Nathan Goodyear

Effects of astaxanthin on oxidative stress in overweight and obese adults. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21480416

oxidative stress astaxanthin malondialdehyde superoxide disumutase isoprostane

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    short study found that astaxanthin at 5 and 20 mg was associated with a reduction in oxidative stress biomarkers.
Nathan Goodyear

Chronic maternal stress inhibits the capacity to up-regulate placental 11beta-hydroxyst... - 0 views

www.ncbi.nlm.nih.gov/...16135661

11beta-HSD2 stress cortisol glucocorticoids

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    acute stress is associated with increased 11beta-HSD2 in pregnant rat model.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

www.jneurosci.org/...1448.full

DHT 3 beta androstanediol androgens Hypothalamus HPA hormones stress

shared by Nathan Goodyear on 15 Jul 15 - No Cached
  • Sex steroid hormones are primarily responsible for sex difference in adult HPA function; androgens inhibit whereas estrogens enhance HPA axis activation after a stressor
  • the PVN contains relatively high levels of AR (Bingaman et al., 1994; Zhou et al., 1994) and ERβ (Alves et al., 1998; Hrabovszky et al., 1998; Somponpun and Sladek, 2003) but is essentially devoid of ERα
  • the nonaromatizable androgen DHT and the nonselective ER ligand E2 influence HPA reactivity by acting on neurons within or surrounding the PVN
  • ...9 more annotations...
  • inhibitory action of DHT is detectable at both the level of hormone secretion as well as PVN c-fos mRNA expression
  • the inhibition can be mimicked by the DHT metabolite 3β-diol and by the subtype selective ERβ agonist DPN
  • E2 acts to enhance HPA reactivity
  • the ability of the ER antagonist tamoxifen, but not the AR antagonist flutamide, to block the inhibitory actions of DHT, speaks to the intracellular mechanism by which this inhibitory signal might be transduced.
    • Nathan Goodyear
      Nathan Goodyear on 15 Jul 15
       
      that is because the interaction with the DHT metabolite is not with the AR, but with the ER-beta.
  • the DHT metabolite 3β-diol and the ERβ-subtype-selective agonist DPN suppressed ACTH, corticosterone, and c-fos mRNA responses to restraint stress in a manner similar to DHT
  • metabolism of DHT to 3β-diol and subsequent binding to ERβ can be inhibitory to HPA reactivity, and this is one possible mechanism for the action of DHT.
  • Our data also suggest that E2 enhances the reactivity of the HPA axis to stress by acting on or near neurons of the PVN
  • the actions of E2 appear to be through an ERα-dependent mechanism
  • these studies suggest that ERβ, within the male hypothalamus, acts to inhibit the HPA axis and that the inhibitory effects of DHT may be, at least in part, via its intracellular conversion to 3β-diol and subsequent binding to ERβ
  • Nathan Goodyear on 15 Jul 15
     
    DHT metabolites: particularly 3beta-androstanediol inhibit HPA axis through ER-beta.
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