Skip to main content

Home/ Dr. Goodyear/ Group items tagged statin therapy

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

https://endo.confex.com/endo/2014endo/webprogram/Paper14285.html - 0 views

endo.confex.com/...Paper14285.html

statin statins statin therapy brain cognition metabolic syndrome metabolic syndrome memory

shared by Nathan Goodyear on 19 Jul 14 - No Cached
  • Nathan Goodyear on 19 Jul 14
     
    Statin use found to be associated with cognitive decline.  The authors defined use as long-term, though 2 years of use was found to be associated with decline.   interestingly, metabolic syndrome was not found to be associated with cognitive decline.
Nathan Goodyear

The Effect of Statin Therapy on Testosterone Levels in Subjects Consulting for Erectile... - 0 views

onlinelibrary.wiley.com/...full

Statins ED low Testosterone T

shared by Nathan Goodyear on 01 Jun 11 - No Cached
  • Nathan Goodyear on 01 Jun 11
     
    Statin therapy linked to ED through low Testosterone
Nathan Goodyear

Effects of Simvastatin and Oral Contraceptive Agent on Polycystic Ovary Syndrome: Prosp... - 0 views

jcem.endojournals.org/...456.full

simvastatin low T testosterone PCOS hyerplipidemia statins statin therapy

shared by Nathan Goodyear on 28 Oct 11 - No Cached
  • Nathan Goodyear on 28 Oct 11
     
    simvastatin, a cholesterol lowering drug, shown to decrease testosterone by 38% in women with PCOS. This supports what has been seen in men on statin therapy.
Nathan Goodyear

Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-... - 0 views

www.ncbi.nlm.nih.gov/...19100953

vitamin d statins muscle pain myalgia

shared by Nathan Goodyear on 24 Aug 15 - No Cached
  • Nathan Goodyear on 24 Aug 15
     
    vitamin D reduces muscle pain associated with statin therapy.
Nathan Goodyear

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy -... - 0 views

www.nejm.org/...NEJMoa1107579

niacin triglycerides HDL AIM-HIGH study cholesterol levels therapy

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    clients on statin therapy shown to have significant further decrease in triglycerides and increase in HDL in AIM-HIGH study.
Nathan Goodyear

The effect of statins on testosterone in men and wom... [BMC Med. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23448151

Testosterone statin statins statin therapy

shared by Nathan Goodyear on 14 Aug 14 - No Cached
  • Nathan Goodyear on 14 Aug 14
     
    Meta-analysis finds that Testosterone lowers Testosterone levels in both men and women.  I love the authors concluding remarks: "whether this is a detrimental side effect..."  in men, there is no doubt.
Nathan Goodyear

Atorvastatin treatment reduces exercise capac... [J Appl Physiol. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21852406

statin mitochondria energy ATP muscle damage performance exercise

shared by Nathan Goodyear on 16 Mar 12 - No Cached
  • Nathan Goodyear on 16 Mar 12
     
    statin therapy damages mitochondria. Mitochondria are the powerhouses of the cell: they are the energy producers of the cell.  It is no surprise that damage to the cells capacity to make energy will in turn decrease the capacity of muscle to perform.
Nathan Goodyear

Vitamin D deficiency, myositis-myalgia, an... [Curr Med Res Opin. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21728907

statin therapy vitamin D myalgia myositis muscle pain

shared by Nathan Goodyear on 25 Aug 11 - No Cached
  • Nathan Goodyear on 25 Aug 11
     
    vitamin D reduces incidence of statin induced muscle pain
Nathan Goodyear

Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and g... - 0 views

www.ncbi.nlm.nih.gov/...PMC4114109

statin statin therapy statins sperm men male fertility atorvastatin hormones

shared by Nathan Goodyear on 04 Sep 14 - No Cached
  • Nathan Goodyear on 04 Sep 14
     
    I really don't understand the purpose of this study.  Why give "healthy" men with normal lipids atorvastatin???  The study found a reduction in TC and LDL, but also a reduction in sperm number, decreased sperm vitality, increased sperm morphology, decreased prostatic acid pho sphatases, epididymal neutral alpha-glucosidase and L-carnitine levels resulted.  
Nathan Goodyear

ScienceDirect.com - Physiology & Behavior - Mitochondrial complex I inhibition depletes... - 0 views

www.sciencedirect.com/...S0031938404003403

testosterone mitochondria parkinson's disease Parkinson's

shared by Nathan Goodyear on 21 May 13 - No Cached
  • Nathan Goodyear on 21 May 13
     
    Testosterone is known to provide anti-inflammatory signaling in men.  This study, inhibition of mitochondrial complex I (coQ dependent) resulted in lower testosterone in rat models.  One of the major side effects of statin therapy is poor memory and brain fog. Hmmm.
Nathan Goodyear

Journal of Endocrinological Investigation - 0 views

www.jendocrinolinvest.it/...abstract.cfm

birth control oral contraceptives cardiovascular risk PCOS polycystic ovary syndrome

shared by Nathan Goodyear on 28 May 13 - No Cached
  • Nathan Goodyear on 28 May 13
     
    The point of this post is not that the author concludes that metformin an statin therapy should be used in PCOS women on birth control with elevated cardiovascular risk; but that with struggling with PCOS should have cardiovascular risk assessment prior to starting birth control.  Again, back to the individualized approach paradigm.
Nathan Goodyear

Cholesterol-lowering therapy and cell membranes. Stable plaque at the expense of unsta... - 0 views

www.lizscript.co.uk/...AMS01.pdf

cholesterol neurology brain neurodegenerative disease statins statin therapy

shared by Nathan Goodyear on 21 Jun 12 - No Cached
  • Nathan Goodyear on 21 Jun 12
     
    This article tells it all in the conclusion: "Changing our current practice pattern could take many years, but we may one day prescribe cholesterol-raising medications to certain patients". The long term effect of lowering cholesterol MAY stabilize plaques (not reduce), but at the expense of the brain. So, we may all have stable plaques, but we just won't know it because our brains will be fried.
Nathan Goodyear

Long-term Safety of Testosterone and Growth Hormone Supplementation: A Retrospective St... - 0 views

www.ncbi.nlm.nih.gov/...PMC3104655

hormones Testosterone growth GH hormone PSA cardiovascular male men

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    Retrospective study finds that 2 years of Testosterone and GH do not change metabolic biomarkers, PSA, or disease risk.  LDL and TC were in fact decreased in the study arm without statin therapy.
Nathan Goodyear

The Effect of Atorvastatin and Atorvastatin-Ezetimibe Combination T... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25350347

statin therapy statins PCOS polycystic ovarian syndrome androgens Testosterone women female hormone hormones

shared by Nathan Goodyear on 11 Nov 14 - No Cached
  • Nathan Goodyear on 11 Nov 14
     
    Cholesterol lowering drug, atorvastatin, lowers androgen levels in women with PCOS.  The same has been shown in men.
Nathan Goodyear

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who... - 0 views

www.ncbi.nlm.nih.gov/...15765890

statin statin therapy diabetes

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Only abstract available here, but atorvastatin associated with a reduction in cardiovascular events but also associated with increased risk of diabetes.
Nathan Goodyear

Nutrition Journal | Full text | Effects of coenzyme Q10 supplementation (300 ... - 0 views

www.nutritionj.com/...142

CoQ10 inflammation cytokines

shared by Nathan Goodyear on 19 Nov 13 - No Cached
Click Here . liked it
  • Nathan Goodyear on 19 Nov 13
     
    CoQ10 reduced inflammatory cytokines IL-6 and TNF-alpha.  CoQ10 also increased SOD, catalase, and glutathione perioxidase.  The duration of therapy was quite short--12 weeks.  The patients included in the study had pre-existing CAD.
  • Click Here . on 20 Nov 13
     
    study finds prolonged exposure to estrogen associated with increased colorectal cancer risk in postmenopausal women. So many unanswered questions. What was the ER status of these patients? What was the weight of these patients? One cannot simply compare estrogen exposure to colorectal cancer risk and say aha! What is the environment of the individual(s)?!Thanks visit; blog.hoop.la
Nathan Goodyear

A Review of the Rationale for Additional Therapeutic Interventions to Attain Lower LDL-... - 0 views

www.ncbi.nlm.nih.gov/...PMC3252497

natural cholesterol red yeast rice diet nutrition fiber niacin plant sterols

shared by Nathan Goodyear on 28 Aug 15 - No Cached
  • Nathan Goodyear on 28 Aug 15
     
    review of a few natural therapies to manage cholesterol.
Nathan Goodyear

Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 di... - 0 views

www.ajandrology.com/article.asp

Testosterone therapy diabetes lipids glucose triglycerides men male hormone hormones

shared by Nathan Goodyear on 17 Jan 14 - No Cached
  • up to 40% of men with T2DM have testosterone deficiency
  • Among diabetic patients, a reduction in sex hormone binding globulin levels induced by insulin resistance leads to a further decline of testosterone levels
  • low bioavailable testosterone concentration was related to decreased lean body mass and muscle strength
  • ...13 more annotations...
  • Testosterone deficiency has a high prevalence in men with T2DM, and it is also associated with impaired insulin sensitivity, increased percentage body fat, central obesity, dyslipidemia, hypertension and cardiovascular diseases (CVD)
  • A meta-analysis of four randomized controlled trials (RCTs) showed that TRT seemed to improve glycemic control as well as fat mass in T2DM subjects with low testosterone levels and sexual dysfunction.
  • testosterone administration could increase muscle mass and strength
  • Insulin stimulates glucose uptake into muscle and adipose tissue via the Glut4 glucose transporter isoform. When insulin activates signaling via the insulin receptor, Glut4 interacts with insulin receptor substrate 1 to initialize intracellular signaling and facilitate glucose transportation into the cell
  • The benefits of TRT on glucose metabolism can mainly be explained by its influence on the insulin signaling pathway
  • Insulin resistance as assessed by, which is calculated from the equation (If*Gf/22.5, where If is fasting insulin and Gf is fasting glucose), was definitely improved by TRT after testosterone administration in three studies
  • Testosterone was observed to elevate the expression levels and stimulate translocation of Glut4 in cultured skeletal muscle cells and to upregulate Glut4 by activating insulin receptor signaling pathways in neonatal rats
  • These effects were inhibited by a dihydrotestosterone (DHT) blocker, indicating that glucose uptake may correlate with conversion of testosterone to DHT and activation of the androgen receptor.
  • TRT reduced triglyceride levels
  • TRT has been reported to have a positive effect in the decrease of total and LDL cholesterol levels and triglycerides in hypogonadal men
  • a recent meta-analysis showed that statins could significantly lower testosterone concentrations.
  • Epidemiological studies have found a negative relationship between testosterone levels and typical cardiovascular risk markers, such as body mass index, waist circumference, visceral adiposity and carotid intima-media thickness.
  • Testosterone treatment was shown to raise hemoglobin, hematocrit and thromboxane, all of which might give rise to CVD
  • Nathan Goodyear on 17 Jan 14
     
    Low Testosterone is a very significant problem in men with type II Diabetes.  Estimated to reach 40%, likely much higher.  They based these estimates only on T levels and sexual symptoms. Testosterone improves glycemic control primarily through Increased transcription and transloction of GLUT4 insulin receptors to the cell surface.  Inflammation reduction is also a mechanism.  Testosteorne lowers Triglycerides in the traditional lipid profile.  Studies are mixed on the other aspects of  lipids.  
Nathan Goodyear

Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of stat... - 0 views

www.ncbi.nlm.nih.gov/...PMC2936758

Lp(a) lipoprotein(a) cardiovascular disease risk heart health

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Lp(a) found to highly correlate with obstructive coronary disease.
‹ Previous 21 - 40 of 40
Showing 20▼ items per page