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Nathan Goodyear

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis - 1 views

www.ncbi.nlm.nih.gov/...PMC3937164

sepsis IV vitamin C vitamin C CRP

shared by Nathan Goodyear on 11 Oct 17 - No Cached
  • Padayatty and colleagues showed that high-level ascorbic acid plasma concentrations could only be achieved by intravenous administration
  • No patient in the low or high dose ascorbic acid treatment arms of this study suffered any identifiable adverse event
  • a pharmacologic ascorbic acid treatment strategy in critically ill patients with severe sepsis appears to be safe
  • ...7 more annotations...
  • subnormal plasma ascorbic acid levels are a predictable feature in patients with severe sepsis
  • Ascorbic acid depletion in sepsis results from ascorbic acid consumption by the reduction of plasma free iron, ascorbic acid consumption by the scavenging of aqueous free radicals (peroxyl radicals), and by the destruction of the oxidized form of ascorbic acid dehydroascorbic acid
  • Sepsis further inhibits intracellular reduction of dehydroascorbic acid, producing acute intracellular ascorbic acid depletion
  • Ascorbic acid treated patients in this study exhibited rapid and sustained increases in plasma ascorbic acid levels using an intermittent every six hours administration protocol
  • Septic ascorbic acid-deficient neutrophils fail to undergo normal apoptosis. Rather, they undergo necrosis thereby releasing hydrolytic enzymes in tissue beds, thus contributing to organ injury
  • We speculate that intravenous ascorbic acid acts to restore neutrophil ascorbic acid levels
  • Repletion of ascorbic acid in this way allows for normal apoptosis, thus, preventing the release of organ damaging hydrolytic enzymes.
  • Nathan Goodyear on 11 Oct 17
     
    Study finds IV vitamin C in patients with sepsis is very safe and blunts the effects (endothelial damage, end organ damage...) of sepsis.  Of note, the IV vitamin C group reached serum levels of ascorbic acid of 1,592 to 5,722 micromol/L.  The IV groups maintained elevated serum C levels for up to 96 hours post infusion.  
Nathan Goodyear

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a p... - 0 views

www.ncbi.nlm.nih.gov/...PMC1224653

IV vitamin C vitamin C intravenous alternative Intravenous vitamin C vitamin C cancer H2O2 ascorbic acid

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    IV vitamin C and IV vitamin C only can deliver levels to tumor cells that induce formation of H2O2 that then induces cell death.
Nathan Goodyear

JTM | Full text | Effect of high-dose intravenous vitamin C on inflammation in cancer p... - 0 views

www.translational-medicine.com/...189

inflammation cancer IV vitamin C intravenous vitamin C vitamin C vitamin C

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    high dose IV vitamin C shown to reduce inflammatory and tumor markers in cancer patients.
Nathan Goodyear

PLoS ONE: Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practiti... - 0 views

www.plosone.org/...journal.pone.0011414

vitamin C IV therapy

shared by Nathan Goodyear on 27 Sep 11 - No Cached
  • high dose intravenous vitamin C appears to be remarkably safe
  • Nathan Goodyear on 27 Sep 11
     
    IV vitamin C therapy is a safe delivery route for high dose vitamin C
Nathan Goodyear

Effect of high dose vitamin C on Epstein-Barr viral infection - 0 views

www.ncbi.nlm.nih.gov/...PMC4015650

IVC IV intravenous vitamin C IV vitamin C intravenous vitamin C vitamin C Epstein-Barr Epstein-Barr virus EBV viral infection

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    IV vitamin C shown to reduce EBV EA IgG and EBV VCA IgM using 7.5 grams to 50 gram infusions.  This protocol found that Magnesium reduced discomfort with the IVC therapy.
Nathan Goodyear

False Positive finger stick blood glucose readings after high-dose intravenous vitamin C - 0 views

www.riordanclinic.org/...89024578.pdf

IV vitamin C vitamin C glucose vitamin C

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    IV vitamin C > 15 grams falsely elevates finger sticks on glucose. Glucose and vitamin C are very similar chemically. This, however, is a false reading.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.1002/hep.21080/asset/21080_ftp.pdf;jsessionid=C... - 0 views

onlinelibrary.wiley.com/...FD1E43279D6DC7447C7FC1A.f04t01

vitamin C IV vitamin C IV intravenous cirrhosis

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    small study looked at patients with liver cirrhosis.  The authors used a low dose of IV vitamin C (5 grams) and found that this improved endothelial dysfunction.  Patients with cirrhosis were found to be low in vitamin C.  The IV vitamin C was well tolerated, despite a low dose.
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases -- Padayatty et al.... - 0 views

www.cmaj.ca/...937

intravenously vitamin C cancer

shared by Nathan Goodyear on 09 Feb 11 - Cached
  • high-dose vitamin C, given by intravenous and oral routes, may improve symptoms and prolong life in patients with terminal cancer
  • Nathan Goodyear on 09 Feb 11
     
    High-dose IV vitamin C benefits cancer patients:review of 3 case studies
Nathan Goodyear

Acute Hepatitis Treated with High Doses of Vitamin C - 0 views

www.seanet.com/...hio_st_med_j-1960-v56-p821.htm

HCV Hepatitis C hepatitis IV vitamin C vitamin C Intravenous vitamin C vitamin C

shared by Nathan Goodyear on 26 Aug 14 - Cached
  • Nathan Goodyear on 26 Aug 14
     
    Old case study of IV vitamin C, not high dose, used to treat acute case of hepatitis C.
Nathan Goodyear

The Beneficial Effects of Antioxidant Supplementation in Enteral Feeding in Critically ... - 0 views

www.anesthesia-analgesia.org/...857.long

IV intravenous vitamin C E critically ill sepsis antioxidant therapy treatment

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    IV vitamin C and vitamin E was found to lower the mortality rate in those with critical illness at the 28 day mark.  This study showed the safety and efficacy of IV vitamin C and vitamin E in those critically ill.
Nathan Goodyear

European Journal of Clinical Nutrition - C-reactive protein concentration and concentra... - 0 views

www.nature.com/...1601667a.html

IV vitamin C intravenous IV vitamin C antioxidants CRP ROS vitamins

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    This study shows that inflammation, CRP in this study, was inversely associated with low antioxidants ie. vitamin C.  This makes since as ROS are known to stimulate inflammation.  Vitamin C should be considered as a therapeutic option in those with inflammation.
Nathan Goodyear

High-dose intravenous vitamin C in the treatment of a patient with renal cell carcinoma... - 0 views

www.riordanclinic.org/...89023775_jom.pdf

IV vitamin C vitamin C IVC IV vitamin C intravenous cancer

shared by Nathan Goodyear on 29 May 13 - No Cached
  • Nathan Goodyear on 29 May 13
     
    This is a case study of a patient with cancer of the kidney treated with vitamin C. Therapy was obviously successive in obtaining remission.
Nathan Goodyear

Clinical and experimental experiences with intravenous vitamin C - 0 views

orthomolecular.org/...2000-v15n04-p201.pdf

cancer IV vitamin C vitamin C IV vitamin C intravenous

shared by Nathan Goodyear on 29 May 13 - No Cached
  • Nathan Goodyear on 29 May 13
     
    Nice review of the cytotoxicity of malignant cells with IV vitamin C.
Nathan Goodyear

Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients... - 0 views

iv.iiarjournals.org/...983.abstract

vitamin C IV intravenous therapy treatment cancer

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    IV vitamin C shown to improve quality of life measures in breast cancer patients during chemo/radiation.  What this shows, is that IV vitamin C is not only safe for healthy individuals, but healthy for cancer patients.
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases - 0 views

www.cmaj.ca/...937.full

IV vitamin C intravenous therapy treatment cancer

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    high dose IV vitamin C therapy shown to benefit patients with cancer.  Three cases documented vitamin C therapy in patients with cancer
Nathan Goodyear

Researchers establish benefits of high-dose vitamin C for ovarian cancer patients - 0 views

www.kumc.edu/...corbate-with-chemotherapy.html

IV vitamin C vitamin C vitamin C cancer ovarian intravenous

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    statement from KU on their new study on IV vitamin C in stage III and IV ovarian cancer.
Nathan Goodyear

Intravenous vitamin C administration improve... [In Vivo. 2011 Nov-Dec] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22021693

IV vitamin C intravenous cancer

shared by Nathan Goodyear on 18 Sep 13 - No Cached
  • Nathan Goodyear on 18 Sep 13
     
    IV vitamin C in women with breast CA in Germany found to benefit from less side effects and improved quality of life in those receiving chemo/radiation.  Again, IV vitamin C proven to be well tolerated in very ill individuals.
Nathan Goodyear

Pharmacological ascorbate induces cytotoxic... [Anticancer Drugs. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22205155

vitamin C vitamin C cancer prostate cancer prostate IV vitamin C intravenous vitamin C IV intravenous ascorbic acid

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    IV vitamin C induces cell death of prostate cancer cell lines via H2O2, which is not new, but what is new is the ascorbate-insensitive cell line.
Nathan Goodyear

MECHANISMS OF ASCORBATE-INDUCED CYTOTOXICITY IN PANCREATIC CANCER - 0 views

www.ncbi.nlm.nih.gov/...PMC2807999

pancreatic cancer cancer IV vitamin C intravenous vitamin C vitamin C IV vitamin C intravenous alternative

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Good discussion of the mechanism of action of IV vitamin C in cancer therapy.
Nathan Goodyear

Increasing the Effectiveness of Intravenous Vitamin C as an Anticancer Agent - ISOM - 0 views

www.isom.ca/...tamin-c-as-an-anticancer-agent

vitamin C "IV vitamin C" ozone cancer immunotherapy

shared by Nathan Goodyear on 16 May 17 - No Cached
  • Nathan Goodyear on 16 May 17
     
    Good review of ways to increase the anti-cancer efficacy of IV vitamin C.
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