IV glutathione shown to be same and provide mild improvement in Parkinson's disease. This is a small pilot study, but a good place to start. The likelyhood is that glutathione is more beneficial early in Parkinson's disease to slow disease progression.
IV vitamin C, though low dose, is associated with a reduced myocardial injury. Not only safe, but benefit is seen in protecting the heart against repercussion injury.
ur data showed that sHT patients exists impaired endothelial function, and antioxidant alpha-lipoic acid can improve endothelial function, through decrease of oxygen- derived free radicals.
when vitamin
C is ingested by mouth, plasma and tissue concentrations are tightly controlled by at least 3 mechanisms in healthy humans:
absorption, tissue accumulation, and renal reabsorption
4th mechanism, rate of utilization, may be important in disease
Ascorbate administered intravenously has already been tested in a phase I clinical trial, is in wide use
by complementary and alternative medicine (integrative medicine) practitioners, and appears to have minimal side effects in
patients who are properly screened.
vitamin C effects decreased by hypoxia which increases HIF-1alpha. The authors propose oxygen therapy, hyperbaric, to improve and augment the cytotoxic effects of vitamin C.