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In spite of being a minor cellular subset, cancer stem cells (CSCs) fundamentally contribute to intra-tumor heterogeneity. With the biological features of self-renewal and differentiation, CSCs confer a driving force for malignant recurrence and anti-cancer drug resistance in oncologic patients, which highlight an unmet clinical need calling for innovative medicine to Come up. Due to the elusiveness of specific biomarkers and biological regulation for CSCs, a number of precisely targeted therapeutic approaches against CSCs are at their infancy far from reaching the clinic. However, we have herein been able to sort out three groups of CSC inhibitors which are clinically available, and proposed to take the advantages of these drugs to improve the therapeutic efficacy of existing anti-cancer treatments. For more info : http://scidoc.org/JBR-TCEO-01-201.php

Nanomedicine is an application of nanotechnology which made its debut with greatly increased possibilities in the field of medicine. Nanomedicine desires to deliver research tools and clinically reformative devices in the near future. With the advance of nanomedicine technology, scientists face a new realm in biotherapeutics and drug development that includes vaccines, antibodies, gene therapies and Nanoparticles such as liposomes, polymeric micelles, Nanoparticles, dendrimers, and nanocrystals for drug delivery and contrast agents. For more info : http://scidoc.org/IJNSTSpecialIssues.php

International Journal of Clinical Pharmacology & Toxicology (IJCPT) ISSN:2167-910X aims to develop coherent means to modify drug therapy, with respect to the patients genotype, and to ensure maximum efficiency with minimal contrary effects. Clinical Pharmacology & Toxicology is the all-encompassing and becoming an increasingly important discipline for the identification of disease targets and drug designing with their toxicological effects and means to eradicate diseases. For more details : http://scidoc.org/clinical-pharmacology-and-toxicology.php

The epidemic of Zika Virus (ZV) drastically affected the health of more than one million people in Brazil resulting in twenty-fold increase of microcephaly (head circumference of newborn baby being less than or equal to thirty-two cms) in infected pregnant women. ZV crosses the placental barrier between maternal and fetal compartments. ZV has been found in amniotic fluid and fetal brain tissue of the human pregnancies complicated with ZV infection and microcephaly supporting cause and effect relationship between ZV and microcephaly. New knowledge about how ZV enters into the cells is mandatory for preventive and therapeutic research. ZV is a Flavivirus, therefore the Flavivirus receptors are candidate receptors for ZV too. ZV has been associated with high level of TYRO3 and AXL component of TAM, a Tyrosine Kinase receptor family, expression in the infected skin cells and neuronal stem cells. It predicts that AXL receptors may facilitate ZV entry into the trophoblasts and endothelial cells lining the fetal vessels present in the placenta. This hypothesis stems from the reported studies on ZV and AXL receptor expression, both in human tissues and animal models. If our hypothesis proves to be valid, it would be a great step towards the drug and therapeutic development to prevent ZV crossing the placental barrier and resulting in complications. For more info : http://scidoc.org/IJVR-03-401.php

JBR Journal of Translational Biomarkers & Diagnosis (JBR-TBD) is a peer-reviewed, Open Access journal. It is an official journal of JBR Health education and Research society, that publishes high quality papers such as - original research articles, review articles, rapid communications, case reports and clinical studies in all areas of Translational biomarkers and its related fields.

JBR Journal of Translational Diagnostics and Technology (JBR-JTDT) is a peer-reviewed, Open Access journal.It is an official journal of JBR Health education and Research society, that publishes high quality papers such as - original research articles, review articles, rapid communications, case reports and clinical studies in all areas of Translational diagnostics and its related fields. For more details :http://scidoc.org/translational-diagnostics-and-technology.php