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How Our Brain Balances Old and New Skills - 0 views

  • To learn new motor skills, the brain must be plastic: able to rapidly change the strengths of connections between neurons, forming new patterns that accomplish a particular task
  • if the brain were too plastic, previously learned skills would be lost too easily.
  • A new computational model developed by MIT neuroscientists explains how the brain maintains the balance between plasticity and stability
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  • and how it can learn very similar tasks without interference between them.
  • The key
  • is that neurons are constantly changing their connections with other neurons
  • not all of the changes are functionally relevant - they simply allow the brain to explore many possible ways to execute a certain skill, such as a new tennis stroke
  • As the brain learns a new motor skill, neurons form circuits that can produce the desired output
  • according to this theory
  • As the brain explores different solutions, neurons can become specialized for specific tasks
  • brain is always trying to find the configurations that balance everything so you can do two tasks, or three tasks, or however many you're learning
  • Perfection is usually not achieved on the first try, so feedback from each effort helps the brain to find better solutions
  • complications arise when the brain is trying to learn many different skills at once
  • Because the same distributed network controls related motor tasks, new modifications to existing patterns can interfere with previously learned skills.
  • particularly tricky when you're learning very similar things
  • such as two different tennis strokes
  • computer chip,
  • instructions for each task would be stored in a different location on the chip.
  • the brain is not organized like a computer chip. Instead, it is massively parallel and highly connected - each neuron connects to, on average, about 10,000 other neurons
  • That connectivity offers an advantage, however, because it allows the brain to test out so many possible solutions to achieve combinations of tasks
  • neurons
  • have a very low signal to noise ratio, meaning that they receive about as much useless information as useful input from their neighbors
  • The constant changes in these connections,
  • researchers call hyperplasticity
  • balanced by another inherent trait of
  • Most models of neural activity don't include noise, but the MIT team says noise is a critical element of the brain's learning ability
  • This model helps to explain how the brain can learn new things without unlearning previously acquired skills
  • the paper shows is that, counterintuitively, if you have neural networks and they have a high level of random noise, that actually helps instead of hindering the stability problem
  • Without noise, the brain's hyperplasticity would overwrite existing memories too easily
  • low plasticity would not allow any new skills to be learned, because the tiny changes in connectivity would be drowned out by all of the inherent noise
  • The constantly changing connections explain why skills can be forgotten unless they are practiced often, especially if they overlap with other routinely performed tasks
  • skills such as riding a bicycle, which is not very similar to other common skills, are retained more easily
  • Once you've learned something, if it doesn't overlap or intersect with other skills, you will forget it but so slowly that it's essentially permanent
  • researchers are now investigating whether this type of model could also explain how the brain forms memories of events, as well as motor skills
Mars Base

Researchers discover link between fear, sound perception - 0 views

  • our emotions can actually affect how we hear and process sound
  • When certain types of sounds become associated in our brains with strong emotions, hearing similar sounds can evoke those same feelings
  • a phenomenon commonly seen in combat veterans suffering from post-traumatic stress disorder (PTSD)
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  • a pair of researchers
  • has discovered how fear can actually increase or decrease the ability to discriminate among sounds depending on context
  • study
  • emotional conditioning in mice to investigate how hearing acuity (the ability to distinguish between tones of different frequencies) can change following a traumatic event, known as emotional learning
  • In these experiments
  • animals learn to distinguish between potentially dangerous and safe sounds—called "emotional discrimination learning."
  • This type of conditioning tends to result in relatively poor learning, but
  • designed a series of learning tasks intended to create progressively greater emotional discrimination in the mice, varying the difficulty of the
  • The researchers found that, as expected, fine emotional learning tasks produced greater learning specificity than tests in which the tones were farther apart in frequency
  • animals presented with sounds that were very far apart generalize the fear that they developed to the danger tone over a whole range of frequencies
  • animals presented with the two sounds that were very similar exhibited specialization of their emotional response
  • pitch discrimination abilities were measured in the animals, the mice with more specific responses displayed much finer auditory acuity than the mice who were frightened by a broader range of frequencies
  • Another interesting finding of this study is that the effects of emotional learning on hearing perception were mediated by a specific brain region, the auditory cortex
  • The auditory cortex has been known as an important area responsible for auditory plasticity
  • Surprisingly
  • found that the auditory cortex did not play a role in emotional learning
  • the specificity of emotional learning is controlled by the amygdala and sub-cortical auditory areas
  • hypothesis is that the amygdala and cortex are modifying subcortical auditory processing areas. The sensory cortex is responsible for the changes in frequency discrimination, but it's not necessary for developing specialized or generalized emotional responses
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Heavily decorated classrooms disrupt attention and learning in young children -- Scienc... - 0 views

  • materials tend to cover elementary classroom wall
  • new research from Carnegie Mellon University shows that too much
  • may end up disrupting attention and learning in young children
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  • whether classroom displays affected children's ability to maintain focus during instruction and to learn the lesson content
  • They found that children in highly decorated classrooms were more distracted, spent more time off-task and demonstrated smaller learning gains than when the decorations were removed
  • a classroom's visual environment can affect how much children learn
  • do not suggest by any means that this is the answer to all educational problems
  • additional research is needed to know what effect the classroom visual environment has on children's attention and learning in real classrooms
  • consider whether some of their visual displays may be distracting
  • 24 kindergarten students were placed in laboratory classrooms for six introductory science lessons on topics they were unfamiliar with
  • Three lessons were taught in a heavily decorated classroom, and three lessons were given in a sparse classroom.
  • results showed that while children learned in both classroom types, they learned more when the room was not heavily decorated
  • children's accuracy on the test questions was higher in the sparse classroom(55 percent correct) than in the decorated classroom(42 percent correct).
  • when the researchers tallied all of the time children spent off-task in both types of classrooms, the rate of off-task behavior was higher in the decorated classroom (38.6 percent time spent off-task) than in the sparse classroom (28.4 percent time spent off-task)
  • also interested in finding out if the visual displays were removed, whether the children's attention would shift to another distraction
  •  
    Heavily decorated classrooms disrupt attention and learning in young children
Mars Base

Online Game on How Earth's Moon Formed Nabs Honors | Space.com - 0 views

  • An online game that allows players to build their own moon and sculpt its features has won big praise in science art competition
  • "Selene: A Lunar Construction GaME,"
  • measures how and when players learn as they discover more about how the Earth's moon formed
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  • by extension, the solar system.
  • received an honorable mention in the 2012 International Science & Engineering Visualization Challenge
  • When they look at the moon, players are seeing what actually created those features
  • It makes moon observations more meaningful
  • Named for the Greek goddess of the moon, Selene works in two parts
  • In the first round, players aim asteroids of varying sizes, densities, and radiations so that they collide with one an
  • Too much force, and the rocks ricochet off one another
  • even if you overshoot your target, the gravity of the growing moon may tug just enough to pull the new piece into the pack
  • participants a chance to watch accretion in action
  • developing moon is constantly compared to the real-life one, and players strive to make as close a match as possible
  • After all of the small asteroids have melted together to form a smooth new moon, it's time to scratch up the surface
  • Players can aim asteroids of varying sizes at the body, and select areas where lava breaks through the crust
  • Because the accretion and surface-sculpting processes for the moon echo that of the rest of the planets, players also develop an understanding of how the early solar system formed
  • kids ages nine and up engage in the game, they build concrete knowledge that can be applied into any learning environment that they later experience, a process that serves to make learning more intuitive
  • Though the game is effective for high school and college students, and slanted to match the national standards for those age ranges
  • was more attractive to middle school students
  • One of the primary goals of Selene is to allow
  • team to analyze the learning process
  • means the game requires a login, and for minors, parental permission must be given.
  • analyzation takes time
  • able to provide a quick overview of my game play
  • can tell from looking at your data what your experiences were
  • That under-the-hood ability to study learning is why the project was so attractive in terms of funding to NASA and the National Science Foundation
  • d a prototype of the game was developed by CyGaMEs in May of 2007.
  • first version was released in 2010. But the game is constantly being improved as the understanding of the learning process grows
  • also looking at expanding it to mobile platforms in the near future.
  • recognition is of course a great honor and encouragement — but more importantly, may drive more players to the website so that we can collect more data
  • More players, of course, means more information that can be gathered about how participants learn
  • At the same time, more people can learn about how the moon formed, growing their understanding of the nearest celestial body.
  • http://selene.cet.edu/
Mars Base

Study shows how bilinguals switch between languages - 0 views

  • Individuals who learn two languages at an early age seem to switch back and forth between separate "sound systems" for each language, according to new research
  • The research
  • addresses enduring questions in bilingual studies about how bilingual speakers hear and process sound in two different languages.
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  • "A lot of research has shown that bilinguals are pretty good at accommodating speech variation across languages, but there's been a debate as to how,"
  • lead author Kalim Gonzales, a psychology doctoral student at the University of Arizona
  • two views: One is that bilinguals have different processing modes for their two languages—they have a mode for processing speech in one language and then a mode for processing speech in the other language
  • Another view is that bilinguals just adjust to speech variation by recalibrating to the unique acoustic properties of each language."
  • Gonzales's research supports the first view—that bilinguals who learn two languages early in life learn two separate processing modes, or "sound systems
  • The study looked at 32 Spanish-English early bilinguals, who had learned their second language before age 8.
  • Participants were presented with a series of pseudo-words beginning with a 'pa' or a 'ba' sound and asked to identify which of the two sounds they heard
  • 'pa' and 'ba' sounds exist in both English and Spanish, how those sounds are produced and perceived in the two languages varies subtly
  • 'ba,' for example, English speakers typically begin to vibrate their vocal chords the moment they open their lips
  • Spanish speakers begin vocal chord vibration slightly before they open their lips and produce 'pa' in a manner similar to English 'ba.'
  • English-only speakers might, in some cases, confuse the 'ba' and 'pa' sounds they hear in Spanish
  • most people think about differences between languages
  • different words and they have different grammars
  • at their base languages use different sounds
  • One of the reasons it sounds different when you hear someone speaking a different language is because the actual sounds they use are different
  • someone might sound like they have an accent if they learn Spanish first is because their 'pa' is like an English 'ba,' so when they say a word with 'pa,' it will sound like a 'ba' to an English monolingual
  • For the study, the bilingual participants were divided into two groups. One group was told they would be hearing rare words in Spanish, while the other was told they would be hearing rare words in English
  • Both groups heard audio recordings of variations of the same two words—bafri and pafri—which are not real words in either language
  • Each group heard the same series of words, but for the group told they were hearing Spanish, the ends of the words were pronounced slightly differently, with the 'r' getting a Spanish pronunciation
  • Participants perceived 'ba' and 'pa' sounds differently depending on whether they were told they were hearing Spanish words, with the Spanish pronunciation of 'r,' or whether they were told they were hearing English words, with the English pronunciation of 'r.'
  • when you put people in English mode, they actually would act like English speakers, and then if you put them in Spanish mode, they would switch to acting like Spanish speakers
  • hearing the exact same 'ba's and 'pa's would label them differently depending on the context
  • When the study was repeated with 32 English monolinguals, participants did not show the same shift in perception; they labeled 'ba' and 'pa' sounds the same way regardless of which language they were told they were hearing
  • that lack of an effect
  • provided the strongest evidence for two sound systems in bilinguals
  • true primarily for those who learn two languages very young
  • If you learn a second language later in life, you usually have a dominant language and then you try to use that sounds system for the other language, which is why you end up having an accent
Mars Base

Learning high-performance tasks with no conscious effort may soon be possible (w/ video) - 0 views

  • New research published today in the journal Science suggests it may be possible to use brain technology to learn to play a piano, reduce mental stress or hit a curve ball with little or no conscious effort
  • Japan, recently demonstrated that through a person's visual cortex, researchers could use decoded functional magnetic resonance imaging (fMRI) to induce brain activity patterns to match a previously known target state and thereby improve performance on visual tasks
  • Think of a person watching a computer screen and
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  • brain patterns modified to match those of a high-performing athlete
  • or modified to recuperate from an accident or disease
  • pictures gradually build up inside a person's brain, appearing first as lines, edges, shapes, colors and motion in early visual areas
  • The brain then fills in greater detail
  • none of these studies directly addressed the question of whether early visual areas are sufficiently plastic to cause visual perceptual learning
  • Until now.
  • implemented a method using decoded fMRI neurofeedback to induce a particular activation pattern in targeted early visual areas that corresponded to a pattern evoked by a specific visual feature in a brain region of interest
  • is a novel learning approach sufficient to cause long-lasting improvement in tasks that require visual performance
  • the approached worked even when test subjects were not aware of what they were learning
  • the decoded neurofeedback method might be used for various types of learning, including memory, motor and rehabilitation
  • this study we confirmed the validity of our method only in visual perceptual learning
Mars Base

Study gives new meaning to 'let your fingers do the walking' - 0 views

  • conclusion of a study conducted by a team of cognitive psychologists
  • When you are typing away at your computer, you don't know what your fingers are really doing
  • It found that skilled typists can't identify the positions of many of the keys on the QWERTY keyboard and that novice typists don't appear to learn key locations in the first place
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  • we're capable of doing extremely complicated things without knowing explicitly what we are doing
  • The researchers recruited 100 university students and members from the surrounding community to participate in an experiment
  • The participants completed a short typing test
  • Then, they were shown a blank QWERTY keyboard and given 80 seconds to write the letters in the correct location
  • On average, they typed 72 words per minute, moving their fingers to the correct keys six times per second with 94 percent accuracy
  • By contrast, they could accurately place an average of only 15 letters on a blank keyboard.
  • The fact that the typists did so poorly at identifying the position of specific keys didn't come as a surprise
  • For more than a century, scientists have recognized the existence of automatism: the ability to perform actions without conscious thought or intention
  • Automatic behaviors of this type are surprisingly common, ranging from tying shoelaces to making coffee to factory assembly-line work to riding a bicycle and driving a car
  • What did come as a surprise, however, was evidence that conflicts with the basic theory of automatic learning which holds that it starts out as a conscious process and gradually becomes unconscious with repetition
  • According to the widely held theory, when you perform a new task or the first time, you are conscious of each action and store the details in working memory
  • Then, as you repeat the task, it becomes increasingly automatic
  • This allows you to think about other things while you performing the task but your conscious recollection of the details gradually fades away
  • researchers were surprised when they found evidence that the typists never appear to memorize the key positions, not even when they are first learning to type.
  • Evidence for this conclusion came from another experiment included in the study
  • The researchers recruited 24 typists who were skilled on the QWERTY keyboard and had them learn to type on a Dvorak keyboard, which places keys in different locations.
  • After the participants developed a reasonable proficiency with the alternative keyboard, they were asked to identify the placement of the keys on a blank Dvorak keyboard
  • On average, they could locate only 17 letters correctly, comparable to participants' performance with the QWERTY keyboard.
  • According to the researchers, the lack of explicit knowledge of the keyboard may be due to the fact that computers and keyboards have become so ubiquitous that students learn how to use them in an informal, trial-and-error fashion when they are very young
Mars Base

Scientists reverse memory loss in animal brain cells - 0 views

  • Using sea snail nerve cells, the scientists reversed memory loss by determining when the cells were primed for learning
  • scientists were able to help the cells compensate for memory loss by retraining them through the use of optimized training schedules
  • study builds on
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  • 2012 investigation that pioneered this memory enhancement strategy
  • The 2012 study showed a significant increase in long-term memory in healthy sea snails
  • study's co-lead author and a research scientist
  • has developed a sophisticated mathematical model that can predict when the biochemical processes in the snail's brain are primed for learning
  • model is based on five training sessions scheduled at different time intervals ranging from 5 to 50 minutes
  • can generate 10,000 different schedules and identify the schedule most attuned to optimum learning
  • Memory is due to a change in the strength of the connections among neurons. In many diseases associated with memory deficits, the change is blocked
  • senior research scientist
  • simulated a brain disorder in a cell culture by taking sensory cells from the sea snails and blocking the activity of a gene that produces a memory protein
  • This resulted in a significant impairment in the strength of the neurons' connections, which is responsible for long-term memory
  • To mimic training sessions, cells were administered a chemical at intervals prescribed by the mathematical model
  • After five training sessions, which like the earlier study were at irregular intervals, the strength of the connections returned to near normal in the impaired cells
  • This methodology may apply to humans if we can identify the same biochemical processes in humans
  • results suggest a new strategy for treatments of cognitive impairment
  • Mathematical models might help design therapies that optimize the combination of training protocols with traditional drug treatments
  • Combining these two could enhance
  • effectiveness
  • while compensating at least in part for any limitations or undesirable side effects of drugs
  • two approaches are likely to be more effective together than separately and may have broad generalities in treating individuals with learning and memory deficits."
Mars Base

Prospective Alzheimer's drug builds new brain cell connections - 0 views

  • researchers have developed a new drug candidate that dramatically improves the cognitive function of rats with Alzheimer's-like mental impairment
  • intended to repair brain damage that has already occurred
  • This is about recovering function
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  • t makes these things totally unique. They're not designed necessarily to stop anything. They're designed to fix what's broken. As far as we can see, they work
  • current Alzheimer's treatments, which either slow the process of cell death or inhibit cholinesterase, an enzyme believed to break down a key neurotransmitter involved in learning and memory development
  • Last month, the Pharmaceutical Research and Manufacturers of America, or PhRMA, reported that only three of 104 possible treatments have been approved in the past 13 years
  • Development of the WSU drug is only starting
  • Safety testing alone could cost more than $1 million
  • been working on their compound since 1992
  • practical utility of these early drug candidates, however, was severely limited
  • they were very quickly broken down by the body and couldn't get across the blood-brain barrier,
  • cellular barrier that prevents drugs and other molecules from entering the brain
  • 'That's useless. I mean, who wants to drill holes in people's heads?
  • designed a smaller version of the molecule
  • Not only is it stable but it can cross the blood-brain barrier
  • added bonus is it can move from the gut into the blood, so it can be taken in pill form
  • reported similar but less dramatic results in a smaller group of old rats. In this study the old rats
  • tested the drug on several dozen rats treated with scopolamine, a chemical that interferes with a neurotransmitter critical to learning and memory.
  • a rat treated with scopolamine will never learn the location of a submerged platform in a water tank, orienting with cues outside the tank
  • After receiving the WSU drug, however, all of the rats did, whether they received the drug directly in the brain, orally, or through an injection.
  • statistically valid, additional studies with larger test groups will be necessary to fully confirm the finding.
  • bench assays using living nerve cells to monitor new neuronal connections
  • Dihexa to be seven orders of magnitude more powerful than BDNF, which has yet to be effectively developed for therapeutic use
Mars Base

British researchers create robot that can learn simple words by conversing with humans ... - 0 views

  • In an attempt to replicate the early experiences of infants, researchers in England have created a robot that can learn simple words in minutes just by having a conversation with a human.
  • three-foot-tall robot, named DeeChee, was built to produce any syllable in the English language. But it knew no words at the outset of the study, speaking only babble phrases like "een rain rain mahdl kross."
  • human volunteer attempted to teach the robot simple words for shapes and colors by using them repeatedly in regular speech.
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  • At first, all DeeChee could comprehend was an unsegmented stream of sounds
  • had been programmed to break up that stream into individual syllables and to store them in its memory
  • words were ranked according to how often they came up in conversation
  • words like "red" and "green" were prized.
  • designed to recognize words of encouragement, like "good" and "well done,"
  • That feedback helped transform the robot's babble into coherent words, sometimes in as little as two minutes.
  • repetition of sounds helps infants learn a language, then it's not surprising that our first words are often mainstays like "mama" and "dada."
  • words that form the connective tissue of our language - words like "at," "with" and "of" - are spoken in hundreds of different ways, making them difficult for newbies to recognize
  • more concrete words like "house" or "blue" tend to be spoken in the same way nearly every time
  • study relied on the human volunteers speaking naturally
  • DeeChee was programmed to smile when it was ready to pay attention to its teacher and to stop smiling and blink when it needed a break
  • designed to have a gender-neutral appearance, humans tended to treat it as a boy
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Psychologists discover babies recognize real-life objects from pictures as early as nin... - 0 views

  • Babies begin to learn about the connection between pictures and real objects by the time they are nine-months-old
  • The research found that babies can learn about a toy from a photograph of it well before their first birthday
  • "The study should interest any parent or caregiver who has ever read a picture book with an infant,"
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  • Dr Jeanne Shinskey, from the Department of Psychology at Royal Holloway.
  • these findings suggest that,
  • babies are capable of learning about the real world indirectly from picture books,
  • well before their first birthdays and their first words
  • at least those that have very realistic images like photographs."
  • Researchers familiarized 30 eight and nine-month-olds with a life-sized photo of a toy for about a minute
  • The babies were then placed before the toy in the picture and a different toy and researchers watched to see which one the babies reached for first.
  • In one condition, the researchers tested infants' simple object recognition for the target toy by keeping both objects visible
  • drawing infants' attention to the toys and then placing the toys inside clear containers
  • In another condition, they tested infants' ability to create a continued mental idea of the target toy by hiding both toys from view
  • drawing infants' attention to the toys and then placing the toys inside opaque containers
  • When the toys were visible in clear containers, babies reached for the one that had not been in the picture
  • suggesting that they recognized the pictured toy and found it less interesting than the new toy because its novelty had worn off
  • when the toys were hidden in opaque containers, babies showed the opposite preference
  • they reached more often for the one that had been in the photo, suggesting that they had formed a continued mental idea of it.
  • demonstrates that experience with a picture of something can strengthen babies' ideas of an object so they can maintain it after the object disappears
Mars Base

Numbers Games Devised to Aid People with "Dyscalculia": Scientific American - 0 views

  • Three months on, Christopher seems to be faring better at the number-line game, going so quickly that Babtie asks him to slow down and explain his reasoning for each move
  • dyscalculic children tend to learn much more quickly when they talk through what they do
  • also believes that Christopher's maths anxiety, a near-universal trait of child and adult dyscalculics, is fading
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  • Tetris-like game called Numberbonds, in which bars of different lengths fall down the screen
  • select a block of the correct size to fill out a row
  • emphasizes spatial relationships, which some dyscalculics also struggle with.
  • The Number Sense games, including a snazzy-looking iPhone version of Numberbonds, are intended to nurture the abilities that
  • contends, are the root of numerical cognition and the core deficit of dyscalculia — manipulating precise quantities.
  • In a game called Dots to Track, for example, children must ascribe an Arabic numeral to a pattern of dots, similar to those on dice.
  • When they enter the wrong value — and they often do — the game asks the children to add or remove dots to achieve the correct answer.
  • Other students are improving more slowly, but it is not easy to say why
  • Dyslexia, attention deficit hyperactivity disorder and autism spectrum disorder are common among dyscalculics, and it can be difficult to untangle these problems,
  • with the right practice and attention from teachers and parents, dyscalculic children can thrive,
  • computer games are a supplement, not a replacement, for one-on-one tutoring.
  • in 2009 that Number Race, a game his group developed, modestly improved the ability of 15 dyscalculic kindergarten children to discern the larger of two numbers, but that it had no effect on their arithmetic or counting
  • a Swiss team reported in 2011 that a game that involves placing a spaceship on a number line helped eight- to ten-year-old dyscalculics with arithmetic
  • studied the children in an fMRI scanner during a task that involved arranging numbers.
  • one month after training, the children showed increased activation in the intraparietal sulcus and reduced neural activation elsewhere in the parietal lobes — a hint that their improvements in arithmetic were related to changes involving brain areas that respond to number.
  • hopes to monitor the brains of students such as Christopher as they practice Number Sense, to see if their parietal lobes are indeed changing
  • turned down by every funding source he has applied to
  • dyscalculia, like other learning disabilities, takes a toll on productivity
  • it doesn't attract much attention or money
  • In the United States, for example, the National Institutes of Health spent $2 million studying dyscalculia between 2000 and 2011, compared with more than $107 million on dyslexia.
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Numbers Games Devised to Aid People with "Dyscalculia": Scientific American - 0 views

  • A cognitive scientist who studies numerical cognition and a learning disability likened to dyslexia for mathematics works on identifying its cause as well as ways to help those who suffer from it
  • After conducting some tests,
  • concluded that
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  • “a disaster at arithmetic” and diagnosed him with dyscalculia, a little-known learning disability sometimes called number blindness and likened to dyslexia for maths
  • Researchers estimate that as much as 7% of the population has dyscalculia, which is marked by severe difficulties in dealing with numbers despite otherwise normal
  • well above normal) intelligence
  • he has crusaded to get dyscalculia recognized — by parents, teachers, politicians and anyone who will listen.
  • Number Sense, a suite of educational computer games
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A new way to lose weight? Study shows that changes to gut microbiota may play role in w... - 0 views

  • by colonizing mice with the altered microbial community, the mice were able to maintain a lower body fat, and lose weight – about 20% as much as they would if they underwent surgery
  • New research
  • has found that the gut microbes of mice undergo drastic changes following gastric bypass surgery
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  • In some ways we were biasing the results against weight loss
  • the mice used in the study hadn't been given a high-fat, high-sugar diet to increase their weight beforehand
  • The question is whether we might have seen a stronger effect if they were on a different diet
  • finding ways to manipulate microbial populations to mimic those effects could become a valuable new tool to address obesity
  • study suggests that the specific effects of gastric bypass on the microbiota contribute to its ability to cause weight loss
  • need to learn a good deal more about the mechanisms by which a microbial population changed by gastric bypass exert its effects,
  • then we need to learn if we can produce these effects – either the microbial changes or the associated metabolic changes – without surgery
  • it may be years before they could be replicated in humans, and that such microbial changes shouldn't be viewed as a way to lose
  • pounds without going to the gym
  • the technique may one day offer hope to dangerously obese people who want to lose weight without going through the trauma of surgery.
  • may not be that we will have a magic pill that will work for everyone who's slightly overweight
  • But if we can, at a minimum, provide some alternative to gastric bypass surgery that produces similar effects, it would be a major advance
  • While there had been hints that the microbes in the gut might change after bypass surgery, the speed and extent of the change came as a surprise to the research team
  • In earlier experiments, researchers had shown that the guts of both lean and obese mice are populated by varying amounts of two types of bacteria
  • When mice undergo gastric bypass surgery, however, it "resets the whole picture
  • those changes occurred within a week of the surgery, and weren't short-lived – the altered gut microbial community remained stable for months afterward
  • the results may hold out the hope for weight loss without surgery
  • future studies are needed to understand exactly what is behind the weight loss seen in mice
  • A major gap in our knowledge is the underlying mechanism linking microbes to weight loss
  • certain microbes
  • found at higher abundance after surgery,
  • think those are good targets for beginning to understand what's taking place
  • the answer may not be the specific types of microbes, but a by-product they excrete.
  • In addition to changes in the microbes found in the gut, researchers found changes in the concentration of certain short-chain fatty acids
  • Other studies
  • have suggested that those molecules may be critical in signaling to the host to speed up metabolism, or not to store excess calories as fat.
  • hope to continue to explore those questions
  • such studies will allow us to understand how host/microbial interactions in general can influence the outcome of a given diet
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Twinkle, twinkle little star: New app measures sky brightness - 0 views

  • Researchers from the German "Loss of the Night" project have developed an app for Android smart phones, which counts the number of visible stars in the sky
  • The data from the app will be used by scientists to understand light pollution on a world wide scale.
  • The smartphone app will evaluate sky brightness, also known as skyglow, on a worldwide scale
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  • This data can be used to map the distribution and changes in sky brightness, and will eventually allow scientists to investigate correlations with health, biodiversity, energy waste and other factors
  • The app works by interactively asking users to say whether individual stars are visible. By determining what the faintest visible star is, the researchers learn how many stars are visible at that location, and by extension how bright the sky is
  • With this app, people from around the world can collect data on skyglow without needing expensive equipment
  • some of the testers found that without intending too they learned the names of several stars and constellations
  • is based on the widely used Google Sky Map application
  • development of the app was sponsored by the German Federal Ministry of Research and Education,
  • satellites that observe Earth at night measure the light that is radiating into the sky, not the brightness that is experienced by people and other organisms on the ground
Mars Base

Working alone won't get you good grades, study finds - 0 views

  • Students who work together and interact online are more likely to be successful in their college classes, according to a study
  • 80,000 interactions between 290 students in a collaborative learning environment for college courses
  • major finding was that a higher number of online interactions was usually an indicator of a higher score in the class
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  • High achievers also were more likely to form strong connections with other students and to exchange information in more complex ways
  • tended to form cliques, shutting out low-performing students from their interactions
  • Students who found themselves shut out were not only more likely to have lower grades; they were also more likely to drop out of the class entirely.
  • Elite groups of highly connected individuals formed in the first days of the course
  • "For the first time, we showed that there is a very strong correspondence between social interaction and exchange of information - a 72 percent correlation
  • almost equally interesting is the fact that these high-performing students form 'rich-clubs', which shield themselves from low-performing students, despite the significant efforts by these lower-ranking students to join them.
  • weaker students try hard to engage with the elite group intensively, but can't. This ends up having a marked correlation with their dropout rates
  • might better identify patterns in the classroom that can trigger early dropout alarms
  • allowing more time for educators to help the student and, ideally, reduce those rates through appropriate social network interventions.
  • work is part of
  • wider research effort at the intersection of the computer and social sciences
  • enhance our understanding of the ways in which people share information and how this impacts areas of national significance, such as the spread of health-related or political behavior.
Mars Base

Early sign of Alzheimer's reversed in lab - 0 views

  • One of the earliest known impairments caused by Alzheimer's disease - loss of sense of smell – can be restored by removing a plaque-forming protein in a mouse model of the disease
  • study confirms that the protein, called amyloid beta, causes the loss
  • we can use the sense of smell to determine if someone may get Alzheimer's disease, and use changes in sense of smell to begin treatments, instead of waiting until someone has issues learning and remembering
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  • We can also use smell to see if therapies are working
  • Smell loss can be caused by a number of ailments
  • since the 1970s, it has been identified as an early sign of this disease
  • There is currently no effective treatment or cure for the disease
  • They found that just a tiny amount of amyloid beta – too little to be seen on today's brain scans - causes smell loss in mouse models
  • Amyloid beta plaque accumulated first in parts of the brain associated with smell, well before accumulating in areas associated with cognition and coordination
  • Despite spending more time sniffing, the mice failed to remember smells and became incapable of telling the difference between odors
  • While losses in the olfactory system occurred, the rest of the mouse model brain, including the hippocampus, which is a center for memory, continued to act normally early in the disease stage
  • Mice were given a synthetic liver x-receptor agonist, a drug that clears amyloid beta from the brain
  • After two weeks on the drug, the mice could process smells normally
  • After withdrawal of the drug for one week, impairments returned
  • team are now following-up on these discoveries to determine how amyloid spreads throughout the brain, to learn methods to slow disease progression
Mars Base

NASA - NASA Rover Finds Old Streambed on Martian Surface - 0 views

  • this evidence -- images of rocks containing ancient streambed gravels -- is the first of its kind
  • sizes and shapes of stones offer clues to the speed and distance of a long-ago stream's flow
  • can interpret the water was moving about 3 feet per second, with a depth somewhere between ankle and hip deep
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  • This is the first time we're actually seeing water-transported gravel on Mars
  • transition from speculation about the size of streambed material to direct observation of
  • finding site lies between the north rim of Gale Crater and the base of Mount Sharp, a mountain inside the crat
  • Earlier imaging of the region from Mars orbit allows for additional interpretation of the gravel-bearing conglomerate
  • rounded shape of some stones in the conglomerate indicates long-distance transport from above the rim
  • channel named Peace Vallis feeds into the alluvial fan.
  • abundance of channels in the fan between the rim and conglomerate suggests flows continued or repeated over a long time, not just once or for a few years.
  • discovery comes from examining two outcrops, called "Hottah" and "Link," with the telephoto capability of Curiosity's mast camera during the first 40 days after landing
  • observations followed up on earlier hints from another outcrop, which was exposed by thruster exhaust as Curiosity, the Mars Science Laboratory Project's rover, touched down
  • Hottah looks like someone jack-hammered up a slab of city sidewalk, but it's really a tilted block of an ancient streambed
  • gravels in conglomerates at both outcrops range in size from a grain of sand to a golf ball. Some are angular, but many are rounded
  • shapes tell you they were transported and the sizes tell you they couldn't be transported by wind
  • team may use Curiosity to learn the elemental composition of the material, which holds the conglomerate together, revealing more characteristics of the wet environment that formed these deposits
  • stones in the conglomerate provide a sampling from above the crater rim, so the team may also examine several of them to learn about broader regional geology.
  • slope of Mount Sharp in Gale Crater remains the rover's main destination
  • sulfate minerals detected there from orbit can be good preservers of carbon-based organic chemicals that are potential ingredients for life
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