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Mars Base

Scientists can now block heroin, morphine addiction; clinical trials possible within 18... - 0 views

medicalxpress.com/...heroin-morphine-addiction.html

GrabBag DrugTech

shared by Mars Base on 16 Aug 12 - No Cached
  • Scientists can now block heroin, morphine addiction; clinical trials possible within 18 months
  • an international team of scientists has proven that addiction to morphine and heroin can be blocked, while at the same time increasing pain relief.
  • University of Adelaide and University of Colorado has discovered the key mechanism in the body's immune system that amplifies addiction to opioid drugs
  • ...2 more annotations...
  • the drug (+)-naloxone (pronounced: PLUS nal-OX-own) will selectively block the immune-addiction response
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Mars Base

'The Pill' for Men Is Closer to Reality - ScienceNOW - 0 views

news.sciencemag.org/...d-points-toward-the-pill-.html

scibyte59 DrugTech

shared by Mars Base on 17 Aug 12 - No Cached
  • A compound called JQ1, which was originally developed as a cancer therapy, can also cause reversible infertility in male mice without apparent side effects for the rodents or their offspring
  • male contraceptive that would be more effective than condoms and more easily reversible than a vasectomy
  • compound isn’t ready for testing in healthy men
  • ...11 more annotations...
  • offers a promising lead
  • originally developed as an anticancer agent
  • designed to inhibit a protein called BRD4, which helps regulate cell division and is known to be involved in a type of aggressive skin cancer
  • after 6 weeks of daily injections of JQ1 the animals' sperm counts were reduced by nearly 90%. Only 5% of the remaining sperm were able to swim properly, compared with 85% of sperm in control mice. After 3 months of treatment, none of the mice were able to sire offspring
  • had no apparent effect on the production of testosterone or other hormones made by the testes
  • A month or two after treatment stopped, all of the mice were again able to father as many pups as control mice
  • no obvious side effects in the mice, and the offspring of the treated animals showed no abnormalities.
  • compound seems to target developing sperm both before and after meiosis
  • If you're taking healthy people in their twenties and giving them a drug, you want to be very sure it doesn’t affect anything else
  • the lifespans of mice aren’t sufficient to test the possible long-term effects of drugs that people might want to be able to take for decades
  • Primate experiments, meanwhile, are prohibitively expensive, and funding is scarce
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