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Egg In Tiny Doses Curbs Allergy - Science News - 0 views

  • Exposure to increasing amounts of egg every day over two years can seemingly rid some children of an egg allergy
  • gradual introduction into the diet appears to re-train the immune system
  • Many other children in the study developed an ability to cope with small amounts of egg without a serious reaction — but only while being treated
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  • interest in providing protection from an accidental reaction” than in having the child gain a new food group
  • 55 children ages 5 to 11 with egg allergies, confirmed by skin-prick tests, medical history and the presence of antibodies to egg protein
  • All of them got an unmarked powder added to their food daily
  • Forty kids were randomly assigned to receive the egg treatment and 15 got cornstarch as a control
  • treatment amounted to a few grains of powdered egg white on the first day and gradually grew to the equivalent of one-third of an egg
  • After 22 months, 30 of the 40 children getting the treatment were able to consume 10 grams of powdered egg white without having a visible reaction
  • Five of the 40 did have a reaction to the egg test, as did all children in the placebo group
  • Another five children who had allergic reactions to the initial treatment dropped out of the study early on
  • Four to six weeks after stopping treatment, the children who didn’t react to the egg test got tested again
  • with 10 grams of egg white powder plus a cooked egg
  • Eleven passed that test. A year later, 10 of them were eating eggs at will
  • remaining challenges will be to identify beforehand which children are the most likely to benefit from the treatment
  • predictions may emerge from tests of their immune cells and proteins
  • blood tests of kids whose treatment succeeded showed an accumulation of positive immune changes during treatment
  • reaction. Whether those changes are permanent is unknown
  • about 10 percent of children given this type of oral treatment for egg, peanut or milk allergies — including roughly that fraction in this study — have reactions early and drop out, Burks says. “For a small group of kids, this isn’t the right therapy
  • Don’t try this at home. The Food and Drug Administration would need to approve an oral treatment for clinical use.
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