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Vera Gorbunova and Andrei Seluanov of the University of Rochester have found that human cells undergoing oxidative stress caused by environmental chemicals or routine cellular processes produce a protein (SIRT6) that stimulates cells to repair DNA double-strand breaks, thought to be associated with premature aging and cancer. The team first measured levels of SIRT6 in stressed cells, then treated a second group of stressed cells with a drug that deactivates the protein. DNA repair in the second group stopped, confirming SIRT6′s role.  The team also found that SIRT6 acts in concert with another protein, called PARP1, to make the repairs. Furthermore, the team found that increased levels of SIRT6 lead to faster DNA repair. They suspect that the protein acts as a "master regulator," coordinating stress and DNA repair activities. Ref.: Zhiyong Mao, Christopher Hine, Xiao Tian, Michael Van Meter, Matthew Au, Amita Vaidya, Andrei Seluanov, and Vera Gorbunova. SIRT6 Promotes DNA Repair Under Stress by Activating PARP1. Science 17 June 2011: 1443-1446. [DOI:10.1126/science.1202723]

ScienceDaily (June 4, 2011) - Do the principles of quantum mechanics apply to biological systems? Until now, says Prof. Ron Naaman of the Institute's Chemical Physics Department (Faculty of Chemistry), both biologists and physicists have considered quantum systems and biological molecules to be like apples and oranges. But research he conducted together with scientists in Germany, which appeared recently in Science, shows that a biological molecule -- DNA -- can discern between quantum states known as spin.

Harvard researchers have created nanodevices made of DNA that self-assemble and can be programmed to move and change shape on demand. The nanodevice structure is based on the principle of tensegrity: its strength and stability results from the way it distributes and balances the counteracting forces of tension and compression. This new technology could lead to nanoscale medical devices and drug delivery systems, such as virus mimics that introduce drugs directly into diseased cells. Or it could one day be used to reprogram human stem cells to regenerate different kinds of injured organs and tissue.

Researchers from Purdue University and colleagues are developing new technologies that combine a laser and electric fields to manipulate fluids and tiny particles such as bacteria, viruses, and DNA molecules for a wide range of potential applications, including medical diagnostics, testing food and water, crime-scene forensics, and pharmaceutical manufacturing.. This "hybrid optoelectric manipulation in microfluidics" technology could allow for innovative sensors and analytical devices for "lab-on-a-chip" applications, or miniature instruments that perform measurements normally requiring large laboratory equipment, the researchers said. The technology works by first using a red laser to position a droplet on a platform specially fabricated at Purdue. Next, a highly focused infrared laser is used to heat the droplets, and then electric fields cause the heated liquid to circulate in a "microfluidic vortex." This vortex is used to isolate specific types of particles in the circulating liquid, like a micro centrifuge. Particle concentrations replicate the size, location and shape of the infrared laser pattern. The technology can also be used in nanomanufacturing because it shows promise for the assembly of suspended particles (colloids), the researchers said. Ref.: Steven T. Wereley, et al., Hybrid opto-electric manipulation in microfluidics-opportunities and challenges, Lab on a Chip, 2011; 11 (13): 2135 [DOI: 10.1039/C1LC20208A]

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