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chanon chiarnpattanodom

Chimeric green fluorescent protein-aequorin as bioluminescent Ca2+ reporters at the sin... - 1 views

www.pnas.org/...7260.full

shared by chanon chiarnpattanodom on 16 Apr 12 - No Cached
    • chanon chiarnpattanodom
      chanon chiarnpattanodom on 16 Apr 12
       
      Experiment on Ca2+ reaction with a protein aequorin. Aequorin can be found in jellyfish, when in contact with Ca2+ will emit light. Using the gene that contributes to this protein, make a similar protein emitting another wavelength of light.
orasa sukmark

Shot of Young Stem Cells Makes Rapidly Aging Mice Live Much Longer and Healthier - Gate... - 1 views

www.gate2biotech.com/-2130

shot stem cells aging much mice longer gate biotech com DNA genetics disease gene RNA brain human epigenetics research Genes

shared by orasa sukmark on 16 Apr 12 - No Cached
  • animals that got the stem/progenitor cells improved their health and lived two to three times longer than expected,
  • "Our experiments showed that mice that have progeria, a disorder of premature aging, were healthier and lived longer after an injection of stem cells from young, healthy animals," Dr. Niedernhofer said. "That tells us that stem cell dysfunction is a cause of the changes we see with aging."
  • "Typically the progeria mice die at around 21 to 28 days of age, but the treated animals lived far longer -- some even lived beyond 66 days. They also were in better general health."
  • ...2 more annotations...
  • we injected stem/progenitor cells from young, healthy mice into the abdomens of 17-day-old progeria mice,
  • As the progeria mice age, they lose muscle mass in their hind limbs, hunch over, tremble, and move slowly and awkwardly. Affected mice that got a shot of stem cells just before showing the first signs of aging were more like normal mice, and they grew almost as large.
  • orasa sukmark on 16 Apr 12
     
    the experiment from the University of Pittsburgh shows that the mice can be stronger live longer after they were injected with stem cells from young healthy animals.
Nickyz P.

We Need More Research On Genetically Altered Salmon Says FDA Advisory Panel - 1 views

www.medicalnewstoday.com/...201862.php

shared by Nickyz P. on 16 Apr 12 - No Cached
  • A panel of experts that advises the US Food and Drug Administration (FDA) decided on Monday more research was needed before it could vote on whether to recommend approval to allow genetically modified salmon to be bred for human consumption in the US.
  • To make the genetically modified Atlantic salmon, they take the growth gene from the Pacific chinook salmon and insert it into the DNA of newly fertilized Atlantic salmon eggs. However, this of itself is not enough to keep the salmon growing all year round: to keep the growth gene permanently "switched on", the AquaBounty scientists also add a small piece of DNA from another fish called the ocean pout.
Sasicha Manupipatpong

Memory in adults impacted by versions of four genes - 2 views

www.sciencedaily.com/...120415151347.htm

genes alzheimer's hippocampus shrinking

shared by Sasicha Manupipatpong on 16 Apr 12 - No Cached
  • advanced understanding of the genetic components of Alzheimer's disease and of brain development.
  • understanding of the genetic components of Alzheimer's disease and of brain development
  • certain versions of four genes may speed shrinkage of a brain region involved in making new memories
  • ...12 more annotations...
  • hippocampus, normally shrinks with age, but if the process speeds up, it could increase vulnerability to Alzheimer's disease
  • two genes associated with intracranial volume -- the space within the skull occupied by the brain when the brain is fully developed in a person's lifespan
  • gene variants identified in the first study do not cause Alzheimer's, but they may rob the hippocampus of a kind of "reserve" against the disease
  • cause cell destruction and dramatic shrinkage of this key brain site
  • almost twice the Alzheimer's risk if he or she had these versions of the gene
  • if a person with one of these variants did get Alzheimer's, the disease would attack an already compromised hippocampus and so would lead to a more severe condition at a younger age than otherwise
  • Alzheimer's disease causes much of its damage by shrinking hippocampus volume
  • loses a greater-than-average amount of volume due to the gene variants we've identified, the hippocampus is more vulnerable to Alzheimer's
  • associations impacting intracranial volume, which is an indirect measure of the size of the brain at full development.
  • brain volume and intracranial volume are both highly heritable
  • no associations for brain volume
  • one of these genes has played a unique evolutionary role in human development, and perhaps we as a species are selecting this gene as a way of providing further advances in brain development
  • Sasicha Manupipatpong on 16 Apr 12
     
    The shrinking of the hippocampus, which occurs with age in normal people, was found to be accelerated by certain versions of four genes, which could increase susceptibility to Alzheimer's disease, which also affects the volume of the hippocampus.
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