Now referred to as long-term potentiation (LTP), this mechanism has since become the most intensively studied in modern neuroscience,and is widely believed to be the cellular basis of learning and memory, although this is yet to be proven unequivocally.
Institute of Psychiatry (IoP) - - 0 views
Depression and Creativity Symposium Webcast (Library of Congress) - 0 views
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TITLE: "Depression and Creativity" Symposium SPEAKER: Kay Redfield Jamison, Terence Ketter, Peter Whybrow EVENT DATE: 02/03/2009 RUNNING TIME: 124 minutes DESCRIPTION: Kay Redfield Jamison, professor of psychiatry and behavioral sciences and co-director of the Johns Hopkins Mood Disorders Center at the Johns Hopkins University School of Medicine, convened a discussion of the effects of depression on creativity. Joining Jamison were two distinguished colleagues from the fields of neurology and neuropsychiatry, Dr. Terence Ketter and Dr. Peter Whybrow. The Music and the Brain series is co-sponsored by the Library's Music Division and Science, Technology and Business Division, in cooperation with the Dana Foundation. The "Depression and Creativity" symposium marks the bicentennial of the birth of German composer Felix Mendelssohn (1809-1847), who died after a severe depression following the death of his sister, Fanny Mendelssohn Hensel, also a gifted composer. Speaker Biography: One of the nation's most influential writers on creativity and the mind, Kay Redfield Jamison is a noted authority on bipolar disorder. She is the co-author of the standard medical text on manic-depressive illness and author of "Touched with Fire," "An Unquiet Mind," "Night Falls Fast" and "Exuberance: The Vital Emotion." Speaker Biography: Dr. Terence Ketter is known for extensive clinical work with exceptionally creative individuals and a strong interest in the relationship of creativity and madness. He is professor of psychiatry and behavioral sciences and chief of the Bipolar Disorders Clinic at Stanford University School of Medicine. Speaker Biography: Dr. Peter Whybrow, an authority on depression and manic-depressive disease, is director of the Semel Institute for Neuroscience and Human Behavior at the University of California, Los Angeles (UCLA). He is also the Judson Braun Distinguished Professor and executive chair of the Department of Psychiatry and Biobehavioral Sciences at th
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Neurophilosophy : Experience induces global reorganization of brain circuitry - 0 views
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In the new study, Santiago Canals of the Max Planck Institute for Biological Cybernetics in Tübingen and his colleagues used the same protocol to induce LTP. But while the vast majority of researchers have investigated LTP in slices of hippocampal tissue, this study involved observing LTP in live animals.
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This new research provides the first evidence that the local modifications in synaptic connections induced by LTP lead to long-lasting changes in the activity of a diffuse network of brain regions, and even to facilitated communication between the two hemispheres. The fMRI data showed that hippocampal LTP recruits higher order association areas, as well as regions involved in emotions and others subserving different sensory modalities, all of which are known to be involved in memory formation.
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Experience induces global reorganization of brain circuitry. This new research provides the first evidence that the local modifications in synaptic connections induced by LTP lead to long-lasting changes in the activity of a diffuse network of brain regions, and even to facilitated communication between the two hemispheres.
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