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Skin is largest organ of body. It provides safety from external harmful things. Skin has also relation with defense system. Immune system and nervous system have also close relationship. Any skin disease may be leading you to get involve in many other associated disease. It is very important and necessary to understand the function of skin. Discussion of skin function is too long and not coverable in one or two articles.Infact numbers of books are required for this purpose, here we will talk about skin function in general and one of skin disease named as vitiligo.