or more than a decade scientists have been saying that a genomic revolution will transform medicine, making it possible to scan all of a person's DNA to predict risk and customize medical care.
Well, we've got the machines. Where's the revolution?
Getting closer, say researchers at Stanford University, who tested the technology on 12 people. But not quite ready for every doctor's office.
Genomics England, with the consent of participants and the support of the public, is creating a lasting legacy for patients, the NHS and the UK economy through the sequencing of 100,000 genomes: the 100,000 Genomes Project.
Pharmacogenomics can play an important role in identifying responders and non-responders to medications, avoiding adverse events, and optimizing drug dose. Drug labeling may contain information on genomic biomarkers and can describe:
Drug exposure and clinical response variability
Risk for adverse events
Genotype-specific dosing
Mechanisms of drug action
Polymorphic drug target and disposition genes
The table below lists FDA-approved drugs with pharmacogenomic information in their labeling. The labeling for some, but not all, of the products includes specific actions to be taken based on the biomarker information. Pharmacogenomic information can appear in different sections of the labeling depending on the actions. For more information, please refer to the appropriate labeling guidance.
Genetic and biotechnology can improve food security, the environment and public health. Yet dramatic innovation can lead to unintended consequences and present ethical challenges. In theory, the study of genetics and related cutting edge sciences are widely celebrated. But in practice, the words "gene" and "genetic engineering" often stir fear and misunderstanding when applied to biomedicine and farming. Intricate science scares people who don't understand risk and complexity. What is the potential of agricultural and human genetics? The commitment of the GLP is to promote public awareness of genetics and science literacy.
The video explains how Clinical Pharmacology can help to deliver the right dose for every patient by combining clinical trials data and modeling & simulation approaches during drug development.