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Lying dormant in our genomes are millions of jumping genes. Originally discovered by Barbara McClintock, transposons are DNA sequences that can move from one location to another in our DNA. transposons cause mutations when they jump to new locations, so keeping them from jumping is important. 

The article "The difference makers" (10.9 readability score) gives an overview of transposons, or "jumping genes," and how these bits of genetic material have affected genetic variety and evolution in humans and other organisms. Students can focus on details reported in the article, follow connections to earlier articles about transposons and human evolution, explore crosscurricular connections to other major science topics, and construct a phylogenetic tree of primate evolution based on the locations of retroviral sequence insertions in chromosome 21

The mouse is the leading organism for disease research. A rich resource of genetic variation occurs naturally in inbred and special strains owing to spontaneous mutations. However, one can also obtain desired gene mutations by using the following processes: targeted mutations that eliminate function in the whole organism or in a specific tissue; forward genetic screens using chemicals or transposons; or the introduction of exogenous transgenes as DNAs, bacterial artificial chromosomes (BACs) or reporter constructs. The mouse is the only mammal that provides such a rich resource of genetic diversity coupled with the potential for extensive genome manipulation, and is therefore a powerful application for modeling human disease.

If thinking about the billions of bacteria taking up residence in and on your body gives you the willies, you probably won't find it comforting that humans are also full of viruses. These maligned microbes are actually intertwined in the very fibers of our being-about 8 percent of our genetic material is made up of absorbed forms of retroviruses, the viral family to which HIV, the pathogen that causes AIDS, belongs.