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In 1932, the Public Health Service, working with the Tuskegee Institute, began a study to record the natural history of syphilis in hopes of justifying treatment programs for blacks. It was called the "Tuskegee Study of Untreated Syphilis in the Negro Male."

The Tuskegee Syphilis Study was initiated because known treatments for syphilis, in 1932, had shown little demonstrated effect, in addition to being toxic and dangerous. The dependent variable in the Tuskegee Experiment (the knowledge researchers wanted), was whether persons with syphilis were, in fact, better off without the treatment.

Known officially as the Tuskegee Study of Untreated Syphilis in the Negro Male, the 40-year experiment run by Public Health Service officials followed 600 rural black men in Alabama with syphilis over the course of their lives, refusing to tell patients their diagnosis, refusing to treat them for the debilitating disease, and actively denying some of them treatment.

Center website, presidential apology

Session description: The session will provide an introduction to the ethics of research involving human participants. It will ad-dress the history of research ethics, present a contemporary eth-ical framework, and discuss its application to differing kinds of research studies. The ethical framework consists of four principles: respect for persons, beneficence, justice, and respect for communities. Each principle provides the foundation for ethical rules, including requirements for informed consent and confidentiality of health information. Taken together these ethical principles and rules provide a comprehensive framework for the analysis of ethical challenges in health research.