LONDON, England- (24 July 1997)- Move over Dolly, and make room for Polly, the first sheep cloned by nuclear transfer technology bearing a human gene. Investors hope the lamb will make them a mint, but more importantly, the arrival of Polly could be good news for hemophiliacs and others who rely on expensive protein therapy of their diseases.
A team of Indian biologists has demonstrated that a key component of the water buffalo genome can be manipulated to produce foreign proteins in the buffalo's milk (J. Biotechnol. 2015, DOI:10.1016/j.jbiotec.2015.02.001). The findings suggest the possibility of modifying the genetic material of water buffalo-that is, creating transgenic buffalo-to produce protein drugs, says team member Subeer S. Majumdar, of the National Institute of Immunology, in New Delhi.