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The Great Diseases curriculum is targeted to elective biology (Biology II). It is divided into four different modules. Each module consists of a 6-week course that is focused on a specific class of disease. Within each module, there are five units, each corresponding to a week's worth of lessons. Within each unit there are therefore approximately five forty-five minute lessons. Each module has been designed so it is thoroughly aligned with the Next Generation Science Standards.

Similar to humans who have obsessive compulsive disorder, dogs exhibit compulsive behaviors, in which they might repetitively spin around, chase their tail, bark, chew, or suck on a toy or a part of their body for an excessive amount of time. In the latest study from Tufts University, researchers identified genetic pathways that increase the severity of canine compulsive disorders in Doberman pinschers. This discovery may lead to the development of improved treatments and therapies for obsessive compulsive disorder (OCD) in people.