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Most 12-year-olds love playing videogames -- Thomas Suarez taught himself how to create them. After developing iPhone apps like "Bustin Jeiber," a whack-a-mole game, he is now using his skills to help other kids become developers. (Filmed at TEDxManhattanBeach.)

A powerful tool called pVAAST that combines linkage analysis with case control association has been developed to help researchers and clinicians identify disease-causing mutations in families faster and more precisely than ever before. The researchers describe cases in which pVAAST (the pedigree Variant Annotation, Analysis and Search Tool) identified mutations in two families with separate diseases and a de novo or new variation in a 12-year-old who was the only one in his family to suffer from a mysterious and life threatening intestinal problem.