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In a few short years innovation has moved from being the domain of wild-haired creatives into an effective business process that acts as one of the levers for extracting value [1]. At this point it is timely to pause and consider 'what's next?' After all, the global environment continues to get more complex, competition gets tougher and the demands of customers increasingly sophisticated. How can countries, regions, cities, private and public sector organizations respond to this challenge? How can they succeed in a marketplace where innovation is an established technique, widely deployed? How do we reach way beyond what is possible and proceed as though it could be? In short: in order to maintain competitive advantage, what comes after innovation?