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Hadoop comes bundled with launch scripts to simplify initializing an Amazon Elastic Compute Cloud (EC2) cloud for Hadoop. Once initialized, running CloudBurst is identical to running on a local cluster. If you use EC2 regularly with the same datasets (i.e. the human genome as a reference), you will probably want to copy the data once to Amazon Simple Storage Service (S3) so you can quickly copy the data from S3 to your cloud at low cost.

With the following three steps, you can set up a Disco cluster in the Amazon's Elastic Computing Cloud. This will cost you a few dollars (or more, depending on your needs) but requires no resources on your side besides a single machine that you use to setup the cluster. In this setup Disco master and nodes run on EC2. Your Disco client can run either on the master node on EC2 or on a local machine.