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NOIs Due: December 4, 2017; Proposals Due: February 2, 2018. Research Opportunities in Space Biology (ROSBio) - 2016 "Appendix G: Solicitation of Proposals for Flight and Ground Space Biology Research" NNH16ZTT001N-FGThis Appendix to the Research Opportunities in Space Biology (ROSBio) - 2016 NASA Omnibus Research Announcement (hereafter referred to as ROSBio-2016 Omnibus NRA) solicits proposals that will increase NASA's understanding of how living systems acclimate to spaceflight to support human space exploration.The solicited research will fall into into the following four research emphases:1. Microbiomes of the Built Environment (MoBE) of Spacecraft; 2. Plant Biology to support Human Space Exploration; 3. Animal Biology in support of Human Space Exploration; 4. Molecular and Cellular Biology.

This Appendix to the Research Opportunities in Space Biology (ROSBio) - 2016 NASA Omnibus Research Announcement (hereafter referred to as ROSBio-2016 Omnibus NRA) solicits proposals that will increase NASA's understanding of how living systems acclimate to spaceflight to support human space exploration. The solicited research will fall into the following four research emphases: 1. Microbiomes of the Built Environment (MoBE) of Spacecraft 2. Plant Biology to support Human Space Exploration 3. Animal Biology in support of Human Space Exploration 4. Molecular and Cellular Biology

NASA's Space Life and Physical Sciences Research and Applications Division (SLPSRAD) has been invited to participate in the Orion Exploration Mission 1 (EM-1), which is an unmanned lunar orbital flight tentatively scheduled to occur in 2019. The NASA Space Biology Program has been allocated two experiment payload locations inside the EM-1 Orion capsule for the specific purpose of conducting scientific investigations. NASA is soliciting proposals for biological studies that contribute answers to NASA's Strategic Objectives 1.2: Understand Responses of Physical and Biological Systems to Spaceflight, and 2.2: Conduct Exploration in Deep Space, (https://www.nasa.gov/sites/default/files/atoms/files/nasa_2018_strategic_plan.pdf), the National Academy of Science (NAS) Decadal report (http://www.nap.edu/catalog/13048.html) recommendations for exploration, and Space Biology research priorities (https://www.nasa.gov/sites/default/files/atoms/files/16-05-11_sb_plan_2.pdf ).

"Solicitation of Proposals to Conduct Research Using Microgravity Simulation Devices" NASA Research Announcement (NRA) Appendix D - NNH16ZTT001N-MS NRA This National Aeronautics and Space Administration Research Announcement: "Solicitation of Proposals to Conduct Research Using Microgravity Simulation Devices" is an Appendix to the NASA Omnibus Research Announcement ROSBio-2016 (NNH16ZTT001N NRA). This Appendix solicits proposals that will use microgravity simulation devices to test specific hypotheses regarding the effects of altered gravity on biological systems, including cells, tissues, microorganisms, plants, and whole organisms. Proposing investigators will have the option of using the Microgravity Simulation Support Laboratory (MSSL) at the Kennedy Space Center, or using microgravity simulation devices at other locations. Proposals must address Space Biology research emphases, visions, and goals identified in the ROSBio-2016 Omnibus NRA or in the Space Biology Science Plan 2016-2025, and/or recommendations from the Decadal Survey.

This National Aeronautics and Space Administration NRA "Solicitation of Proposals for Possible Inclusion in a Russian Bion-M2 Mission" is an Appendix to the NASA Omnibus Research Announcement ROSBio-2016 (NNH16ZTT001N NRA). NASA's Space Life and Physical Sciences Research and Applications Division (SLPSRAD) has been invited to propose candidate experiments from U.S. investigators for possible inclusion in the Bion-M2 mission, which will occur in 2020 or 2021. The NASA Space Biology Program, therefore, requests proposals for flight investigations that fit within the Russian IBMP flight experiment designs as described in Appendix C (NNH16ZTT001N-BION) to the ROSBio-2016 Omnibus NRA. For this Appendix, NASA Space Biology will use a two-phase submission and review process. The first phase will require the submission of a preliminary proposal, hereafter referred to as a pre-proposal. Pre-proposals will be evaluated by NASA and possibly by the IBMP/RAS for their suitability for inclusion in mission planning. Investigators whose pre-proposals are found to satisfy the evaluation criteria described in Appendix C will be invited to submit complete full proposals during phase 2, which will occur at a later date, after more details about the Bion-M2 mission become available.

This NASA Research Announcement (NRA) solicits hypothesis-driven space-flight research in Space Biology (SB) to be conducted on ISS. NASA SB experiments have one or more of the following primary goals: 1) to effectively use microgravity and the other characteristics of the space environment to enhance our understanding of basic biological processes; 2) to develop the scientific and technological foundations for a safe, productive human presence in space for extended periods and in preparation for exploration; and 3) to apply this knowledge and technology to improve our nation's competitiveness, education, and the quality of life on Earth. NASA SB experiments will be designed to discover how space flight affects a diverse group of microorganisms, plants, and animals; study the effects of gravity (g) across the g-spectrum, i.e., from micro- to hyper-gravity; and characterize the biological effects of radiation, magnetic fields, and the interaction among species i n the unusual environments of space and spacecraft. 

Division of Ocean Sciences (OCE) is potentially interested in projects that integrate with the NASA field program intellectually and provide substantive advances in the basic scientific understandings of the "biological pump" or any associated biological, chemical, physical, or geological processes. NSF supported a workshop in February 2016 on the "Biology of the Biological Pump" at which basic research topics that could complement EXPORTS science were identified. OCE will consider additional aspects of the export system as well.

Our Data-Driven Discovery Initiative seeks to advance the people and practices of data-intensive science, to take advantage of the increasing volume, velocity, and variety of scientific data to make new discoveries. Within this initiative, we're supporting data-driven discovery investigators - individuals who exemplify multidisciplinary, data-driven science, coalescing natural sciences with methods from statistics and computer science. These innovators are striking out in new directions and are willing to take risks with the potential of huge payoffs in some aspect of data-intensive science. Successful applicants must make a strong case for developments in the natural sciences (biology, physics, astronomy, etc.) or science enabling methodologies (statistics, machine learning, scalable algorithms, etc.), and applicants that credibly combine the two are especially encouraged. Note that the Science Program does not fund disease targeted research. It is anticipated that the DDD initiative will make about 15 awards at ~$1,500,000 each, at $200K-$300K/year for five years.

The purpose of this FOA is to promote the development of in vitro microphysiological systems in modeling human diseases and conditions that mimic the pathology in major organs and tissues in the human body, when exposed to the extreme environments of space, and the use of these models at the International Space Station-U.S. National Laboratory (ISS-NL) to facilitate the assessment of biomarkers, bioavailability, efficacy, and toxicity of therapeutic agents prior to entry into clinical trials. Funds from the NIH will be made available through the UG3/UH3 cooperative agreement mechanism. During the initial two-year UG3 phase, support will be provided to develop robust models that recapitulate the progression and pathology of human diseases and conditions exposed to prolonged microgravity environment. Following administrative review, the two-year UH3 phase will build upon successful UG3 models to demonstrate the functional utility of the models for more defined experiments at the ISS-NL. It is anticipated that these studies will lead to identification of novel treatment mechanisms through better understanding of disease biology, drug screening, assessment of candidate therapies for efficacy and safety assessments, and establishing the pre-clinical foundation that will inform clinical trial design on Earth.

NASA and the Sloan Foundation have agreed through a Space Act Agreement to work in parallel for a common purpose: to sponsor studies designed to provide insight into the microbiome of the built environment of the ISS that will advance our knowledge and understanding of human-built habitats on Earth, to enhance ISS utilization, and to inform the development of future space exploration vehicles that are occupied by humans. NASA is soliciting, through this Appendix, research applications for Postdoctoral Fellowships from early career scientists to design experiments that utilize a NASA collection of ISS microbial isolates collected over a decade or more to help understand better how microbial communities colonize, adapt, and evolve on the ISS. All proposals must propose experiments that utilize these microbial isolates collected from the ISS that have been archived at the Johnson Space Center.

NASA and the Sloan Foundation have agreed through a Space Act Agreement to work in parallel for a common purpose: to sponsor studies designed to provide insight into the microbiome of the built environment of the ISS that will advance our knowledge and understanding of human-built habitats on Earth, to enhance ISS utilization, and to inform the development of future space exploration vehicles that are occupied by humans. NASA is soliciting, through this Appendix, research applications for Postdoctoral Fellowships from early career scientists to design experiments that utilize a NASA collection of ISS microbial isolates collected over a decade or more to help understand better how microbial communities colonize, adapt, and evolve on the ISS. All proposals must propose experiments that utilize these microbial isolates collected from the ISS that have been archived at the Johnson Space Center. 

This ROSES-2014 NRA (NNH14ZDA001N) solicits basic and applied research in support of NASA's Science Mission Directorate (SMD). This NRA covers all aspects of basic and applied supporting research and technology in space and Earth sciences, including, but not limited to: theory, modeling, and analysis of SMD science data; aircraft, scientific balloon, sounding rocket, International Space Station, CubeSat, and suborbital reusable launch vehicle investigations; development of experiment techniques suitable for future SMD space missions; development of concepts for future SMD space missions; development of advanced technologies relevant to SMD missions; development of techniques for and the laboratory analysis of both extraterrestrial samples returned by spacecraft, as well as terrestrial samples that support or otherwise help verify observations from SMD Earth system science missions; determination of atomic and composition parameters needed to analyze space data, as well as returned samples from the Earth or space; Earth surface observations and field campaigns that support SMD science missions; development of integrated Earth system models; development of systems for applying Earth science research data to societal needs; and development of applied information systems applicable to SMD objectives and data.

This ROSES NRA (NNH17ZDA001N) solicits basic and applied research in support of NASA's Science Mission Directorate (SMD). The NRA covers all aspects of basic and applied supporting research and technology in space and Earth sciences, including, but not limited to: theory, modeling, and analysis of SMD science data; aircraft, scientific balloon, sounding rocket, International Space Station, CubeSat and suborbital reusable launch vehicle investigations; development of experiment techniques suitable for future SMD space missions; development of concepts for future SMD space missions; development of advanced technologies relevant to SMD missions; development of techniques for and the laboratory analysis of both extraterrestrial samples returned by spacecraft, as well as terrestrial samples that support or otherwise help verify observations from SMD Earth system science missions; determination of atomic and composition parameters needed to analyze space data, as well as returned samples from the Earth or space; Earth surface observations and field campaigns that support SMD science missions; development of integrated Earth system models; development of systems for applying Earth science research data to societal needs; and development of applied information systems applicable to SMD objectives and data.