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The purpose of this Funding Opportunity Announcement (FOA) is to fund highly innovative and promising research that tests multi-level physical activity intervention programs acting on at least two levels of the socio-ecological model and designed to increase health-enhancing physical activity: 1) in persons or groups that can benefit from such activity; and 2) that could be made scalable and sustainable for broad use across the nation. This FOA provides support for up to 5 years for research planning, intervention delivery, and follow-up activities.

The DOE SC program in Biological and Environmental Research (BER) hereby announces its interest in receiving applications for research in Environmental Systems Science (ESS), including Terrestrial Ecosystem Science (TES) and Subsurface Biogeochemical Research (SBR). The goal of the Environmental System Science (ESS) activity in BER is to advance a robust, predictive understanding of the set of interdependent physical, biogeochemical, ecological, hydrological, and geomorphological processes for use in Earth system, ecosystem and reactive transport models. Using an iterative approach to model-driven experimentation and observation, and interdisciplinary teams, ESS-supported scientists work to unravel the coupled physical, chemical and biological processes that control the structure and functioning of terrestrial ecosystems and integrated watersheds across critical spatial and temporal scales. This FOA will consider applications that focus on improving the understanding and representation of terrestrial and subsurface environments in ways that advance the sophistication and capabilities of local, regional, and larger scale models.

The Understanding the Rules of Life: Microbiome Theory and Mechanisms (URoL:MTM) program is an integrative collaborationacross Directorates and Offices within the National Science Foundation. The objective of URoL:MTM is to understand and establish the theory and mechanisms that govern the structure and function of microbiomes, a collection of microbes in a specific habitat/environment. This may include but is not limited to host-associated microbiomes, such as those with humans and other organisms, where i) the microbiome impacts host physiology, behavior, development, and fitness; ii) the host influences the metabolic activity, dynamics and evolution of the microbiome, and iii) the environment (biological, chemical, physical, and social) influences and is influenced by both the host and the microbiome. Recent progress has transformed our ability to identify and catalogue the microbes present in a given environment and measure multiple aspects ofbiological, chemical, physical, and social environments that affect the interactions among the members of the microbiome, the host, and/or habitat. Much descriptive and correlative work has been performed on many microbiome systems, particularly those in the human, soil, aquatic, and built environments. This research has resulted in new hypotheses about the microbiome's contributions to potential system function or dysfunction. The current challenge is to integrate the wide range of accumulated data and information and build on them to develop new causal/mechanistic models or theories of interactions and interdependencies across scales and systems.