Group items tagged

Despite the increasing number of complex parenteral dosage forms including polymeric micelles, liposomes, nanosuspensions and others, currently there is still a lack of compendial or biorelevant in vitro drug release assays for these complex dosage forms. The purpose of this study is to evaluate current in vitro release methods for complex parenteral dosage forms and analyze their capability of detecting formulation differences, predicting in-vivo performance, as well as their method robustness. This study is intended to advance the regulatory review process of complex parenteral drug products, which in turn will help provide the US public with access to high quality generic complex parenteral drug products.

The MPM program supports fundamental, hypothesis-driven research on the interrelationship of materials processing, structure, properties, performance and process control. Analytical, experimental, and numerical studies are supported, including novel processing methods for any materials system (metals, polymers, ceramics, hybrids, composites, etc.). Proposed research should include the consideration of cost, performance, and feasibility of scale-up, as appropriate. Research that address multi-scale and/or multi-functional materials systems is encouraged as is research in support of environmentally-benign manufacturing. Collaborative proposals with industry (GOALI) are encouraged. Research on micro-scale (and larger) processes is funded by the MPM program; research on processing at the submicron or nano scale is funded by the Nanomanufacturing (NM) program. Research on solid freeform fabrication processes is funded by the Manufacturing Machines and Equipment (MME) program, as are material removal process proposals such as cutting or grinding. Proposals that focus on research leading to new paradigms of material systems design should consider the Design of Engineering Material Systems (DEMS) program. Proposals that primarily focus on fundamental material composition-structure-property studies, where neither processing nor manufacturing plays a significant role in the proposed work, should be submitted to the Materials and Surface Engineering (MSE) program or to the appropriate program in the DMR division.Investigators wishing to serve on a proposal review panel should email the Program Director with a short biographical sketch, a list of areas of expertise and/or a link to their home page. REU/RET supplement requests should be submitted by March 31 each year.

The Environmental Health and Safety of Nanotechnology (Nano EHS) program provides support to examine and mitigate the environmental effects of nanotechnologies. Fundamental research is sought to understand, evaluate, and lessen the impact of nanotechnology on the environment and biological systems. The program emphasizes engineering principles underlying the environmental health and safety impacts of nanotechnology. Innovative methods related to clean nanomaterials production processes, waste reduction, recycling, and industrial ecology of nanotechnology are also of interest.

The Thermal Transport Processes program supports engineering research aimed at gaining a basic understanding of the thermal transport phenomena at nano/micro and macro scales in (1) cooling and heating of equipment and devices, (2) energy conversion, power generation and thermal energy storage and conservation, (3) the synthesis and processing of materials including advanced manufacturing, (4) the propulsion of air and land-based vehicles, and (5) thermal phenomena in biological systems.

The Fluid Dynamics program supports fundamental research and education on mechanisms and phenomena governing fluid flow. Proposed research should contribute to basic understanding; thus enabling the better design; predictability; efficiency; and control of systems that involve fluids. Encouraged are proposals that address innovative uses of fluids in materials development; manufacturing; biotechnology; nanotechnology; clinical diagnostics and drug delivery; sensor development and integration; energy and the environment. While the research should focus on fundamentals, a clear connection to potential application should be outlined.

The Particulate and Multiphase Processes program supports fundamental and applied research on phenomena governing particulate and multiphase processes, including flows of suspensions of particles, drops or bubbles, granular and granular-fluid flows, flow behavior of micro or nano-structured fluids, aerosol science and technology, and self- and directed-assembly processes involving particulates. Innovative research is sought that contributes to improving the basic understanding, design, predictability, efficiency, and control of particulate and multiphase processes with particular emphasis on: novel manufacturing techniques, multiphase systems of relevance to energy harvesting, multiphase transport in biological systems or biotechnology, and environmental sustainability.

The purpose of the NIH Summer Research Experience Program (referred to as the Summer Research Program) is to provide a high quality research experience for high school and college students and for science teachers during the summer academic break. The NIH expects that such programs will: help attract young students to careers in science; provide opportunities for college students to gain valuable research experience to help prepare them for graduate school; and enhance the skills of science teachers and enable them to more effectively communicate the nature of the scientific process to their students. The programs would also contribute to enhancing overall science literacy. Summer Research Programs that expand and complement existing summer educational and training programs are encouraged.

Research!America is pleased to announce an exciting new program to introduce and engage early-career scientists in research advocacy and science policy. The 2013 Research!America Advocacy Academy is a unique opportunity for postdoctoral fellows in the health and biomedical sciences to learn about how to best incorporate advocacy and effective communications into their role as a scientist. The 2013 class of up to 12 Research!America advocates will participate in a two-day Washington, DC, program from September 11-12, 2013. Participants will learn about the federal budget and appropriations process, tools for effective science communication and outreach as well as how to engage with elected representatives on scientific and research issues. The program includes visiting Capitol Hill to meet with policy makers and congressional staff members, providing participants with a first-hand experience advocating for health research. Rounding out this unique Washington experience, participants will attend Research!America's National Health Research Forum where top leaders in government, industry, academia and patient organizations engage in moderated conversations on issues of importance to the research ecosystem. Upon completion of the program, participants will become Science Advocates for Research!America. Advocates will remain engaged with Research!America staff, receive ongoing action alerts and learn about ways to involve their home institution's research community in effective science advocacy. All travel expenses (transportation, lodging and meals) will be provided and arranged by Research!America through an educational grant provided by Pfizer. This year's program is limited to 12 exceptional postdoctoral researchers with a dedicated interest in becoming active advocates for science.

The Materials Engineering and Processing (MEP) program supports fundamental research addressing the interrelationship of materials processing, structure, properties and/or life-cycle performance for targeted applications. Research proposals should be driven by the performance or output of the material system relative to the targeted application(s). Research plans driven by scientific hypotheses are encouraged when suitable. Materials in bulk form or focus on special zones such as surfaces or interfaces that are to be used in structural and/or functional applications are appropriate. All material systems are of interest including polymers, metals, ceramics, semiconductors, composites and hybrids thereof. Analytical, experimental, and numerical studies are supported and collaborative proposals with industry (GOALI) are encouraged.Areas of interest include: Functional Materials - materials that possess native properties and functions that can be controlled by external forces such as temperature, light, electric field, pH, etc. These include materials that exhibit properties such as electronic, magnetic, piezoelectric, ferroelectric, photovoltaic, chromogenic, shape memory, thermoelectric or self-healing, etc. Structural Materials - materials that, in service, bear mechanical load. Length scales from nano to meso to macro are of interest as are materials in the bulk or in special configuration such as thin film. These include materials such as metals, polymers, composites, biomaterials, ceramics, hybrids, cement, etc. Materials Processing - processes that convert material into useful form as either intermediate or final composition. These include processes such as extrusion, molding, casting, deposition, sintering, printing, etc. Research that addresses multi-scale and/or multi-functional materials systems is encouraged as is research in support of environmentally-benign manufacturing.

The MURI program supports basic research in science and engineering at U.S. institutions of higher education that is of potential interest to DoD. The program is focused on multidisciplinary research efforts where more than one traditional discipline interacts to provide rapid advances in scientific areas of interest to the DoD. As defined by the DoD, "basic research is systematic study directed toward greater knowledge or understanding of the fundamental aspects of phenomena and of observable facts without specific applications towards processes or products in mind. It includes all scientific study and experimentation directed toward increasing fundamental knowledge and understanding in those fields of the physical, engineering, environmental, and life sciences related to long-term national security needs. It is farsighted high payoff research that provides the basis for technological progress." (DoD 7000.14.R, vol. 2B, chap.5). DoD's basic research program invests broadly in many specific fields to ensure that it has early cognizance of new scientific knowledge. 

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative research proposals in the area of processes and technology for assembly of systems, components, and materials at millimeter scale or larger from nanometer scale constituents. Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.

Announced in June 2013 by U.S. Secretary of State John Kerry and former UK Foreign Secretary William Hague and formally launched in October 2013 by Rt Hon. David Willetts MP, the Global Innovation Initiative is a higher education partnership grant opportunity established between the United States and the United Kingdom aimed at strengthening multilateral research collaborations between universities in the U.S., UK, and other selected countries. The Global Innovation Initiative will award grants to university consortia focusing on science, technology, engineering, and mathematics (STEM)-related issues of global significance that foster cutting-edge multinational research and strengthen institutional international partnerships

This Funding Opportunity Announcement (FOA) solicits Phase I (R43) Small Business Innovative Research (SBIR) grant applications from small business concerns (SBCs) to develop and/or adapt novel technologies to enable the characterization of human exposures to engineered nanomaterials (ENMs) and to monitor or assess ENMs in diverse media ranging from biological samples to air and water.  

The Course Hero-Woodrow Wilson Fellowship for Excellence in Teaching will support rising stars in the academy who love teaching, demonstrate excellence as educators, and are making their mark as exceptional researchers, poised to shape their fields. Designed for young scholars working towards tenure, the Course Hero-WW Fellowship is a "genius grant" that will emphasize the balance between scholarly excellence and commitment to teaching practice that draws on new approaches to pedagogy, creating a new level of engagement for students in and beyond the classroom. In short, Fellows will be emerging heroes in their fields, on a clear trajectory to become great college educators. In its inaugural year, the Course Hero-WW Fellowship will identify five outstanding junior faculty members. Fellows will receive a one-year grant of $40,000-approximately $30,000 to support the engagement of a student assistant and the balance to be used for research and travel support. Exceptional candidates teach in ways that build student confidence and mastery of a subject; encourage critical thinking; explore foundational concepts through the lens of broader themes and global events; promote the power of learning communities beyond the classroom; leverage technology to complement the classroom experience; consider and serve different learning styles; prepare students for lifelong learning; and can serve as replicable teaching models for other educators. Selection takes place in June 2018. The five Fellows will be invited to attend the Course Hero Education Summit in July 2018, where their Fellowships will be announced.

The Research Experiences for Undergraduates (REU) program supports active research participation by undergraduate students in any of the areas of research funded by the National Science Foundation. REU projects involve students in meaningful ways in ongoing research programs or in research projects specifically designed for the REU program. This solicitation features two mechanisms for support of student research: (1) REU Sites are based on independent proposals to initiate and conduct projects that engage a number of students in research. REU Sites may be based in a single discipline or academic department or may offer interdisciplinary or multi-department research opportunities with a coherent intellectual theme. Proposals with an international dimension are welcome. (2) REU Supplements may be included as a component of proposals for new or renewal NSF grants or cooperative agreements or may be requested for ongoing NSF-funded research projects.

The Alfred P. Sloan Foundation makes grants on six broad subject matters, known within the Foundation as major program areas.  Basic Research STEM Higher Education Public Understanding of Science Economic Performance and the Quality of Life Select National Issues Civic Initiatives

The Theoretical Atomic, Molecular, and Optical Physics (TAMOP) program supports theoretical and computational research in all areas of atomic structure, the molecular structure of small molecules, electron, and atomic collisions, photoionization and photodetachment of electrons from atoms and small molecules, time-dependent interactions with atoms and small molecules, quantum optics, ultracold phenomena in Bose and Fermi gases, and quantum information. Investigations primarily directed toward a theoretical understanding of larger molecules or condensed matter systems should be directed toward the appropriate programs in the Division of Chemistry or the Division of Materials Research.

This Funding Opportunity Announcement (FOA) requests applications for the development of medium- to high-throughput "omics" technologies that can be used to explore human pancreatic tissues with single cell- or near single cell- resolution. Successful applicants will join the Consortium on Beta cell Death and Survival (CBDS), whose mission is to identify the mechanisms of beta cell stress and destruction central to the development of Type 1 Diabetes (T1D) in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and preventing the progression towards autoimmunity. CBDS is part of the Human Islet Research Network (HIRN).

This Funding Opportunity Announcement (FOA) requests applications for the development of medium- to high-throughput "omics" technologies that can be used to explore human pancreatic tissues with single cell- or near single cell- resolution. Successful applicants will join the Consortium on Beta cell Death and Survival (CBDS), whose mission is to identify the mechanisms of beta cell stress and destruction central to the development of Type 1 Diabetes (T1D) in humans, with the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and preventing the progression towards autoimmunity. 

The Office of Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE) hereby announces its interest in receiving research applications for novel imaging and measurement technologies for biological systems science. This Funding Opportunity Announcement (FOA) will consider applications for the development of novel imaging instrumentation and measurement technologies that support the integrative analysis of communication among subcellular compartments, between individual microbial cells and within multicellular communities/plant tissues. The goal is to develop in situ, dynamic and nondestructive approaches to enable multifunctional imaging, quantitative flux measurements, and multiscale integrative analysis of bioenergy-relevant plant and microbial systems.