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This initiative will support basic and/or translational research to address knowledge gaps that hinder the development and regulation of bacteriophage used to prevent and treat bacterial infections. While individual phage products may be used to assess the research questions, the primary intent is to increase the overall knowledge base on bacteriophage as products. NIAID offers other funding mechanisms for the preclinical and clinical development of phage and other non-traditional antibiotic products.

A major goal of research on suicide is to improve our understanding of who is at most risk, why people transition from suicidal thoughts to action, and when to intervene (Prioritized Research Agenda for Suicide Prevention, Short-term Objective 1.C). Risk is a dynamic process and suicide attempts are often preceded by acute stressors. While many studies of suicide risk focus on emotion dysregulation, fewer studies have examined arousal and regulation and how these domains dynamically shape emotional and cognitive functions such as response to reward, frustrative non-reward, cognitive flexibility and control, or decision-making. Very few studies in the NIMH portfolio on suicide risk have focused on proximal risk. This Funding Opportunity Announcement (FOA) will fund research that will address these gaps by providing an understanding of the mechanisms of how dysregulation interacts with Cognition and Negative and Positive Valence in order to determine time-varying risk, and then to identify modifiable targets for timely interventions during highrisk periods.

Today's workers risk daily exposure to coronavirus while getting their jobs done. It is in this moment of a global pandemic that we see how the gains of the 20th century economy have left behind the very workers who are essential to keeping it afloat. We must seize this opportunity to redress these wrongs. We must extend protection, recourse, and safe working conditions to all workers. That's why our Summer 2020 cycle of The Innovation Fund will call for applications specifically about the topic of: Worker Health & Safety.   For Summer 2020, we're calling for new ideas for and from workers and leaders who are listening to them. Innovations can be:  Policy experiments Programs that build worker agency Multi-stakeholder partnerships  Tools for relaying real-time information on safety rules and regulations  Technology enabled health and safety solutions

The purpose of this initiative is to encourage research that investigates the role of molecular epigenetic or non-coding RNA regulatory pathways in the development or maintenance of chronic pain. Ultimately research in the area will provide foundational knowledge that can be exploited to develop novel and non-addictive pain medications.