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The intersection of justice and community-based health systems is a critical target for addressing the opioid crisis. The National Institute on Drug Abuse intends to establish the Justice Community Opioid Innovation Network (JCOIN) using the cooperative agreement mechanism. The purpose of the network is to establish a national consortium of investigators examining promising interventions and other approaches that can improve the capacity of the justice system to effectively respond to the opioid epidemic. The structure of the network shall consist of three highly integrated components - (1) Clinical Research Centers (each center will propose a study to be executed in at least 5 research performance sites), (2) a single, central Coordination and Translation Center, and (3) a single, central Methodology and Advanced Analytics Resource Center. This FOA solicits applications for Clinical Research Centers. This FOA runs in parallel with companion FOAs that seek applications for a single Coordination and Translation Center (RFA-DA-19-024), and a single Methodology and Advanced Analytics Resource Center (RFA-DA-19-023).

The NIEHS is establishing an infrastructure, the Human Health Exposure Analysis Resource (HHEAR) as a continuation of the Children's Health Exposure Analysis Resource (CHEAR). The goal of this consortium is to provide the research community access to laboratory and statistical analyses to add or expand the inclusion of environmental exposures in their research and to make that data publicly available as a means to improve our knowledge of the comprehensive effects of environmental exposures on human health throughout the life course. This FOA solicits Laboratories (Lab Hubs) providing a comprehensive suite of analysis of environmental exposures in samples such as dust, soil, and drinking water related to the immediate environment of individuals and linked to health endpoints. Each Hub will incorporate a developmental core to develop novel measures for environmental samples, expanding the number of current, commonly measured analytes, and developing new methods for detecting analytes in other environmental samples and providing additional insight into the sources of exposures that influence human health. The Environmental Monitoring Lab will also serve as a 'clearinghouse for evaluation and provision of emerging tools and technologies for personal exposure assessment to the client community.

The NIEHS and partnering Institutes and Centers are establishing an infrastructure, the Human Health Exposure Analysis Resource (HHEAR) as a continuation of the Children's Health Exposure Analysis Resource (CHEAR). The goal of this consortium is to provide the research community access to laboratory and statistical analyses to add or expand the inclusion of environmental exposures in their research and to make that data publicly available as a means to improve our knowledge of the comprehensive effects of environmental exposures on human health throughout the life course. This FOA solicits Laboratories (Lab Hubs) that can provide comprehensive measurement of the exposome using untargeted approaches (such as metabolomics using libraries enriched for environmental exposure biomarkers) for biological samples derived from extant or ongoing human health studies in the NIH extramural research community. Each Hub will incorporate an administrative core and a developmental core to improve the ability of untargeted platform to detect a wide range of environmental exposures and endogenous changes in response to environmental influences in a variety of biological matrices.

The purpose of this Funding Opportunity Announcement (FOA) is to support the development and validation of modeling and simulation methods and related tools to examine HIV transmission dynamics, make epidemic projections, and estimate the impact of HIV treatment and prevention. Investigators are expected to share these resources with other researchers. Funding for the final fourth year is dependent upon achieving applicant-proposed and pre-award negotiated Go/No-Go criteria.

The purpose of this NOFO is to provide funding and technical assistance for PEPFAR countries to establish HIV recent infection surveillance to detect recent infections, monitor trends in the HIV epidemic, identify hot spots associated with recent HIV transmission, and inform programmatic interventions to reach epidemic control. Point-of-care tests for recent infection distinguish between recent (HIV seroconversion in the last 6 months, on average) and non-recent HIV infection and provide results within minutes. These data may be linked to HIV case-based surveillance for ongoing epidemic monitoring and used by programs to provide enhanced counselling for immediate ART initiation, prioritize index testing, and intervene to prevent HIV transmission. This NOFO will require a multi-disciplinary team with expertise in surveillance, laboratory, prevention, HIV testing services, health informatics, data management, data analytics, and supply chain to support the planning, implementation, and impact evaluation of this PEPFAR priority activity.

The NIDCR-funded FaceBase data repository and knowledgebase (www.facebase.org) was established to advance craniofacial research by creating comprehensive datasets on craniofacial development and dysmorphologies and disseminating them to the wider craniofacial research community. Since FaceBase's inception, the data management and integration hub has been charged with the critical functions of collecting datasets and analytic tools developed by dataset-generating spoke projects, curating and integrating those resources, and disseminating them. This Request for Applications (RFA) is a limited competition for renewal applications for the Data Management and Integration Hub. As in the past, the FaceBase 3 hub will continue to be responsible for integration and presentation of existing FaceBase datasets, development or adoption of new approaches for data search and visualization, and outreach to the wider craniofacial research community. In addition, the hub will assume an important new mission that of working with investigators within the craniofacial research community to make their datasets compatible with FaceBase's data models, curating and integrating these new datasets with those already held by FaceBase.

This Funding Opportunity Announcement (FOA) encourages applications to develop valid markers to assess the activity of fundamental aging mechanisms in humans that may influence the risk and progression of multiple aging conditions. Projects are encouraged that focus on selected mechanism(s) that may regulate aging changes, assess multiple possible markers for these mechanisms, test methods to improve their measurement properties, characterize their variability among individuals of differing ages and within the same age cohort, and assess their relationships in humans to in vivo functions influenced by the mechanism(s) under study. It is strongly encouraged that each project includes an interdisciplinary research team with expertise, as needed, in the biology of their selected mechanism(s), biomedical aging research, clinical pathology including laboratory assays, imaging methods, human cohort studies, tissue banking, biorepository resources, and statistics. Though the principal focus of the initiative is on development of markers in humans, studies in laboratory animals may also be conducted when necessary for the development of human markers, and potential development of parallel laboratory animal markers of a given mechanism.

This NOFO will support achievement of national targets for 2018 antiretroviral therapy (ART) scale-up towards the UNAIDS Fast Track Targets in Ukraine. The recipient will implement innovative and effective recruitment and case management models for persons who inject drugs (PWID) and men who have sex with men (MSM) at the community level. These innovative changes will increase uptake of HIV community based testing and increase ART initiation for these populations. The recipient will pilot risk network-based testing using point-of-care recency assays to link recently infected PWID to care. The project will focus on the six regions with the highest HIV burden (Dnipropetrovsk, Mykolayiv, Odesa, government controlled areas (GCA) of Donetsk, Kyiv City, and Kherson) and continue to work in six additional medium burden oblasts (Cherkasy, Poltava, Chernihiv, Zaporizhzhya, Kirovohrad, and Kyiv). The recipient will also increase the capacity of the Government of Ukraine’s Center for Public Health (CPH) and regional monitoring and evaluation (M&E) centers specialists to conduct data analysis using statistical software and build institutional capacity to conduct economic evaluations of HIV interventions. Illustrative strategic information (SI) activities include development of trainings to support the Ministry of Health (MOH) and the newly established CPH in using statistical software, routine analysis of surveillance data, study design, and research protocol development.

The purpose of this Notice of Funding Opportunity (NOFO) is to support innovative research to develop and apply computational tools and mathematical methods for: 1) modeling the spread of pathogens that cause healthcare-associated infections (HAIs) and related antimicrobial resistant (AR) infections; 2) predicting outbreaks of HAI pathogens and trends in the burden of antimicrobial resistant and susceptible HAIs; and 3) investigating the effectiveness of intervention strategies. The models should be developed with the intent that they will be tools for researchers, policymakers, or public health workers who want to better understand and respond to HAIs in the United States. This NOFO will also create a network of leaders in the fields of HAI and AR modeling that will be a resource for informing the development of relevant evidence-based policy. MInD-Healthcare will provide a network of leading modelers to respond to evolving public health needs and emergencies in healthcare settings.