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The purpose of the R01 grant program is to develop an understanding of the risks and conditions associated with occupational diseases and injuries, to explore methods for reducing risks and preventing or minimizing exposure to hazardous conditions in the workplace, and to translate significant scientific findings into prevention practices and products that will effectively reduce work-related illnesses and injuries. Applicants must concisely describe the occupational health burden(s) being addressed in their proposal while also linking the need for the proposed research activities to planned outputs that will help address or alleviate this burden. Applicants should clearly articulate the anticipated impacts of the proposed research, both during the project period and beyond.