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The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Funding Opportunity Announcement is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the appropriate Clinical Trials Required FOA. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

The purpose of this funding opportunity announcement (FOA) is to stimulate research on a wide range of topics related to neonatal and pediatric resuscitation. Possible topics may include, but are not limited to: fetal-neonatal transitional cardiovascular and pulmonary physiology, optimizing steps of resuscitation, management of third stage of labor and its effect on the fetus, resuscitation of children with malformations, effect of resuscitation on long-term outcomes and post-resuscitation practices. Applications can include epidemiological studies, studies utilizing fetal-neonatal animal models, computer or other information-technology-based simulations or study designs, clinical observational studies, analyses of pre-existing national or regional datasets, opportunistic studies, prospective randomized controlled trials, or any combinations thereof. It is anticipated that the results from well-conducted studies will enable translation of knowledge into evidence-based resuscitation practices ensuring a optimal short- and long-term outcomes for all newborn infants and children.

NIJ intends to fund a sub-study involving several of the 21 NIDA-funded ABCD Study sites to include measures of delinquency and victimization in their investigations. The sub-study will address key questions on the interactions between substance use, brain development, delinquency, and victimization. Funding from this award will support a coordinating center to plan for and collect the first wave of data for the sub-study. NIJ intends to fund subsequent waves of data collection via supplements to this award in order to follow the children into young adulthood. NIJ anticipates making yearly supplemental awards under this solicitation for up to approximately 10 years depending on the duration of the main, NIDA-funded ABCD study.

CDC has previously implemented population based case control studies of birth defects known as the National Birth Defects Prevention Study (NBDPS) for births from 1997-2011 and the Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS I) which started with births in 2014 and is ongoing. The purpose of BD-STEPS II is to identify causes of birth defects and stillbirths using epidemiologic and genetic research methods and provide information that could be translated into public health prevention messages. The activities under this NOFO will be supported by two separate but related funding components: Component A. BD-STEPS II Core. To support the continuation of the epidemiological and genetic research capability of the Centers for Birth Defects Research and Prevention (CBDRP) through BD-STEPS. The intent of this BD-STEPS II is to carry out BD-STEPS using the same basic study design currently used by grantees with a focus on the key areas of: (1) maternal chronic disease and their treatments; (2) infectious disease in pregnancy; and (3) medications. In BD-STEPS II we will add focus on infectious causes of birth defects, and pilots will be conducted to determine feasibility of medication use validation. Both new sites and current BD-STEPS sites are encouraged to apply for this component. Component B. BD-STEPS stillbirth. To support the continued exploration of modifiable risk factors for stillbirths. The intent of this component is to conduct the BD-STEPS II Core interview and a follow-up interview with mothers affected by stillbirths and mothers of livebirths to conduct a case-control study of stillbirth risk factors. To be funded for Component B, applicants must have a responsive application for Component A and receive Component A funding. Both new sites and current BD-STEPS sites are encouraged to apply for this component.

Non-clinical studies in juvenile animal models have shown that exposure to some anesthetics and sedatives is associated with neurodegenerative changes in the central nervous system, as well as memory and learning deficits. Anesthetic agents that have been specifically implicated are NMDA receptor antagonists, such as ketamine, and GABA agonists, such as sevoflurane. The anesthesia community and the FDA acknowledge that there are insufficient human data to either support or refute the clinical relevance of these findings for pediatric patients. Therefore, numerous non-clinical and clinical studies are needed to assess the effect of anesthetics and sedatives on the developing human brain, including long-term studies in neonates and young children.  However, the planning and performance of the numerous studies needed to address the aforementioned issues will involve enormous challenges in terms of design, assurance of validity and reliability of the outcome measures, and ethical considerations. It is unlikely that any one entity will possess the necessary expertise and resources to accomplish all the work needed to address the issues in an expeditious manner.  FDA seeks under its Pediatric Anesthesia Safety Initiative (PASI), to encourage and facilitate scientific collaboration among multiple stakeholders within a public-private partnership (PPP) framework, and to support the conduct of non-clinical and clinical studies to answer unknown questions regarding the effects of anesthetics and sedatives in the pediatric population.

The purpose of this funding opportunity is to establish a program of research to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). Given the prevalence and associated morbidity and mortality of MODS in children, the current lack of understanding underscores the need for more exploratory research. Possible topics of study include, but are not limited to, the epidemiology, pathophysiology, monitoring, and treatment of MODS. Studies that assess specific etiologies associated with MODS including, but not limited to, sepsis, trauma, acute respiratory distress syndrome, inborn errors of metabolism, burns, cancer, transplantation and congenital heart disease are encouraged. Applications may include any appropriate study design ranging from basic science animal models through small prospective randomized controlled trials. The intent of this R21 funding initiative is to encourage exploratory and developmental research projects by providing support for the early and conceptual stages of research projects addressing these topics. These studies may incur considerable research risk in efforts to make important breakthroughs in the understanding, prevention and treatment of MODS in children. Projects of limited cost or scope that use widely accepted approaches and methods within well-established fields are better suited for the R03 small grant activity code. It is hoped that the results of this exploratory research will translate into improved clinical outcomes for children with, and at risk for MODS.

The NEA Foundation, the philanthropic arm of the National Education Association, is a public charity supported by contributions from educators' dues, corporate sponsors, and others. The foundation supports student success by helping public school educators work with key partners to build strong systems of shared responsibility. As part of an effort to achieve this goal, the foundation is inviting applications for its Learning and Leadership Grants program. The program provides support to public school teachers, public education support professionals, and/or faculty and staff in public institutions of higher education through grants to individuals to fund participation in high-quality professional development experiences, such as summer institutes or action research; or grants to groups for collegial study activities, including study groups, action research, lesson study, or mentoring experiences for faculty or staff new to an assignment. The grant amount is $2,000 for individuals and $5,000 for groups engaged in collegial study. All $5,000 group grant applicants must include partner information. To be eligible, applicants must be a public school educator in grades pre-K-12; a public school education support professional; or a faculty or staff member at a public higher education institution. The foundation encourages applications from education support professionals. Preference will be given to members of the National Education Association.

The NEA Foundation, the philanthropic arm of the National Education Association, is a public charity supported by contributions from educators' dues, corporate sponsors, and others. The foundation supports student success by helping public school educator's work with key partners to build strong systems of shared responsibility. As part of an effort to achieve this goal, the foundation is inviting applications for its Learning and Leadership Grants program. The program provides support to public school teachers, public education support professionals, and/or faculty and staff in public institutions of higher education through grants to individuals to fund participation in high-quality professional development experiences, such as summer institutes or action research; or grants to groups fund collegial study, including study groups, action research, lesson study, or mentoring experiences for faculty or staff new to an assignment. The grant amount is $2,000 for individuals and $5,000 for groups engaged in collegial study. All $5,000 group grant applicants must include partner information. To be eligible, applicants must be public school educators in grades PreK-12; public school education support professionals; or faculty and staff at public higher education institutions. The foundation encourages education support professionals to apply. Preference will be given to members of the National Education Association.

This Funding Opportunity Announcement (FOA) solicits applications for planning and initial development of a large scale multi-site research study to prospectively examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally through childhood (e.g., age 9-10), and the long-term impacts of pre/postnatal drug (expected oversampling for opioid prenatal exposures) and adverse environmental exposures on brain and behavioral health and risk for substance use and mental disorders. In addition to planning and testing the feasibility of study designs, awardees will be expected to participate in 2-3 grantee meetings to share lessons learned and to begin to form collaborations needed to establish the network of sites that will conduct this study.  

NIDA and the following NIH Institutes, Centers, and Programs, NIAAA, NICHD, NIMH, NIMHD, NINDS, and ECHO intend to publish a funding opportunity announcement to solicit applications to propose and test the feasibility of research study designs addressing the impact of pre- and postnatal substance exposure (including opioids, opioid treatment medications, cannabis, alcohol, tobacco, other prescription or illicit substances, alone or in combination) on brain, social, and behavioral development, mental illness, and substance use. In addition to planning and testing the feasibility of study designs, awardees will be expected to participate in several grantee meetings to share lessons learned and begin to develop the network of sites needed to conduct this study.

The Adolescent Brain Cognitive Development (ABCD) Study is collecting data on health and mental health, cognitive function, substance use, cultural and environmental factors, and brain structure and function from youth starting when they are 9-10 years-old repeatedly for 10 years and makes that data available to the scientific community through the NIMH Data Archive. The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications proposing the analysis of this public use dataset to increase knowledge of adolescent health and development. More information about the ABCD Study may be found on the ABCD Study web page (www.abcdstudy.org).

This encompasses basic biological processes governing differentiation and development involving both human and animal model systems, genetics and genomics of these processes, clinical studies, reproductive health and environmental toxicology. Social and behavioral studies are encouraged concerning cognitive and behavioral risks that affect outcomes of pregnancy, the perinatal period, and subsequent child development. The latter may involve family units and those genes, toxicants and social determinants that adversely affect language or behavior.

This encompasses basic biological processes governing differentiation and development involving both human and animal model systems, genetics and genomics of these processes, clinical studies, reproductive health and environmental toxicology. Social and behavioral studies are encouraged concerning cognitive and behavioral risks that affect outcomes of pregnancy, the perinatal period, and subsequent child development. The latter may involve family units and those genes, toxicants and social determinants that adversely affect language or behavior.

This initiative encourages research that targets the reduction of health disparities among children. Specific targeted areas of research include biobehavioral studies that incorporate multiple factors that influence child health disparities such as biological (e.g., genetics, cellular, organ systems), lifestyle factors, environmental (e.g., physical and family environments) social (e.g., peers), economic, institutional, and cultural and family influences; studies that target the specific health promotion needs of children with a known health condition and/or disability; and studies that test and evaluate the comparative effectiveness of health promotion interventions conducted in traditional and nontraditional settings.

This initiative encourages research that targets the reduction of health disparities among children. Specific targeted areas of research include biobehavioral studies that incorporate multiple factors that influence child health disparities such as biological (e.g., genetics, cellular, organ systems), lifestyle factors, environmental (e.g., physical and family environments) social (e.g., peers), economic, institutional, and cultural and family influences; studies that target the specific health promotion needs of children with a known health condition and/or disability; and studies that test and evaluate the comparative effectiveness of health promotion interventions conducted in traditional and nontraditional settings.

The purpose of this funding opportunity announcement (FOA) is to provide competitive grant funds for regional partnership grants (RPGs) to improve the well-being of children affected by substance abuse. These targeted grants will be awarded to regional partnerships that provide through interagency collaboration and integration of programs and services, activities and services that are designed to increase the well-being of, improve permanency outcomes for, and enhance the safety of children who are in out-of-home placements or are at risk of entering out-of-home placements as a result of a parent's or caretaker's substance abuse. Applicants are expected to have a collaborative structure in place that is capable of building a region's capacity to meet a broad range of needs for families involved with both substance abuse treatment and the child welfare system. Per the legislative requirements, RPGs are required to select and report on performance indicators and evaluation measures to increase the knowledge that can be gained from the program. Partnerships will: Use specific, well-defined, and evidence-based programs that are also trauma-informed and targeted to the identified population; Conduct an evaluation that is sufficiently rigorous to contribute to the evidence base on service delivery, outcomes and costs associated with the project's chosen interventions; and Participate in the national cross-site evaluation, which includes an implementation and partnership study, an outcomes study, and an impact study.

Fahs-Beck Fund for Research and Experimentation is accepting applications from behavioral or psychological research studies based in the United States or Canada. Through its Faculty/Post-Doctoral Fellows program, the fund will award grants of up to $20,000 in support of studies aimed at developing, refining, evaluating, or disseminating innovative interventions designed to prevent or ameliorate major social, psychological, behavioral, or public health problems affecting children, adults, couples, families, or communities. The fund will also consider studies that have the potential for adding significantly to knowledge about such problems. Projects must be focused on the United States or Canada or on a comparison between the U.S. or Canada and one (or more) other country. To be eligible, applicants must be a faculty member at an accredited college or university or an individual affiliated with an accredited human service organization that is tax exempt under Section 501(c)(3) of the Internal Revenue Code. In addition, the principal investigator must have an earned doctorate in a relevant discipline and relevant experience.

Established in 1962, the Spencer Foundation is dedicated to the belief that research is necessary to the improvement of education. To that end, the foundation supports high-quality investigations of education through its research programs and to the strengthening and renewal of the educational research community through its fellowship/training programs and related activities. To that end, the foundation is accepting proposals through its Small Research Grants Program from education research projects. In keeping with the foundation's mission, the program aims to fund academic work that will contribute to the improvement of education, broadly conceived. Examples of previously funded projects include an experimental study of how college students use visual representations in solving math problems; a study exploring the process of racial and rural identity formation among African-American high-school students who attend de facto segregated schools in the rural South; and a mixed-methods study focused on the different types of knowledge novice and experienced teachers draw on in teaching reading comprehension. To be eligible, principal investigators and co-PIs must have an earned doctorate in an academic discipline or professional field, or appropriate experience in an education research-related profession. In addition, the PI must be affiliated with a college, university, school district, nonprofit research facility, or nonprofit cultural institution that is willing to serve as the fiscal agent should a grant be awarded.

The purpose of this funding opportunity announcement (FOA) is to establish a program of research to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). Given the prevalence and associated morbidity and mortality of MODS in children, the current lack of understanding underscores the need for more basic, exploratory and longitudinal research. Possible topics of study include, but are not limited, to the epidemiology, pathophysiology, monitoring, and treatment of MODS. Studies that assess specific etiologies associated with MODS including, but not limited to, sepsis, trauma, acute respiratory distress syndrome, inborn errors of metabolism, burns, cancer, transplantation and congenital heart disease are encouraged. Applications may include any appropriate study designs ranging from basic science and animal models through prospective randomized controlled trials. It is hoped that as a result of research supported through this funding opportunity, outcomes will improve both in terms of the prevention and treatment of MODS in children.

The purpose of this funding opportunity announcement (FOA) is to establish a program of research to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). Given the prevalence and associated morbidity and mortality of MODS in children, the current lack of understanding underscores the need for more basic, exploratory and longitudinal research. Possible topics of study include, but are not limited, to the epidemiology, pathophysiology, monitoring, and treatment of MODS. Studies that assess specific etiologies associated with MODS including, but not limited to, sepsis, trauma, acute respiratory distress syndrome, inborn errors of metabolism, burns, cancer, transplantation and congenital heart disease are encouraged. Applications may include any appropriate study designs ranging from basic science and animal models through prospective randomized controlled trials. It is hoped that as a result of research supported through this funding opportunity, outcomes will improve both in terms of the prevention and treatment of MODS in children.

Established in 1962, the Spencer Foundation is dedicated to the belief that research is necessary to the improvement of education. To that end, the foundation supports high-quality investigations of education through its research programs and the strengthening and renewing of the educational research community through its fellowship and training programs and related activities. Through its Small Research Grants Program, the foundation is accepting research proposals for education research projects. In keeping with the foundation's mission, the program aims to fund academic work that will contribute to the improvement of education, broadly conceived. Examples of previously funded projects include an experimental study of how college students use visual representations in solving math problems; a study exploring the process of racial and rural identity formation among African-American high-school students who attend de facto segregated schools in the rural South; and a mixed-methods study focused on the different types of knowledge novice and experienced teachers draw on in teaching reading comprehension. The program awards grants of up to $50,000. To be eligible, principal investigators and co-PIs must have an earned doctorate in an academic discipline or professional field, or appropriate experience in an education research-related profession. In addition, the PI must be affiliated with a college, university, school district, nonprofit research facility, or nonprofit cultural institution that is willing to serve as the fiscal agent if a grant is awarded.