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Risky alcohol use can result in a wide range of negative health and social consequences and over time, can result in serious medical conditions, such as hypertension, liver disease, and various types of cancer. Prenatal alcohol exposure can result in fetal alcohol spectrum disorders in the developing baby and is associated with other poor birth outcomes, such as miscarriage, stillbirth, preterm birth, and sudden infant death syndrome.

The Centers for Disease Control and Prevention (CDC) proposes to allocate funds to implement Notice of Funding Opportunity (NOFO) PS18-1807, “Promoting Adolescent Health through School-Based HIV/STD Prevention.” The project period will be 5 years, with a 12-month budget period and an anticipated award date of August 1, 2018. This NOFO will provide support for education agencies and NGOs to help school districts and schools develop and implement sustainable program activities to: 1) Reduce HIV infection and other STDs among adolescents; and 2) Reduce disparities in risk for HIV infection and other STD infection. Throughout the 5-year cooperative agreement, awardees will conduct activities demonstrated to improve the health of middle school and high school students by collection and use of quality surveillance data, the implementation of effective prevention practices, and demonstration and evaluation of innovative strategies within their jurisdictions.

This funding opportunity announcement (FOA) invites applications from U.S. institutions to support Research Units (RUs) within the Global Network for Women's and Children's Health Research at NICHD.  RUs will consist of U.S.-based research centers applying in partnership with research centers in low income countries as defined by the World Bank.  The RUs within the Global Network will participate in addressing the major causes of maternal, neonatal, infant, and early childhood morbidity and mortality through the conduct of clinical research.  The grantees will become part of a cooperative network in scientific partnership with the NIH to conduct multi-enter observational studies and randomized clinical trials evaluating disease process, health and wellness outcomes, and results from interventions in resource-poor settings.      

This funding opportunity announcement (FOA) invites applications from U.S. institutions to support Research Units (RUs) within the Global Network for Womens and Childrens Health Research at NICHD. RUs will consist of U.S.-based research centers applying in partnership with research centers in low income countries as defined by the World Bank. The RUs within the Global Network will participate in addressing the major causes of maternal, neonatal, infant, and early childhood morbidity and mortality through the conduct of clinical research. The grantees will become part of a cooperative network in scientific partnership with the NIH to conduct multi-enter observational studies and randomized clinical trials evaluating disease process, health and wellness outcomes, and results from interventions in resource-poor settings.

The intended goal of this FOA is to facilitate the development, production, and distribution of pediatric medical devices. Although the FOA is issued by the FDA's Office of Orphan Products Development, the grant application is intended to encompass devices for all pediatric diseases and conditions, not just those that are rare. Applicants will request funding to serve as a nonprofit consortium to provide expert advising and support services to innovators of pediatric medical devices. The advising and services will focus on the total product life cycle for medical devices from concept, through pre-market development, to commercialization, and replacement by subsequent generation of devices.

The purpose of this funding opportunity announcement (FOA) is to support hypothesis-driven research of prenatal and pediatric hydrocephalus. This FOA intends to support hydrocephalus research projects that examine the developmental etiology (intrinsic factors including genetics) and acquired etiology (extrinsic factors including hemorrhage and infection) of prenatal and/or pediatric hydrocephalus. Studies should focus on understanding the molecular, cellular and developmental mechanisms involved in the pathogenesis of prenatal and/or pediatric hydrocephalus.

To that end, the foundation is accepting applications for research projects aimed at identifying solutions to common everyday issues and problems in the field of children's health and nutrition. Of particular interest to the foundation are projects offering substantial promise of meaningful advances in prevention and treatment of diseases and those with broad and general applicability.

The Centers for Disease Control and Prevention (CDC), Early Hearing Detection and Intervention (EHDI) program supports the success of all children who are deaf or hard of hearing (D/HH) in the United States by helping to ensure they receive a newborn screening, early diagnosis, and timely intervention services. Without timely screening, diagnosis and intervention, children who are D/HH lose valuable time in gaining the skills that will put them on a trajectory to have language on par with their hearing peers in kindergarten and be ready to succeed in school. Additionally, among children who are D/HH, delays in language development are more difficult to remediate with late diagnosis and intervention. While collaborative efforts by CDC, states, and other partners have helped lead to the early identification of thousands of children who are D/HH each year, their developmental and language outcomes are often unknown, and these data are not routinely collected by CDC or state EHDI programs. Furthermore, it is currently unclear what actions beyond early identification should be taken by public health to help reduce adverse consequences of hearing loss and ensure that children who are D/HH are ready for success in early childhood. The current lack of public health capacity to document and assess the intervention services and associated outcomes of early-identified children who are D/HH at the state and national level makes it challenging to: Assess the developmental progress to ensure all children who are D/HH are achieving age-appropriate milestones and are ready for success in early childhood; Identify strategies, in addition to those beyond early identification, to help assess and reduce adverse consequences of hearing loss; Assess and document the success and impact of EHDI activities across the United States.

The Runaway and Homeless Youth Program's Basic Center Program (BCP) provides temporary shelter and counseling services to youth who have left home without permission of their parents or guardians, have been forced to leave home, or other homeless youth who might otherwise end up in the law enforcement or in the child welfare, mental health, or juvenile justice systems. BCPs work to establish or strengthen community-based programs that meet the immediate needs of runaway and homeless youth and their families. BCPs provide youth under 18 years of age with emergency shelter, food, clothing, counseling and referrals for health care. BCPs can provide up to 21 days of shelter for youth and seeks to reunite young people with their families, whenever possible, or to locate appropriate alternative placements. Additional services may include: street-based services; home-based services for families with youth at risk of separation from the family; drug abuse education and prevention services; and at the request of runaway and homeless youth, testing for sexually transmitted diseases.

The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate tools and resources to facilitate the detailed analysis of brain microconnectivity. Novel and augmented techniques are sought that will ultimately be broadly accessible to the neuroscience community for the interrogation of microconnectivity in healthy and diseased brains of model organisms and humans. Development of technologies that will significantly drive down the cost of connectomics would enable routine mapping of the microconnectivity on the same individuals that have been analyzed physiologically, or to compare normal and pathological tissues in substantial numbers of multiple individuals to assess variability.  Advancements in both electron microscopy (EM) and super resolution light microscopic approaches are sought. Applications that propose to develop approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged. Proof-of-principle demonstrations and/or reference datasets enabling future development are welcome, as are improved approaches for automated segmentation and analysis strategies of neuronal structures in EM images.

The purpose of this funding opportunity announcement (FOA) is to establish a program of research to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). Given the prevalence and associated morbidity and mortality of MODS in children, the current lack of understanding underscores the need for more basic, exploratory and longitudinal research. Possible topics of study include, but are not limited, to the epidemiology, pathophysiology, monitoring, and treatment of MODS. Studies that assess specific etiologies associated with MODS including, but not limited to, sepsis, trauma, acute respiratory distress syndrome, inborn errors of metabolism, burns, cancer, transplantation and congenital heart disease are encouraged. Applications may include any appropriate study designs ranging from basic science and animal models through prospective randomized controlled trials. It is hoped that as a result of research supported through this funding opportunity, outcomes will improve both in terms of the prevention and treatment of MODS in children.

This notice solicits applications for the R40 Maternal and Child Health (MCH) Field-Initiated Innovative Research Studies (FIRST) Program. The purpose of the MCH FIRST Program grant is to advance the health and wellbeing of MCH populations by supporting innovative, applied, and translational intervention[1] research studies on critical issues affecting MCH populations. [1] For the purpose of this NOFO, an "intervention" is defined to include behavioral, social, or structural / health systems approaches, as well as combination applied clinico-medical and behavioral, social, or structural / health system approaches that contribute to the prevention of diseases or improvement of health (including clinical) outcomes for mothers, children and families at a population level.

The purpose of this funding opportunity announcement (FOA) is to establish a program of research to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). Given the prevalence and associated morbidity and mortality of MODS in children, the current lack of understanding underscores the need for more basic, exploratory and longitudinal research. Possible topics of study include, but are not limited, to the epidemiology, pathophysiology, monitoring, and treatment of MODS. Studies that assess specific etiologies associated with MODS including, but not limited to, sepsis, trauma, acute respiratory distress syndrome, inborn errors of metabolism, burns, cancer, transplantation and congenital heart disease are encouraged. Applications may include any appropriate study designs ranging from basic science and animal models through prospective randomized controlled trials. It is hoped that as a result of research supported through this funding opportunity, outcomes will improve both in terms of the prevention and treatment of MODS in children.

The purpose of this funding opportunity announcement (FOA) is to foster research on the unique perspectives, needs, wishes, and decision-making processes of adolescents and young adults (AYA; defined by the World Health Organization and the Centers for Disease Control and Prevention as youth between 12 - 24 years of age) with serious, advanced illnesses; and research focused on specific end-of-life/palliative care (EOLPC) models that support the physical, psychological, spiritual, and social needs of AYA with serious illness, their families and caregivers.

The mission of the Hearing Health Foundation is to prevent and cure hearing loss and tinnitus through groundbreaking research and promote hearing health. HHF envisions a world where people can enjoy life without hearing loss and tinnitus. To advance this mission, the foundation has issued a Call for Applications for its 2018 Emerging Research Grants program for projects designed to explore new avenues in specified topic areas of hearing and balance science. For the 2018 ERG cycle, grants of up to $30,000 will be awarded for research in seven priority areas, including general hearing health, central auditory processing disorders, hearing loss in children, hyperacusis, Ménière's disease, tinnitus, and Usher's syndrome.

The Fund recognizes that young investigators may find it difficult to remain in pediatric research because of a lack of funding. Therefore, the purpose of this program is to encourage the development of medical research in child health by awarding small grants to new researchers, helping them gain a foothold in this important area. The goal is to fund applicants who will go on to be independent investigators. The Fund will make up to 30 awards total with two funding cycles (15 awards each). The Fund is open to a wide variety of research topics. We do not focus on a particular ​disease, but all our funded projects deal directly with children's health. In the Early Career Award Program, the Fund is particularly interested in applicants that show great potential to impact that field of children's health through medical research. Both an applicant's aptitude and inclination toward research are considered. The quality of the mentor and the mentoring relationship are also considered to be important predictors of success.

The foundation awards grants for research focused on issues faced by care providers that, when implemented, will improve health, nutrition, and/or developmental outcomes for infants and young children. Projects can address the etiologic mechanisms of disease; new, improved, or less invasive diagnostic procedures; the reduction or elimination of side effects; the alleviation of symptoms; new, improved, or less invasive therapies or treatments; dosage or dosing requirements or mechanisms for drugs, nutrient supplementation, or other therapeutic measures (under or overdosing); and preventative measures.

The foundation awards grants for research focused on issues faced by care providers that, when implemented, will improve health, nutrition, and/or developmental outcomes for infants and young children. Projects can address the etiologic mechanisms of disease; new, improved, or less invasive diagnostic procedures; the reduction or elimination of side effects; the alleviation of symptoms; new, improved, or less invasive therapies or treatments; dosage or dosing requirements or mechanisms for drugs, nutrient supplementation, or other therapeutic measures (under or overdosing); and preventative measures.

In response to The Gabriella Miller Kids First Research Act ( https://www.congress.gov/bill/113th-congress/house-bill/2019/text), NIH, through the Common Fund, has established the Gabriella Miller Kids First Pediatric Research Program (Kids First). The Kids First program is expected to be a ten-year effort (2015 - 2024) that will build the Gabriella Miller Kids First Pediatric Data Resource (Kids First Data Resource). The Kids First Data Resource will be populated by genomic and phenotypic data and will be of high value to the pediatric research community by facilitating data mining across diverse conditions. During the first five years of this Program, data were generated and made publicly available following sequencing of DNA, and some RNA, samples from pediatric cancer and structural birth defects cohorts as outlined on the Kids First Common Fund website at https://commonfund.nih.gov/kidsfirst. In addition to increased understanding of individual pediatric conditions, a goal of establishing the Data Resource is to enable discovery of shared pathways whose disruption may lead to structural birth defects and/or susceptibility to childhood cancer. Therefore, representation of a wide variety of pediatric cancers and structural birth defects within the Data Resource is essential. The overall goal is to help researchers understand the underlying mechanisms of disease, leading to more refined diagnostic capabilities and ultimately more targeted therapies or interventions.

This Funding Opportunity Announcement (FOA) invites grant applications for research to examine 1) the impact of HAI on typical and atypical child development and health; 2) the evaluation of animal-assisted intervention for children and adults with disabilities or in need of rehabilitative services; 3) the effects of animals on public health, including cost effectiveness of involving animals in reducing and preventing disease.