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The purpose of this Funding Opportunity Announcement (FOA) is to support bi-phasic developmental, discovery-driven, or hypothesis-driven research focused on innovative strategies to detect HIV either within the first two weeks of infection or to monitor viral rebound after stopping or developing resistance to antiretroviral therapy. Applications should propose simple diagnostic tools that would be feasible for a self-testing platform to allow untrained individuals to detect HIV. Interdisciplinary collaborations that include biomedical, physical, and behavioral sciences are highly encouraged.

The NIDDK invites Cooperative Agreement applications for an open  competition for the Central Biochemistry Laboratory (CBL) of The Chronic Kidney Disease in Children (CKiD) consortium.  The CBL will work cooperatively with the existing Clinical Coordinating Centers (CCCs) and Data Coordinating Center (DCC) of the study as a Consortium. Participant evaluations in some domains will be expanded, and follow-up will extend beyond the onset of End Stage Renal Disease (ESRD).  

Background: The BLM routinely requires assistance to implement prescribed fire projects. These projects are utilized to reduce accumulations of hazardous fuels, improve wildlife habitat, and reduce the negative effects of wildfire. The BLM would like to continue to utilize a qualified recipient for prescribed fire projects on BLM managed lands. Due to time constraints and rules and regulations inherent to prescribed fire operations, the recipient must be red carded at the appropriate levels for the assigned projects, and should be a close, available resource. The goal is to develop a good working relationship and understanding of the roles and responsibilities required to implement and manage prescribed fire operations. Objectives: Select parcels of BLM, Montana lands have been identified as candidates for fuels reduction treatments. The objective is to effectively and efficiently treat these parcels in accordance with BLMs policy and standards and the National Fire Plan. Public Benefit: Reduce accumulations of natural and activity fuels on BLM managed lands across Montana as determined by the NEPA process. The projects will efficiently reduce the risk to the public and natural resources from wildland fire.

This FOA seeks applications for projects to design, construct, and operate large-scale pilots of transformational coal technologies aimed at enabling step change improvements in coal powered system performance, efficiency, and cost of electricity. The FOA will be carried out in three phases, with a down-select between phases. Phase I, Feasibility, will be aimed at supporting recipients' efforts to secure team commitments, including host sites and recipient cost share for Phase II, update the preliminary cost estimate and schedule for design, construction, and operation, and complete an environmental information volume. Projects selected for Phase II, Design, will complete a Front End Engineering Design study, secure construction-operation cost share funding, and complete the National Environmental Policy Act process. Finally, at least two projects will be selected for Phase III, Construction-Operation, which will support construction and operation of the large-scale pilot facilities. Any recipients proceeding to Phase III will be required to utilize domestic coal and/or domestic coal-derived fuels in the operation period. Applicants to Phase I who plan to primarily use other fuel sources during operations will be judged non-responsive. While only detailed Phase I applications are being solicited at this time, information relating to preliminary plans to carry out Phases II and III will be required to assess the potential viability of the overall project.

This Funding Opportunity Announcement (FOA) invites applications to establish Compound Identification Development Cores (CIDC) to develop innovative approaches to enhance compound identification of the most significant, biomedically-relevant unknown metabolites. The ultimate goal of this FOA is to expand the repertoire of biologically relevant compounds that can be quickly and inexpensively identified in high throughput metabolomics experiments. An interdisciplinary approach and partnership among metabolomics experts, biomedical researchers, chemists, and computational experts will be integral to the success of this goal, and advances made through this initiative are expected to be catalytic to the field.

his announcement explicitly encourages projects that improve the capacity of education systems and communities to create impactful STEM educational experiences for students and workers. Submissions are encouraged to consider including active learning approaches and incorporating 21st century skill development. Projects must aim to increase student and worker engagement in STEM and enhance people with needed Naval STEM capabilities. ONR encourages applications to utilize current STEM educational research for informing project design and advancing our understanding of how and why people choose STEM careers and opportunities of naval relevance. While this announcement is relevant for any stage of the STEM educational system, funding efforts will be targeted primarily toward projects addressing the below communities or any combination of these communities: * Secondary education communities; * Post-Secondary communities; * Informal science communities; * Current naval STEM workforce communities. Project scope may range in size and complexity. Projects that are already established with prior funding sources or have established stakeholders are especially encouraged to consider the following scope areas: * Develop and implement exploratory pilot projects that seek to create new educational experiences within educational and training communities. * Develop larger cohesive STEM education and training activities that strengthen the capacity of regional communities and stakeholders to improve STEM education and training.

The overarching goals of this program are to (i) prepare, nurture, and grow the national scientific research workforce for creating, utilizing, and supporting advanced cyberinfrastructure (CI) that enables potentially transformative fundamental science and engineering research and contributes to the Nation's overall economic competiveness and security; (ii) ensure broad adoption of CI tools, methods, and resources by the fundamental science and engineering research community to enable new modes of discovery; and (iii) integrate core literacy and discipline-appropriate advanced skills in advanced CI as well as computational and data science and engineering into the Nation's educational curriculum/instructional material fabric spanning undergraduate and graduate courses. For the purpose of this solicitation, advanced CI is broadly defined as the set of resources, tools, and services for advanced computation, data handling, networking, and security that collectively enable potentially transformative fundamental research.

The International Research Experiences for Students (IRES) program supports development of globally-engaged U.S. science and engineering students capable of performing in an international research environment at the forefront of science and engineering.  The IRES program supports active research participation by students enrolled as undergraduates or graduate students in any of the areas of research funded by the National Science Foundation.  IRES projects involve students in meaningful ways in ongoing research programs or in research projects specifically designed for the IRES program. 

Secretary of the Air Force Heather Wilson announced in September 2017 inception of the "S&T Strategy 2030" study. The study's objective is to update the Air Force methods for conducting research and development (R&D) to meet the projected national security challenges of 2030. Secretary Wilson appointed the Air Force Research Laboratory (AFRL) to lead this strategy development.The Air Force's goals for the study are: 1. Evaluate technical approaches and focus areas to advance the Air Force's mission through R&D; and 2. Improve Air Force processes and organizational structures to manage early stage research.

In this context, the Division of Chemistry is inviting requests for supplemental funding from its existing awardees who may wish to add a new, or strengthen an existing, international dimension of their award when such collaboration advances the field of chemistry and enhances the U.S. investigator's own research and/or education objectives. NSF's Proposal and Award Policies and Procedures Guide (PAPPG) Chapter VI.E.4, provides specific guidance on preparing a request for supplemental funding. Principal Investigators supported by NSF Division of Chemistry awards are advised to consult with their NSF program director prior to submitting a supplemental funding request. Supplemental funding requests should be submitted no later than April 2, 2018.

The Division of Molecular and Cellular Biosciences (MCB) has developed a new opportunity to enable researchers with a strong track record of prior accomplishment to pursue a new avenue of research or inquiry. This funding mechanism is designed to facilitate and promote a PI's ability to effective adopt empowering technologies that might not be readily accessible in the PI's current research environment or collaboration network. Transformative research likely spans disciplines and minimizing the practical barriers to doing so will strengthen research programs poised to make significant contributions. The award is intended to allow mid-career or later-stage researchers (Associate or Full Professor, or equivalent) to expand or make a transition in their research programs via a sabbatical leave or similar mechanism of professional development and then develop that research program in their own lab. This award will also enable the PI to acquire new scientific or technical expertise, facilitate the investigator's competitiveness, and potentially lead to transformational impacts in molecular and cellular bioscience.

The National Science Foundation (NSF), through its Divisions of Electrical, Communications and Cyber Systems (ECCS), Computing and Communication Foundations (CCF), Molecular and Cellular Biosciences (MCB), and Materials Research (DMR) announces a follow-up solicitation on the Semiconductor Synthetic Biology for Information Storage and Retrieval Program (SemiSynBio-II). Future ultra-low energy storage-based computing systems can be built on principles derived from organic systems that are at the intersection of physics, chemistry, biology, computer science and engineering. Next-generation information storage technologies can be envisioned that are driven by biological principles and use biomaterials in the fabrication of devices and systems that can store data for more than 100 years with storage capacity 1,000 times more than current storage technologies. Such a research effort can have a significant impact on the future of information storage and retrieval technologies. This focused solicitation seeks high-risk/high-return interdisciplinary research on novel concepts and enabling technologies that will address the fundamental scientific issues and technological challenges associated with the underpinnings of synthetic biology integrated with semiconductor technology. This research will foster interactions among various disciplines including biology, physics, chemistry, materials science, computer science and engineering that will enable in heretofore unanticipated breakthroughs.

With the NSF Convergence Accelerator, NSF's goals are: (i) to pilot a new NSF capability to accelerate use-inspired convergence research in areas of national importance, and (ii) to initiate convergence team-building capacity around exploratory, potentially high-risk proposals in specific convergence topics (tracks). The NSF Convergence Accelerator supports use-inspired, goal-oriented, basic research, encouraging rapid advances through partnerships that include multiple stakeholders (e.g., industry, academic, not-for-profits, government entities, and others). The NSF Convergence Accelerator brings teams together in a cohort that are all focused on a common research goal of national importance, but which may be pursuing many different approaches. As a funder of research and education across all fields of science and engineering and with relationships with universities and funding agencies around the world, NSF is uniquely positioned to pilot this approach to accelerate discovery and innovation. Teams supported by the NSF Convergence Accelerator will focus on grand challenges that require a convergence approach. The teams are multidisciplinary and leverage partnerships; tracks within the NSF Convergence Accelerator relate to a grand challenge problem and have a high probability of resulting in deliverables that will benefit society within a fixed term. The NSF Convergence Accelerator is modeled on acceleration and innovation activities from the most forward-looking companies and universities. Specific funding opportunities will be announced through Dear Colleague Letters, program announcements, and/or solicitations. For more information see the NSF Convergence Accelerator website: https://www.nsf.gov/od/oia/convergence-accelerator/index.jsp

The purpose of this Funding Opportunity Announcement (FOA) is to build upon the work that has begun under previous FOA RFA-TR-17-007 NCATS Pilot Program for Collaborative Drug Discovery Research Using Bioprinted Skin Tissue and utilize physiologically relevant and validated 3-D biofabricated skin disease tissue models in multi-well drug screening platforms. The FOA will support intramural- extramural collaborations to implement the use of 3-D biofabricated skin tissue models and provide evidence of success for 3-D drug screening platforms.

NineSigma, representing a major manufacturer, seeks a technology to identify compounds contributing to the odor. Especially, proposals from organizations that are eager to conduct sample testing for the client's odorous gases are anticipated.

The Science and Technology Centers (STC): Integrative Partnerships program supports exceptionally innovative, complex research and education projects that require large-scale, long-term awards. STCs focus on creating new scientific paradigms, establishing entirely new scientific disciplines and developing transformative technologies which have the potential for broad scientific or societal impact. STCs conduct world-class research through partnerships among institutions of higher education, national laboratories, industrial organizations, other public or private entities, and via international collaborations, as appropriate. They provide a means to undertake potentially groundbreaking investigations at the interfaces of disciplines and/or highly innovative approaches within disciplines. STCs may involve any area of science and engineering that NSF supports. STC investments support the NSF vision of creating and exploiting new concepts in science and engineering and providing global leadership in research and education.

To establish a rare disease consortium focusing on clinical outcome assessments appropriate for use in drug development to demonstrate clinical benefit.    

To that end, grants of up to $5 million will be awarded in support of research on innovative pharmacologic interventions for Alzheimer's disease and related dementias, including clinical trials, regulatory studies for novel drugs (small molecules and biologics, including antibodies, peptides, gene therapies), repurposed drugs (existing drugs that are approved for other diseases and conditions), repositioned drugs (existing drugs that have entered clinical trials for other indications and have not yet been approved), and natural products.