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The ARP Clinical Translational Research Award is intended to support early-phase, proof-of-principle translational studies that will examine hypothesis-based, innovative interventions that have the potential to address current clinical deficits for ASD. Applications are strongly encouraged to address one of the ARP Clinical Translational Research Award Areas of Interest. If the proposed project does not address any of the FY19 ARP Clinical Translational Research Award Areas of Interest, the application should describe how the project will nevertheless address a critical need of the ASD community. Outcomes from studies funded by this award are anticipated to provide scientific rationale for subsequent development of larger, efficacy-based clinical trials of interventions that will transform ASD clinical care. Projects are required to involve human subjects. Projects that are strictly animal research aimed at developing or refining new technology and research to establish the efficacy/ effectiveness of diagnostic agents are not allowed under this funding opportunity. The proposed studies should include early-phase, proof-of-principle studies using human subjects. The proposed studies may be interventional, including Phase 0 clinical trials or single-group intervention studies, and may involve some retrospective data analysis; however, purely retrospective or database-related research is not allowed.

The ARP Idea Development Award supports the development of innovative, high-risk/high-reward research that could lead to critical discoveries or major advancements that will accelerate progress in improving outcomes for individuals with ASD. This award mechanism is designed to support innovative ideas with the potential to yield impactful data and new avenues of investigation.

The overall goal of the NIH Research Career Development program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's biomedical, behavioral, and clinical research needs. NIH Institutes and Centers (ICs) support a variety of mentored and non-mentored career development award programs designed to foster the transition of new investigators to research independence and to support established investigators in achieving specific objectives. Candidates should review the different career development (K) award programs to determine the best program to support their goals. More information about Career programs may be found at the NIH Extramural Training Mechanisms website. The objective of the Career Enhancement Award for Experienced Investigators (K18) is to provide support for experienced scientists who either wish to broaden their scientific capabilities or to make changes in their research careers by acquiring new research skills or knowledge. The purpose of this FOA is to provide such investigators with support for an intensive period of mentored research experience to acquire new research capabilities in research areas supported by the sponsoring NIH Institute(s)/Center(s). Such experiences will afford candidate investigators protected time to: 1) enrich and expand their expertise and research programs through retooling in new techniques, emerging technologies, and/or scientific areas; and/or 2) redirect their research programs in new trajectories; and/or 3) catalyze research collaborations in new research directions.  It is expected that this initiative will lead to new and/or augmented research programs competitive for NIH funding.