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This Funding Opportunity Announcement (FOA) solicits Small Business Innovative Research (SBIR) grant applications from small business concerns (SBCs) to develop novel technologies to expand the capability for molecular analyses of banked frozen or formalin-fixed, paraffin-embedded tissues. There is a need for improved tissue preservation methods that maintain histologic features while preserving high quality DNA, RNA, protein and small molecules in archived tissue from rodent and human studies. In addition, novel approaches are needed to preserve DNA, RNA, and small molecules during collection and storage of biological samples.

This Funding Opportunity Announcement (FOA) solicits Small Business Innovative Research (SBIR) grant applications from small business concerns (SBCs) to develop novel technologies to expand the capability for molecular analyses of banked frozen or formalin-fixed, paraffin-embedded tissues. There is a need for improved tissue preservation methods that maintain histologic features while preserving high quality DNA, RNA, protein and small molecules in archived tissue from rodent and human studies. In addition, novel approaches are needed to preserve DNA, RNA, and small molecules during collection and storage of biological samples.

This Funding Opportunity Announcement (FOA) solicits Small Business Innovative Research (SBIR) grant applications from small business concerns (SBCs) to develop novel technologies to expand the capability for molecular analyses of banked frozen or formalin-fixed, paraffin-embedded tissues. There is a need for improved tissue preservation methods that maintain histologic features while preserving high quality DNA, RNA, protein and small molecules in archived tissue from rodent and human studies. In addition, novel approaches are needed to preserve DNA, RNA, and small molecules during collection and storage of biological samples.  

The purpose of this RFA is to encourage studies on reproductive health, fertility and fertility preservation/treatment options in patients born with a serious chronic condition who can now expect to survive into adulthood healthy enough to consider their reproductive health and fertility options. The underlying pathophysiology of diseases such as sickle cell anemia, thalassemia, and cystic fibrosis, among others, and/or the cumulative effects of their treatment, can compromise reproductive health. This RFA encourages teams of scientists with expertise in the realm of the particular disease and in reproductive health and fertility to work together to understand the effects of the diseases and/or their treatments on parameters of reproductive health, and to identify ways to preserve, protect, or treat and reproductive deficits in these patients.

This Funding Opportunity Announcement (FOA) solicits Small Business Innovative Research (SBIR) grant applications from small business concerns (SBCs) to develop novel technologies to expand the capability for molecular analyses of banked frozen or formalin-fixed, paraffin-embedded tissues. In addition, there is a need for improved tissue fixatives and preservation methods that maintain histologic features while preserving high quality DNA, RNA, protein and small molecules in archived tissue from rodent and human studies.

Collections in Support of Biological Research (CSBR) provides for enhancements that secure and improve existing research collections, improve the accessibility of collection-related data, develop capacity for curation and collection management, and to transfer ownership of collections that are significant to the NSF BIO-funded research community. Requests should demonstrate a clear and urgent need to secure or improve the collection, and the proposed activities should address that need. Types of biological collections that are supported include established living stock/culture collections, established natural history voucher collections, and jointly-curated ancillary collections such as preserved tissues and libraries of genetic and genomic materials. Biological research collections support essential research activities in the biological sciences. Collections are used to document biodiversity, identify species, understand organismal systems, recognize environmental shifts, explore alternate energy sources, understand evolutionary patterns, and improve agricultural, biomedical, and manufacturing applications. Natural history collections contain records of life on earth that are unique and irreplaceable, including specimens of extinct species and temporal information on changes in the ranges of native and introduced species. Many collections also house voucher-linked ancillary research materials (including DNA and frozen tissue samples, digital images, audio and video files). Living collections play a key role in the advancement and preservation of biological knowledge by providing well-characterized and documented experimental organisms to researchers at modest cost.

The U.S. Embassy Vientiane Public Diplomacy Section announces an open competition for organizations to submit project proposals for funding under the U.S. Embassy's 2018 Public Diplomacy Small Grants Program. This Notice of Funding Opportunity (NOFO) solicits proposals for projects that further the U.S. Mission's public diplomacy goals of strengthening people-to-people ties between Laos and the United States, expanding educational opportunities for Lao people to better engage with the United States and ASEAN, and building and strengthening local partners through the specific objectives listed below. Proposals for projects must focus on one of the priority areas specified below. Applicants should pay close attention to the Public Diplomacy Section's goals, priority program objectives, and target audiences when developing their proposals. Funding Opportunities include: Public Diplomacy Goals Education Inclusiveness and support issues related to: women, disabled persons, LGBT rights, ethnic minorities, other marginalized and stigmatized groups such as victims of human trafficking, underprivileged youth, or religious minorities. Promoting fundamental American values: promoting freedom of expression, press, association, and religion through public dialogue and events, cultural performances, the arts. Rule of Law Health and wellness Youth Women's empowerment Alumni Volunteering Entrepreneurship Environment Cultural Preservation

Scan high definition digital images of BLM and CESU partner herbarium specimens, collected and preserved over the last several decades, and then make available to anyone via the Rocky Mountain Herbarium online database.

The CSBR program provides for enhancements that secure and improve existing collections, result in accessible digitized specimen-related data, and develop better methods for specimen curation and collection management. Requests should demonstrate a clear and urgent need to secure the collection, and the proposed activities should address that need. Biological collections supported include established living stock/culture collections, vouchered non-living natural history collections, and jointly-curated ancillary collections such as preserved tissues and DNA libraries.

The Office of Research Infrastructure Programs (ORIP) supports research-related resources that create, develop, preserve and supply a variety of high-quality animal models, and related biological materials. ORIP also supports the development and implementation of tools and devices that directly benefit the welfare of research animals, improve handling of laboratory animals, and ease the management of animal facilities. This Funding Opportunity Announcement (FOA) encourages small business concerns to submit Small Business Technology Transfer (STTR) grant applications that propose innovative approaches and technologies to further develop, improve and facilitate the use of animal models and related biological materials, to meet new biomedical challenges related to improvements in the health of humans and the welfare of animal models.

This Funding Opportunity Announcement (FOA) solicits grant applications proposing exploratory research projects focused on the early-stage development of highly innovative technologies that improve the quality of the samples used for cancer research or clinical care. This includes new capabilities to address issues related to pre-analytical degradation of targeted analytes during the collection, processing, handling, and/or storage of cancer-relevant biospecimens. The overall goal is to support the development of highly innovative technologies capable of maximizing or otherwise interrogating the quality and utility of biological samples used for downstream analyses. This FOA will support the development of tools, devices, instrumentation, and associated methods to preserve or protect sample integrity, or establish verification criteria for quality assessment/quality control and handling under diverse conditions. These technologies are expected to accelerate and/or enhance research in cancer biology, early detection and screening, clinical diagnosis, treatment, epidemiology, or address issues associated with cancer health disparities, by reducing pre-analytical variations that affect biospecimen sample quality.

The National Toxicology Program (NTP) was established within the Department of Health and Human Services and charged with coordinating toxicological testing programs within the Public Health Service of the Department. The NTP, as part of the National Institute of Environmental Health Sciences (NIEHS), is responsible for evaluating the toxic and carcinogenic potential of environmental agents that may pose a health hazard to citizens of the United States. The NTP requires support for the conduct of short- and long-term toxicity and carcinogenicity studies following exposure to a variety of test agents by various routes of exposure. This requirement is designed to study diverse agents that may include: environmental chemicals; chemicals used in manufacturing or industrial settings; naturally occurring chemicals; food additives, preservatives, colorants or flavorings; pharmaceuticals, botanically- and non botanically-based dietary supplements; herbicides, fungicides, and pesticides; ingredients found in a wide variety of consumer products including soaps, lotions, perfumes and cosmetics; chemicals used in detergents and cleaners, etc.; naturally occurring and synthetic fibers, nanomaterials including carbon nanotubes; metals; plasticizers; flame retardants; mold or mold components; or other agents not specified at this time.

The Program is pleased to announce that it is seeking proposals for funding to support forensic and biometric research and its application. The requested proposals should focus on DFBA activities and needs of the Program's other customers (AFMES, DC3, JPAC-CIL). Forensic research proposals should focus on the creation of new and improved field or laboratory functional capabilities that result in faster, more robust, more informative, less costly, or less labor-intensive recognition, identification, collection, preservation, and/or analysis of forensic evidence. Biometric research proposals should contribute to biometric applications or operations, including military functions such as combat identification (friend, foe, or neutral), offensive operations (intelligence support to targeting), force protection (physical access control), detention operations, civil-military operations (track target members of a population), personnel recovery and identification, and recognition and recovery of human remains. Proposals that will assist the DoD in achieving these goals are solicited, particularly proposals involving the development of equipment that is portable, sustainable, and useful in an expeditionary or field environment. The expeditionary and field environments require systems that are lightweight, portable, inexpensive, fast, and capable of operating in extreme environments of temperature, dust, humidity, etc. The systems must also be capable of secure data communications.

Prevent Blindness Ohio is accepting applications for its 2014 Young Investigator Student Fellowship Awards for Female Scholars in Vision Research. The Fellowship Program is designed to provide support for outstanding female scientists committed to pursuing biomedical, behavioral or clinical research careers relevant to the mission of Prevent Blindness Ohio - to prevent blindness and preserve sight. 

The Glaucoma Foundation works to encourage and support basic and applied research in glaucoma,  gain and disseminate new information about the causes and treatment of glaucoma, and  further efforts to identify and develop novel approaches to preserve visual function and reverse blindness caused by glaucoma.

This Funding Opportunity Announcement (FOA) solicits grant applications proposing technically innovative feasibility studies focused on early-stage development of technologies that address issues related to pre-analytical variations in the collection, processing, handling, and storage of cancer-relevant biospecimens or their derivatives. The overall goal is to develop technologies capable of interrogating and/or maximizing the quality and utility of biospecimens or samples derived from those biospecimens for downstream analyses. This FOA will support the development of tools, devices, instrumentation, and associated methods to assess sample quality, preserve/protect sample integrity, and establish verification criteria for quality assessment/quality control and handling under diverse conditions. These technologies are expected to potentially accelerate and/or enhance research in cancer biology, early detection, screening, clinical diagnosis, treatment, epidemiology, and cancer health disparities, by reducing pre-analytical variations that affect biospecimen sample quality. All projects must include quantitative milestones (i.e., technical metrics that determine whether the specific aims have been accomplished). This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program.

This Funding Opportunity Announcement (FOA) solicits grant applications proposing technically innovative feasibility studies focused on the advanced development and validation of cancer-relevant technologies that address issues related to pre-analytical variations in the collection, processing, handling, and storage of biospecimens or their derivatives. The overall goal is to develop technologies capable of interrogating and/or maximizing the quality and utility of biospecimens or their derived samples for downstream analyses. This FOA will support the development of tools, devices, instrumentation, and associated methods to assess sample quality, preserve/protect sample integrity, and establish verification criteria for quality assessment/quality control and handling under diverse conditions. This FOA solicits R33 applications for projects where proof-of-principle of the proposed technology or methodology has already been established and supportive preliminary data are available. Projects proposing to use established technologies where the novelty resides in the biological or clinical question being pursued are an example of a topic not appropriate for this solicitation and will not be reviewed.

There is a need to develop technologies that support research using zebrafish models of biomedical value. The zebrafish has become increasingly important as a biological resource, because of its small size, short generation time, easy manipulation of embryos and optical transparency. This animal model is used to study aspects of gene structure and function that can be directly related to human genetics and disease. Zebrafish are also important for studies in diverse disciplines, including pharmacology, toxicology, neurobiology, behavior and developmental biology. This funding opportunity announcement (FOA) encourages applications from small business concerns (SBCs) for Small Business Innovation Research (SBIR) projects that propose innovative research and development of technology, including reagents and high throughput equipment, to support different aspects of the creation, detection, identification and characterization of zebrafish models of human disease and preservation of genetic stocks.

Biological Field Stations and Marine Laboratories (FSMLs) are off-campus facilities for research and education conducted in the natural habitats of terrestrial, freshwater, and marine ecosystems. FSMLs support environmental and basic biological research and education by preserving access to study areas and organisms, by providing facilities and equipment in close proximity to those study areas, and by fostering an atmosphere of mutual scientific interest and collaboration in research and education. To fulfill these roles, FSMLs must offer modern research and educational facilities, equipment, communications and data management systems for a broad array of users. In recognition of the importance of FSMLs in modern biology, NSF invites proposals that address these general goals of FSML improvement.

Biological Field Stations and Marine Laboratories (FSMLs) are off-campus facilities for research and education conducted in the natural habitats of terrestrial, freshwater, and marine ecosystems. FSMLs support environmental and basic biological research and education by preserving access to study areas and organisms, by providing facilities and equipment in close proximity to those study areas, and by fostering an atmosphere of mutual scientific interest and collaboration in research and education.

Biological Field Stations and Marine Laboratories (FSMLs) are off-campus facilities for research and education conducted in the natural habitats of terrestrial, freshwater, and marine ecosystems. FSMLs support environmental and basic biological research and education by preserving access to study areas and organisms, by providing facilities and equipment in close proximity to those study areas, and by fostering an atmosphere of mutual scientific interest and collaboration in research and education.