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The Division of Mathematical Sciences (DMS) in the Directorate for Mathematical and Physical Sciences (MPS) at the National Science Foundation (NSF) and the National Library of Medicine (NLM)at the National Institutes of Health (NIH)plan to support the development of innovative and transformative mathematical and statistical approaches to address important data-driven biomedical and health challenges. The rationale for this interagency collaboration is that significant advances may be expected as the result of continued NSF investments in foundational research in mathematics and statistics as well as inter- and multi-disciplinary research and training at the intersection of the quantitative/computational sciences and domain sciences, while NIH benefits from the enhancement of biomedical data science with new approaches that strengthen the reproducibility of biomedical research and support open science.