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The Dynamics of Coupled Natural and Human Systems (CNH) Program supports interdisciplinary research that examineshuman and natural system processes and the complex interactions among human and natural systems at diverse scales. Research projects to be supported by CNH must include analyses of four different components: (1) the dynamics of a natural system; (2) the dynamics of a human system; (3) the processes through which the natural system affects the human system; and (4) the processes through which the human system affects the natural system. CNH also supports research coordination networks (CNH-RCNs) designed to facilitate activities that promote future research by broad research communities that will include all four components necessary for CNH funding.

The goal of this FOA is to establish functional genotype-phenotype relationships of genetic variants, suspected of altering the risk of Alzheimer's disease (AD), in neural cells using human induced pluripotent stem cells or other human cell reprogramming approaches. The causal linkage of AD-associated genetic variants identified in genome-wide association studies and genome sequencing studies to molecular and biological cell phenotypes in human neural cells is expected to give greater insight into molecular targets contributing to the etiology of AD. Studies of human genetics in human cells are essential to understanding the etiology of AD.

This funding opportunity announcement (FOA) supports the development of PET radioligands that identify proteinopathies or pathological processes associated with the human biology of Alzheimer's disease related dementias (ADRDs). Activities supported under this FOA include, but are not limited to the in vitro screening of existing ligands against human ADRD brain tissue, medicinal chemistry support for development of new compounds and improvement of existing ligand specificity and selectivity, initial screening of ligands in appropriate animal models, and radioligand formulation and first-in-human testing. The Center without Walls should encompass research that will move promising ligands through in vitro and in vivo optimization to first-in-human studies. Applications must include an administrative core, a medicinal chemistry core, a clinical core, a scientific governance structure, and a minimum of two research projects with milestone plans that address workflows for screening of existing and newly derived ligands against human ADRD tissue and appropriate animal models. Synergy must be evident among Center research projects and cores, such that successful completion of the aims could not be accomplished without the Center structure. This FOA is in response to the Alzheimer's Disease Related Dementias (ADRD) challenges outlined in the 2016 update to the National Plan to Address Alzheimer's Disease.

The overall objective of the LungMAP is to better understand human lung development by building an open-access reference resource of a comprehensive, dynamic, 3-D molecular atlas of the late-stage developing human lung with data and reagents available to the research community. Phase 1 of the LungMAP has generated foundational data from developing mouse and human lungs, created a web portal for public data sharing, and established a repository of human lung tissues. Phase 2 of the LungMAP will continue to generate and integrate high-resolution, multiscale molecular profiles associated with spatial information to provide molecular characterizations of functionally and anatomically defined cell types in the developing human lung.

The purpose of this FOA is to stimulate development of translation-enabling models for evaluating survival and integration of regenerated photoreceptors (PRCs) and retinal ganglion cells (RGCs) in model systems that are closer to human visual anatomy, function and/or disease than current models. The development of these models, tools, devices, novel therapies and/or other resources is expected to provide a resource to vision researchers developing cell-replacement therapies for visual system diseases and disorders. This FOA seeks to develop models that emulate critical aspects of a human blinding disease that might be amenable to regenerative therapy. The model system might involve specific defects generated by transgenic gene insertion and/or deletion, gene editing, chemical/physical means, and/or other approaches to emulate characteristics of human disease or create defects amenable to cell-replacement therapy. Model systems using non-human primates or other cone-dominant species that are more representative of the anatomy and physiology of the human retina are highly encouraged. Other biological models are acceptable provided they meet the overall objectives of the FOA.

The HFC program seeks proposals for research to develop and test hybrid geopolitical forecasting systems. These systems will integrate human and machine forecasting components to create maximally accurate, flexible, and scalable forecasting capabilities. Human-generated forecasts may be subject to cognitive biases and/or scalability limits. Machine-generated (i.e., statistical, computational) forecasting approaches may be more scalable and data-driven, but are often ill-suited to render forecasts for idiosyncratic or newly emerging geopolitical issues. Hybrid approaches hold promise for combining the strengths of these two approaches while mitigating their individual weaknesses. Performers will develop systems that will integrate human and machine forecasting contributions in novel ways. These systems will compete in a multi-year competition to identify approaches that may enable the Intelligence Community (IC) to radically improve the accuracy and timeliness of geopolitical forecasts.

The HFC program seeks proposals for research to develop and test hybrid geopolitical forecasting systems. These systems will integrate human and machine forecasting components to create maximally accurate, flexible, and scalable forecasting capabilities. Human-generated forecasts may be subject to cognitive biases and/or scalability limits. Machine-generated (i.e., statistical, computational) forecasting approaches may be more scalable and data-driven, but are often ill-suited to render forecasts for idiosyncratic or newly emerging geopolitical issues. Hybrid approaches hold promise for combining the strengths of these two approaches while mitigating their individual weaknesses. Performers will develop systems that will integrate human and machine forecasting contributions in novel ways. These systems will compete in a multi-year competition to identify approaches that may enable the Intelligence Community (IC) to radically improve the accuracy and timeliness of geopolitical forecasts.

The purpose of the NIH Independent Scientist Award (K02) is to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research. The K02 award provides three to five years of salary support and "protected time" for newly independent scientists who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. Each independent scientist career award program must be tailored to meet the individual needs of the candidate. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to lead basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the companion PA-18-370.

The primary purpose of the NIH Mentored Clinical Scientist Research Career Development Awards (K08) program is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. This program represents the continuation of a long-standing NIH program that provides support and "protected time" to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to lead basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the companion PA-18-372.

The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of individuals with a clinical doctoral degree who have made a commitment to focus their research endeavors on patient-oriented research. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to lead basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the companion PA-18-375.

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Funding Opportunity Announcement is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the appropriate Clinical Trials Required or Clinical Trial Optional FOA. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

The purpose of the NIH Pathway to Independence Award (K99/R00) program is to increase and maintain a strong cohort of new and talented, NIH-supported, independent investigators. This program is designed to facilitate a timely transition of outstanding postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition in order to help awardees to launch competitive, independent research careers. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to lead basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the companion PA-18-397.

The purpose of the NIH Midcareer Investigator Award in Patient-Oriented Research (K24) is to provide support to mid-career health-professional doctorates for protected time to devote to patient-oriented research (POR) and to act as research mentors primarily for clinical residents, clinical fellows and/or junior clinical faculty. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to lead basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the companion PA-18-393.

The Michelson Medical Research Foundation (MMRF) together with the Human Vaccines Project have established the Michelson Prizes for Human Immunology and Vaccine Research. The $20 million initiative, funded by the MMRF and administered by the Human Vaccines Project, aims to support young investigators applying innovative research concepts and disruptive technologies to significantly advance the development of future vaccines and therapies to defeat major global diseases. While the Michelson Prizes are focused on research outcomes in the fields of human immunology and vaccinology, applicants from the full spectrum of related disciplines, including clinical research, biomedicine, artificial intelligence/machine learning, engineering, and nanotechnology are encouraged to apply. Proposals will be reviewed and winners selected by a distinguished committee of internationally-recognized research scientists.

This interagency Funding Opportunity Announcement (FOA) issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Food and Agriculture (USDA-NIFA) is to invite the submission of grant applications that utilize agriculturally important domestic animal species to improve human health through the advancement of basic and translational research deemed highly relevant to both agricultural and biomedical research. This initiative is designed to facilitate and encourage comparative medicine research studies through the careful selection and refinement of farm animal models that mimic human developmental, physiological and etiological processes to better understand disease origins and improve assisted reproduction efficiencies. The anticipated outcomes include both the elucidation of fundamental information relevant for the improvement of human health and an increase in food animal production and improvement in animal health and product quality. It is envisioned that each application will address mission-relevant areas of both agencies.

Researchers from across the country are invited to apply for awards for grant proposals on soy and human health for eventual submission to NIH. Incentive awards of up to $25,000 will be awarded Incentive Awards are awarded to researchers who develop the best research concepts on soy and human health. In addition to welcoming proposals dealing with soy protein, isoflavones, etc., funds have been earmarked for at least two proposals dealing with soybean oil and human health. Applications on any aspect of soy and human health will be accepted

Miami faculty should notify Associate Provost Jim Oris of their interest in the following RFP. ---------- CGS invites doctoral-granting member institutions to apply to participate in Understanding PhD Career Pathways for Program Improvement, a multi-institution effort to collect and use data on PhD career pathways, funded by The Andrew W. Mellon Foundation and the National Science Foundation (NSF #1661272). This is an important opportunity to deepen your institution's understanding of the career goals and outcomes of its PhDs; communicate your support for the career diversity of PhDs; make evidence-based interventions that support the success of PhDs and the recruitment of future students; and access anonymized benchmarking data compiled from other project partners.   Awards: Option 1: Humanities Only. Provides awards of $30,000 each to support implementation of surveys of humanities PhD students and alumni over a period of twenty-four months. Supported by the Andrew W. Mellon Foundation; 15 awards available. Please indicate in your proposal why a humanities-only project aligns with your institutional mission.   Option 2: STEM Only. Provides awards of $50,000 to each to support implementation of surveys of STEM PhD students and alumni over a period of thirty-six months. Supported by the National Science Foundation; 15 awards available. Please indicate in your proposal why a STEM-only project aligns with your institutional mission.   Option 3: Combined Proposal. If an institution meets the eligibility requirements for both the Humanities and STEM awards, CGS strongly encourages the submission of a combined proposal. Institutions selected to participate in this category will receive a total award amount of $80,000.

The Syngenta Fellowship Award in Human Health Applications of New Technologies is presented to either a third year (or later) graduate student or a postdoctoral trainee. Fellowship funding is to support mode-of-action research aimed at characterizing dose-dependent effects of xenobiotics on mammalian systems in such a way that the causal sequence of key events underlying toxicity is elucidated. The work should permit a quantitative basis for extrapolation of the results from animal bioassays or animal models (in silico, in vitro) to humans at relevant human doses. The awardee will receive travel support to travel to the SOT Annual Meeting to accept the award and for travel to a Syngenta facility to present the results. This is a one year, non-renewable award.

The purpose of this funding opportunity announcement (FOA) is to support projects that will generate reference profiles of both short and long non-coding regulatory extracellular RNAs (exRNA), including any environmentally-derived exRNA (e.g. from diet, microbiome), from a diversity of healthy human body fluids including blood, saliva, urine, breast milk, semen, amniotic fluid, cerebrospinal fluid, ascites and pleural effusions. Studies using existing human biospecimen collections are strongly encouraged. This FOA is only for studies related to human samples; animal or other non-human disease model studies are not responsive to this FOA.

The Human Cell Atlas (HCA) is a global effort to create a reference map of all cell types in the human body. It is an ambitious goal to generate a fundamental reference for biomedical research. The HCA was born out of advances in single cell biology that made it conceivable to collect extensive measurements that inform our understanding of cellular heterogeneity in health and disease. Due to the growth of the community, pace of technology, and interest from the international community, the project has gone from conceivable to feasible. The Chan Zuckerberg Initiative and the Helmsley Charitable Trust are pleased to announce continued support for the Human Cell Atlas by collaborating on two new funding mechanisms that the community can access through a single application portal. The Chan Zuckerberg Initiative seeks to continue the work of the HCA community with a focus on interdisciplinary work and collaboration through the formation of 3 year Seed Networks. The Helmsley Charitable Trust welcomes applications that will construct a detailed atlas of the human gut. CZI Seed Networks aim to solidify growth of the community and result in a first draft of several organs - there is no requirement for a gut component in CZI applications. Additionally, newly formed Networks are designed to catalyze partnership among the scientific community and the funding community so that we can work together toward a first draft of the HCA.

The Biological Anthropology Program supports multifaceted research to advance scientific knowledge of human biology and ecology, including understanding of our evolutionary history and mechanisms that have shaped human and nonhuman primate biological diversity. Supported research focuses on living and fossil forms of both human and nonhuman primates, addressing time scales ranging from the short-term to evolutionary, encompassing multiple levels of analysis (e.g., molecular, organismal, population, ecosystem), conducted in field, laboratory, captive, and computationalresearch environments, and often incorporating interactions between human biology and culture.

Areas of inquiry that promote understanding of the evolution, biology, and adaptability of our diverse species include, but are not limited to:genetic/epigenetic/genomic variation and relationship to phenotype;ecology and socioecology; functional anatomy and skeletal biology; andpaleoanthropology and primate paleontology. Multidisciplinary research that integrates biological anthropology with related anthropological fields, such as archaeology, cultural anthropology, and forensic anthropology, also may receive support through the Program. The Program contributes to the integration of education and basic research through support of dissertation projects conducted by doctoral students enrolled in U.S. universities. This solicitation specifically addresses the preparation and evaluation of proposals for such Doctoral Dissertation Research Improvement (DDRI) Grants. Dissertation research projects in all of the subareas of biological anthropology are eligible for support through these grants. These awards are intended to enhance and improve the conduct of dissertation research by doctoral students who are pursuing research in biological anthropology that enhances basic scientific knowledge.