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MiamiOH OARS

Cognition Biomarkers RFA 2013 | The Michael J. Fox Foundation - 0 views

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    This program will support projects to develop cognition biomarkers or combinations of biomarkers that help to identify the transitions between normal cognition and cognitive impairment, and between cognitive impairment and dementia.
MiamiOH OARS

PAR-16-448: Basic and Translational Research on Decision Making in Aging and Alzheimer'... - 0 views

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    This funding opportunity announcement (FOA) invites applications for basic research to better characterize the affective, cognitive, social, and motivational parameters of impaired and intact decision making in both normal aging and Alzheimer's disease (AD). Research is sought that will characterize the extent to which basic behavioral and neural processes involved in decision-making are differentially impacted in normal aging and AD, investigate the influence of social factors on decision-making, and investigate the decision-making factors that render older adults (with or without cognitive impairment) vulnerable to financial exploitation and other forms of mistreatment and abuse. The FOA also invites applications to apply basic research on the processes involved in decision-making to the design of decision-supportive interventions for midlife and older adults with and without AD. Specific opportunities include the development of decision-supportive interventions to leverage cognitive, emotional and motivational strengths of these populations; tools to assess decisional capacity; strategies for simplifying choices and offering better defaults; and the promotion of timely adoption of optimal delegation practices (e.g., power of attorney, living wells, etc.).
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    This funding opportunity announcement (FOA) invites applications for basic research to better characterize the affective, cognitive, social, and motivational parameters of impaired and intact decision making in both normal aging and Alzheimer's disease (AD). Research is sought that will characterize the extent to which basic behavioral and neural processes involved in decision-making are differentially impacted in normal aging and AD, investigate the influence of social factors on decision-making, and investigate the decision-making factors that render older adults (with or without cognitive impairment) vulnerable to financial exploitation and other forms of mistreatment and abuse. The FOA also invites applications to apply basic research on the processes involved in decision-making to the design of decision-supportive interventions for midlife and older adults with and without AD. Specific opportunities include the development of decision-supportive interventions to leverage cognitive, emotional and motivational strengths of these populations; tools to assess decisional capacity; strategies for simplifying choices and offering better defaults; and the promotion of timely adoption of optimal delegation practices (e.g., power of attorney, living wells, etc.).
MiamiOH OARS

Understanding and Modifying Temporal Dynamics of Coordinated Neural Activity (R01) - 0 views

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    This funding opportunity supports projects that test whether modifying electrophysiological patterns during behavior can improve cognitive, affective, or social processing. Applications must use experimental designs that incorporate active manipulations to address at least one, and ideally more, of the following topics: (1) in animals or humans, determine which parameters of neural coordination, when manipulated in isolation, improve particular aspects of cognitive, affective, or social processing; (2) in animals or humans, determine how particular abnormalities at the genomic, molecular, or cellular levels affect the systems-level coordination of electrophysiological patterns during behavior; (3) determine whether in vivo, systems-level electrophysiological changes in behaving animals predict analogous electrophysiological and cognitive improvements in healthy persons or clinical populations; and (4) use biologically-realistic computational models that include systems-level aspects to understand the function and mechanisms by which oscillatory and other electrophysiological patterns unfold across the brain to impact cognitive, affective, or social processing.
MiamiOH OARS

Prevention Beyond the Pipeline | Alzheimer's Drug Discovery Foundation - 0 views

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    The ADDF seeks to support comparative effectiveness research, prevention clinical trials, and epidemiological studies that probe whether the use or choice of drugs alters the risk for dementia or cognitive decline. Specifically, the Prevention Beyond the Pipeline RFP supports: * Studies Leveraging the Consortium of Cohorts for Alzheimer's Prevention Action (CAPA) * Comparative Effectiveness Research: Methods may include randomized trials or epidemiology. * Studies of Cognitive Decline and Cognitive Reserve: Methods may include epidemiology or clinical trials. Current target areas of interest include: - Epigenetics - Inflammation - Mitochondria & metabolic function - Neuroprotection - Proteostasis - Synaptic activity and neurotransmitters - Vascular function - Other aging targets (e.g. senescent cells) - Other novel targets or pathways that are supported by compelling evidence demonstrating a rational biological connection to age-related cognitive decline or dementia risk   
MiamiOH OARS

Small Vessel Vascular Contributions to Cognitive Impairment and Dementia (VCID) Biomark... - 0 views

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    In May of 2013 the National Institute of Neurological Disorders and Stroke (NINDS), with input from the National Institute on Aging (NIA), held an Alzheimer's Disease-Related Dementias Conference in response to the National Plan to Address Alzheimer's Disease. The Conference brought together national and international experts and members of the public to develop research priorities for accelerating the development of therapies for the Alzheimer's disease-related dementias (ADRDs). The ADRD 2013 research recommendations that resulted are part of the National Plan to Address Alzheimer's Disease. This FOA addresses the National Plan's highest priority for human-based research on vascular contributions to cognitive impairment and dementia (VCID): to develop noninvasive markers of key vascular processes related to VCID in Alzheimer's and related dementias. The research program initiated here underscores the need to facilitate the development of biomarkers to improve the efficiency and outcome of Phase II and III clinical trials and advance therapeutic development. These companion FOAs (RFA-NS-16-019, i.e. this FOA; and RFA-NS-16-020 for the Biomarkers Development Projects) establish the Small Vessel VCID Biomarkers Consortium, and are focused on small vessel (i.e. arterioles, capillaries, and venules) VCID in vascular cognitive impairment (VCI), vascular dementia, and all mixed and pure cognitive impairment and dementias with contributing small vessel vascular disease, including such as commonly occurs in sporadic Alzheimer's disease. Awards funded under these two FOAs create a consortium and infrastructure to complete development projects as well as planning that will enable follow-up activities (to be carried out under future separate funding; for example large scale multi-site validation studies and other activities, for future FDA qualification of small vessel VCID biomarkers and use in clinical trials).
MiamiOH OARS

Characterization of Circulating Pro- and Anti-Geronic Proteins and Peptides - 0 views

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    The goal of this FOA is to advance research on the underlying basis for the transfer (or transposition) of aging phenotypes observed between young and old rodents and discovered through heterochronic parabiosis. Examples of transposed phenotypes include reversal of cardiac hypertrophy, partial restoration of cognitive function, improved vascularization, and repair of skeletal muscle after cryo-injury (anti-geronic transposition), or as accelerated loss of cognitive function and neurogenesis (pro-geronic transposition). Other transposed phenotypes, as revealed solely through heterochronic parabiosis, may also be reported in the literature. There are also reports of candidate factors found in circulation that might be causally related to the transposition of these aging phenotypes; these are termed "circulating geronic factors" for purposes of this FOA. To date, these are proteins and peptides that pass between the young and old mice joined by parabiosis, due to anastomosis of their circulatory systems. Based on these novel findings and this novel experimental paradigm, the specific objective of this FOA is to test whether these candidate geronic factors are necessary for the transposition of aging phenotypes. The focus is on phenotypes transposed in heterochronic parabiosis and the candidate factors which are present and functional at physiological concentrations in circulation.
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    The goal of this FOA is to advance research on the underlying basis for the transfer (or transposition) of aging phenotypes observed between young and old rodents and discovered through heterochronic parabiosis. Examples of transposed phenotypes include reversal of cardiac hypertrophy, partial restoration of cognitive function, improved vascularization, and repair of skeletal muscle after cryo-injury (anti-geronic transposition), or as accelerated loss of cognitive function and neurogenesis (pro-geronic transposition). Other transposed phenotypes, as revealed solely through heterochronic parabiosis, may also be reported in the literature. There are also reports of candidate factors found in circulation that might be causally related to the transposition of these aging phenotypes; these are termed "circulating geronic factors" for purposes of this FOA. To date, these are proteins and peptides that pass between the young and old mice joined by parabiosis, due to anastomosis of their circulatory systems. Based on these novel findings and this novel experimental paradigm, the specific objective of this FOA is to test whether these candidate geronic factors are necessary for the transposition of aging phenotypes. The focus is on phenotypes transposed in heterochronic parabiosis and the candidate factors which are present and functional at physiological concentrations in circulation.
MiamiOH OARS

Smart and Connected Health | NSF - National Science Foundation - 0 views

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    The purpose of this program is to develop next generation health care solutions and encourage existing and new research communities to focus on breakthrough ideas in a variety of areas of value to health, such as sensor technology, networking, information and machine learning technology, decision support systems, modeling of behavioral and cognitive processes, as well as system and process modeling. Effective solutions must satisfy a multitude of constraints arising from clinical/medical needs, social interactions, cognitive limitations, barriers to behavioral change, heterogeneity of data, semantic mismatch and limitations of current cyberphysical systems. Such solutions demand multidisciplinary teams ready to address technical, behavioral and clinical issues ranging from fundamental science to clinical practice.
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    The purpose of this program is to develop next generation health care solutions and encourage existing and new research communities to focus on breakthrough ideas in a variety of areas of value to health, such as sensor technology, networking, information and machine learning technology, decision support systems, modeling of behavioral and cognitive processes, as well as system and process modeling. Effective solutions must satisfy a multitude of constraints arising from clinical/medical needs, social interactions, cognitive limitations, barriers to behavioral change, heterogeneity of data, semantic mismatch and limitations of current cyberphysical systems. Such solutions demand multidisciplinary teams ready to address technical, behavioral and clinical issues ranging from fundamental science to clinical practice.
MiamiOH OARS

14-611 Integrative Strategies for Understanding Neural and Cognitive Systems - 0 views

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    This solicitation describes the first phase of a new NSF program to support transformative and integrative research that will accelerate understanding of neural and cognitive systems. NSF seeks exceptional proposals that are bold, potentially risky, and transcend the perspectives and approaches typical of disciplinary research programs. This multi-directorate program is one element of NSF’s broader aim to foster innovation in Cognitive Science and Neuroscience, a multi-year effort that includes NSF’s participation in the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (http://www.nsf.gov/brain/). For FY 2015, this competition is organized around two research themes: Neuroengineering and Brain-Inspired Concepts and Designs and Individuality and Variation. Within each theme, general advances in theory and methods, technological innovations, educational approaches, enabling research infrastructure, and workforce development are all of significant interest.
MiamiOH OARS

Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent ... - 0 views

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    The Adolescent Brain Cognitive Development (ABCD) Study is collecting data on health and mental health, cognitive function, substance use, cultural and environmental factors, and brain structure and function from youth starting when they are 9-10 years-old repeatedly for 10 years and makes that data available to the scientific community through the NIMH Data Archive. The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications proposing the analysis of this public use dataset to increase knowledge of adolescent health and development. More information about the ABCD Study may be found on the ABCD Study web page (www.abcdstudy.org).
MiamiOH OARS

David Wechsler Early Career Grant for Innovative Work in Cognition - 0 views

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    The David Wechsler Early Career Grant for Innovative Work in Cognition supports early career psychologists pursuing innovative work in neuropsychology, intelligence and/or the assessment aspects of cognition. Those who work on positive applied neuropsychology are encouraged to apply. The grant is for up to $25,000.Applicants must: Be psychologists with an EdD, PsyD or PhD from an accredited university.Be no more than 10 years post doctoral.Have demonstrated competence and capacity to execute the proposed work.
MiamiOH OARS

International Sociological Association Seeks Applications for Science of Hope and Optim... - 0 views

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    Through its Science of Hope and Optimism Funding Initiative program, the association will award two-year grants of up to $250,000 for research projects that use a variety of methods to explore the nature of hope and optimism. Priority will be given to projects in cognitive, developmental, personality, health, and social psychology, as well as sociology. Interdisciplinary teams that include members from cognate areas - e.g., cognitive science, anthropology, nursing, and biology - are encouraged.
MiamiOH OARS

Targeted Neuroplasticity Training - Federal Business Opportunities: Opportunities - 0 views

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    DARPA seeks innovative proposals to develop technology for enhancing cognitive skill learning in healthy adults by using noninvasive peripheral neurostimulation to promote synaptic plasticity in the brain. The Targeted Neuroplasticity Training (TNT) program will elucidate the anatomical and functional map of the underlying neural circuity involved in regulating synaptic plasticity. The program seeks to demonstrate peripheral modulation of the neural circuit, connect neuroplasticity with cognitive improvements, and optimize intervention protocols for long term retention with no side effects.
MiamiOH OARS

DoD Psychological Health/ Traumatic Brain Injury, Complex Traumatic Brain Injury Rehabi... - 0 views

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    The FY18 PH/TBIRP CTRR-CRA is intended to support clinical research focused on understanding the clinical sequelae and mechanisms of recovery associated with TBI and TBI rehabilitation interventions. The overarching goals of this award are to address TBI-related impairments and deficits, including multimodal, and cognitive dysfunction to (1) develop and validate rehabilitation outcome measures; (2) systematically analyze standard of care cognitive interventions to identify optimal treatment ingredients; and (3) improve clinician-driven assessment strategies to guide return-to-duty decision making.
MiamiOH OARS

Clarifying the Relationship between Delirium and Alzheimers Disease and Related Dementi... - 0 views

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    This Funding Opportunity Announcement (FOA) invites applications that focus on clarifying the relationship between delirium and Alzheimer's disease and related dementias (ADRD). Specifically sought is research focusing on understanding why persons with ADRD are at increased risk to develop delirium, often with a worse prognosis compared to those without antecedent ADRD, and why patients who experience delirium are at higher risk to develop subsequent short- and/or long-term mild cognitive impairment or ADRD, often with an accelerated rate of cognitive decline compared to those without preceding delirium. Relevant research projects may focus on, but are not limited to, those that A) provide insight into possible common, sequential, causative, contributory and/or synergistic pathways underlying both ADRD and delirium, B) elucidate mechanisms that lead to the development of delirium against the background of aging and/or neurodegeneration, with particular emphasis on use of appropriate animal models, C) identify risk factors for the onset and/or progression of delirium in those with ADRD and vice versa, D) diagnose and assess one condition in the setting of the other, E) identify putative phenotypes of patients with co-existing ADRD and delirium, or F) test pharmacologic and/or non-pharmacologic strategies to prevent, treat, or reduce the impact of delirium in patients with ADRD and vice versa. Research supported by this FOA is intended to provide mechanistic insight to improve risk assessment, diagnosis, phenotyping, prevention, and management approaches for both delirium and ADRD.
MiamiOH OARS

Alzheimer's Drug-Development Program (U01 Clinical Trial Optional) - 0 views

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    The goal of this Funding Opportunity Announcement (FOA) is to provide funding support for the pre-clinical and early stage clinical (Phase I) development of novel small-molecule and biologic therapeutic agents that prevent Alzheimer's disease (AD), slow its progression or treat its cognitive and behavioral symptoms. Participants in this program will receive funding for therapy development activities such as medicinal chemistry, pharmacokinetics (PK), Absorption, Distribution, Metabolism, Excretion, Toxicology (ADMET), efficacy in animal models, formulation development, chemical synthesis under Good Manufacturing Practices (GMP), Investigational New Drug (IND) enabling studies and initial Phase I clinical testing. This program does not support research on basic mechanisms of disease, mechanisms of drug action, development of biomarkers, devices, non-pharmacological interventions (e.g., exercise, diet, cognitive training), repurposed drugs and combinations therapies, or discovery activities such as high throughput screening and hit optimization.
MiamiOH OARS

RFI | Templeton World Charity Foundation, Inc. - 0 views

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    We are looking for ideas that can lead to new multi-grant research portfolios on human flourishing. We are particularly interested in ideas for interdisciplinary scientific research towards discoveries that can promote physical, mental, social, and spiritual well-being. We welcome ideas that bridge gaps between empirical science and the humanities. Such ideas may include (but are not limited to):  Experimental testing of philosophically grounded models of human flourishing; Research on biological complexity in humans, including genetics, epigenetics, and microbiome research; Investigation of key psychological, neuroscientific, or human developmental concepts, such as (but not limited to) altruism, creativity, imagination, narrative, and meta-cognition; Research on cognitive, affective, or social capacities of individuals or groups; Studies of human biological or cultural evolution.
MiamiOH OARS

Science of Learning | NSF - National Science Foundation - 0 views

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    The Science of Learning program supports potentially transformative basic research to advance the science of learning. The goals of the SL Program are to develop basic theoretical insights and fundamental knowledge about learning principles, processes and constraints. Projects that are integrative and/or interdisciplinary may be especially valuable in moving basic understanding of learning forward but research with a single discipline or methodology is also appropriate if it addresses basic scientific questions in learning.   The possibility of developing connections between proposed research and specific scientific, technological, educational, and workforce challenges will be considered as valuable broader impacts, but are not necessarily central to the intellectual merit of proposed research. The program will support  research addressing learning in a wide range of domains at one or more levels of analysis including: molecular/cellular mechanisms; brain systems; cognitive affective, and behavioral processes; and social/cultural influences. The program supports a variety of methods including: experiments, field studies, surveys, secondary-data analyses, and modeling.
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    The Science of Learning program supports potentially transformative basic research to advance the science of learning. The goals of the SL Program are to develop basic theoretical insights and fundamental knowledge about learning principles, processes and constraints. Projects that are integrative and/or interdisciplinary may be especially valuable in moving basic understanding of learning forward but research with a single discipline or methodology is also appropriate if it addresses basic scientific questions in learning.   The possibility of developing connections between proposed research and specific scientific, technological, educational, and workforce challenges will be considered as valuable broader impacts, but are not necessarily central to the intellectual merit of proposed research. The program will support  research addressing learning in a wide range of domains at one or more levels of analysis including: molecular/cellular mechanisms; brain systems; cognitive affective, and behavioral processes; and social/cultural influences. The program supports a variety of methods including: experiments, field studies, surveys, secondary-data analyses, and modeling.
MiamiOH OARS

Hybrid Forecasting Competition (HFC) - 0 views

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    The HFC program seeks proposals for research to develop and test hybrid geopolitical forecasting systems. These systems will integrate human and machine forecasting components to create maximally accurate, flexible, and scalable forecasting capabilities. Human-generated forecasts may be subject to cognitive biases and/or scalability limits. Machine-generated (i.e., statistical, computational) forecasting approaches may be more scalable and data-driven, but are often ill-suited to render forecasts for idiosyncratic or newly emerging geopolitical issues. Hybrid approaches hold promise for combining the strengths of these two approaches while mitigating their individual weaknesses. Performers will develop systems that will integrate human and machine forecasting contributions in novel ways. These systems will compete in a multi-year competition to identify approaches that may enable the Intelligence Community (IC) to radically improve the accuracy and timeliness of geopolitical forecasts.
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    The HFC program seeks proposals for research to develop and test hybrid geopolitical forecasting systems. These systems will integrate human and machine forecasting components to create maximally accurate, flexible, and scalable forecasting capabilities. Human-generated forecasts may be subject to cognitive biases and/or scalability limits. Machine-generated (i.e., statistical, computational) forecasting approaches may be more scalable and data-driven, but are often ill-suited to render forecasts for idiosyncratic or newly emerging geopolitical issues. Hybrid approaches hold promise for combining the strengths of these two approaches while mitigating their individual weaknesses. Performers will develop systems that will integrate human and machine forecasting contributions in novel ways. These systems will compete in a multi-year competition to identify approaches that may enable the Intelligence Community (IC) to radically improve the accuracy and timeliness of geopolitical forecasts.
MiamiOH OARS

March of dimes research program - 0 views

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    This encompasses basic biological processes governing differentiation and development involving both human and animal model systems, genetics and genomics of these processes, clinical studies, reproductive health and environmental toxicology. Social and behavioral studies are encouraged concerning cognitive and behavioral risks that affect outcomes of pregnancy, the perinatal period, and subsequent child development. The latter may involve family units and those genes, toxicants and social determinants that adversely affect language or behavior.
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    This encompasses basic biological processes governing differentiation and development involving both human and animal model systems, genetics and genomics of these processes, clinical studies, reproductive health and environmental toxicology. Social and behavioral studies are encouraged concerning cognitive and behavioral risks that affect outcomes of pregnancy, the perinatal period, and subsequent child development. The latter may involve family units and those genes, toxicants and social determinants that adversely affect language or behavior.
MiamiOH OARS

Early Stage Clinical Trials for the Spectrum of Alzheimers Disease and Age-related Cogn... - 0 views

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    This Funding Opportunity Announcement (FOA) invites applications that propose to develop and implement early stage (Phase I or II) clinical trials of promising pharmacological and non-pharmacological interventions in individuals with age-related cognitive decline and in individuals with Alzheimer's disease (AD) across the spectrum from pre-symptomatic to more severe stages of disease, as well as to stimulate studies to enhance trial design and methods.
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