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The Common Fund Program - Accelerating Translation of Glycoscience: Integration and Accessibility - aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will enable researchers in all biomedical fields to dramatically advance our understanding of the roles of these complex molecules in health and disease and to not abandon glycan discovery due to the difficulty or inability to study them. The program will invest in three areas: facile methods and technologies for carbohydrate synthesis, accessible tools for probing and analyzing carbohydrates, and carbohydrate data integration and analysis tools. This R34 Funding Opportunity Announcement (FOA) invites applications for preliminary research and formation of research teams that will lay the groundwork for the inclusive, community-driven development of accessible resources for integration and analysis of carbohydrate and glycoconjugate structural, analytical, and interaction data in the context of comparable gene, protein, and lipid data. A subsequent FOA will invite applications for full support of that effort.

The Common Fund Program - Accelerating Translation of Glycoscience: Integration and Accessibility - aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will allow biomedical researchers to significantly advance our understanding of the roles of these complex molecules in health and disease. This program will enable investigators who might not otherwise conduct research in the glycosciences, to undertake the study of carbohydrate structure and function. In support of these aims, this FOA seeks applications for a community-driven project to develop computational and informatics tools for the manipulation, analysis, interpretation, and integration of glycoscience data. The product of this research will be accessible resources for analysis of carbohydrate and glycoconjugate structural, analytical, and interaction data, and integration of that information within the context of comparable gene, protein, and lipid data and databases.  

The Common Fund Program - Accelerating Translation of Glycoscience: Integration and Accessibility - aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will allow biomedical researchers to significantly advance our understanding of the roles of these complex molecules in health and disease. This program will enable investigators who might not otherwise conduct research in the glycosciences, to undertake the study of carbohydrate structure and function. In support of these aims, this FOA is intended to develop new approaches (catalytic methods, chemical/chemo-enzymatic methods, and technologies) to facilitate the rapid, robust, and affordable synthesis, and/or functionalization of bio-medically relevant glycans and glyco-conjugates representing 1) mammalian glycomes and 2) microbial glycans.

The Common Fund Program - Accelerating Translation of Glycoscience: Integration and Accessibility - aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will allow biomedical researchers to significantly advance our understanding of the roles of these complex molecules in health and disease. This program will enable investigators who might not otherwise conduct research in the glycosciences, to undertake the study of carbohydrate structure and function. This FOA solicits development of new, more easily accessible tools, reagents, and technologies to facilitate identification, tracking, manipulation, and analysis of glycans with their biological binding partners and determine their functions.

The Common Fund Program - Accelerating Translation of Glycoscience: Integration and Accessibility - aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will allow biomedical researchers to significantly advance our understanding of the roles of these complex molecules in health and disease. This program will enable investigators who might not otherwise conduct research in the glycosciences, to undertake the study of carbohydrate structure and function.

The Common Fund Program - Accelerating Translation of Glycoscience: Integration and Accessibility - aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will allow biomedical researchers to significantly advance our understanding of the roles of these complex molecules in health and disease. This program will enable investigators who might not otherwise conduct research in the glycosciences, to undertake the study of carbohydrate structure and function.

The Common Fund Program - Accelerating Translation of Glycoscience: Integration and Accessibility - aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will enable researchers in all biomedical fields to dramatically advance our understanding of the roles of these complex molecules in health and disease and to not abandon glycan discovery due to the difficulty or inability to study them. This FOA is intended to support development of new approaches (methods and technologies) to facilitate the rapid and affordable synthesis, production, and/or functionalization of bio-medically relevant glycans and glyco-conjugates representing 1) mammalian glycomes and 2) microbial glycans.

Eligibility Criteria Member of The Obesity Society (domestic or international) All career levels Applications from post-doctoral research fellows must have a mentor who is a current TOS member. Type of research eligible for award: Studies designed to look at the impact of macronutrient intake (carbs vs. proteins vs. fats) on overweight and obesity in children will be given top priority.   Available funding: One grant will be funded for $40,000 for a period of up to two years.     Focus of research proposals Potential questions might include, but are not limited to, such topics as: Present macronutrient make-up of diets of obese vs. normal wt. children Impact of high protein diet vs. high carbohydrate diet on body weight and body composition in children Optimal protein intake in children. Present studies (mainly in adults) suggest that consuming 25-30 gms protein per meal is preferable for enhancing muscle protein synthesis and promoting satiety. Is there an optimal range per meal in children?

The Common Fund Program - Accelerating Translation of Glycoscience: Integration and Accessibility- aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will enable researchers in all biomedical fields to dramatically advance our understanding of the roles of these complex molecules in health and disease and to not abandon glycan discovery due to the difficulty or inability to study them. This FOA solicits development of new, more easily accessible tools, reagents, and technologies to facilitate identification, tracking, manipulation, and analysis of glycans with their biological binding partners and determine their functions. This initiative may build on efforts that interface with existing technologies and procedures to make them easier to access and use. As applicable, efforts must consider: factors for scale-up; efforts to make instrumentation broadly accessible and cost-effective for the end-user; and compatibility of data generated with integration into existing databases.