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The purpose of this Funding Opportunity Announcement (FOA) is to support research that advances compounds towards FDA approval by leveraging NIDA funds with the strengths and resources of outside organizations, such as for-profit and not-for-profit entities, including academic institutions, pharmaceutical and biotechnology companies, private and public foundations, and small businesses. Applications from single entities that possess considerable resources for medications development will also be considered, provided the entity demonstrates a significant resource commitment to the proposed project. A resource commitment from a single entity could, for example, consist of salary support for key personnel or production and formulation of clinical trial material. It is anticipated that in comparison with traditional grant-funded research, strategic alliances will increase the pace at which medications to treat Substance Use Disorders (SUDs) move through the drug development process. Both the project period and budget of the grant are consistent with the objective of accelerating the pace of medications development compared to traditional research project grant funding. Project aims can range from the development of a new molecular entity to the expansion of an existing medication's clinical indication(s). Each project should have a defined entry and exit point in the medications development pathway, with the objective of advancement in the FDA approval process. It is hoped that support for these collaborations will accelerate the rate of medications development for SUDs.

The purpose of this Funding Opportunity Announcement (FOA) is to accelerate the discovery and development of medications to treat Cannabis Use Disorders (CUDs) using the UG3/UH3 mechanism. The objective is to advance medications toward the ultimate goal of obtaining FDA approval. Advances in understanding the cannabinoid systems and the effects of marijuana on the brain, coupled with the availability of both novel and marketed medications that may be efficacious to treat these disorders, offer unprecedented opportunities to develop safe and effective pharmacotherapies for CUDs. The compounds to be evaluated can be small molecules or biologics. They can be tested in pre-clinical models and/or for the clinical manifestations of CUDs or their consequences such as withdrawal, craving, or cannabis use relapse. Applications may focus on the development of new chemical entities, new formulations of marketed medications available for other indications, or combinations of medications that hold promise for the treatment of CUDs. The UG3/UH3 Phase Innovation Awards Cooperative Agreement involves 2 phases. The UG3 is to support a project with specific milestones to be accomplished by the end of the 2-year period. The UH3 is to provide funding for 3 years to a project that successfully completed the milestones set in the UG3. UG3 projects that have met their milestones will be administratively considered by NIDA and prioritized for transition to the UH3 phase. Investigators responding to this FOA must address both UG3 and UH3 phases.

This Funding Opportunity Announcement (FOA) invites grant applications from institutions/organizations that propose to build research infrastructure to promote external collaboration with the medical rehabilitation community. The aim of this FOA is to create a national network of research cores that provide access to collateral expertise in biomedical, behavioral, engineering, and/or psychosocial fields that is particularly relevant to medical rehabilitation research. We are particularly interested in supporting infrastructure programs in clinical trial design, engineering and the environment, individualized medical rehabilitation and dynamic reassessment, and applied behavioral supports for rehabilitation research and healthy outcomes. However, other areas of expertise may be proposed provided they offer unique research opportunities and have potential for promoting medical rehabilitation research and improving outcomes for people with disabilities. In response to this FOA, applicants should propose a program of research resources and collaborative opportunities in a specific research domain. This may be accomplished through a workshops, written material, and websites, consultations, collaborations, and pilot funding. In addition, the research core may support activities within the grantee institution related to technique development, adaptation, and validation. To accomplish the aims of the FOA, applicants may propose collaborations to other institutional sites, provided that they cover the appropriate administrative and logistical issues.

Applications to the Fiscal Year 2017 (FY17) Psychological Health and Traumatic Brain Injury Research Program (PH/TBIRP) in the area of Applied Behavior Analysis for Autism are being solicited for the Defense Health Agency (DHA) J9, Research and Development Directorate, by the U.S. Army Medical Research Acquisition Activity (USAMRAA) using delegated authority provided by United States Code, Title 10, Section 2358 (10 USC 2358). As directed by the Office of the Assistant Secretary of Defense for Health Affairs (OASD[HA]), the DHA manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The U.S. Army Medical Research and Materiel Command (USAMRMC) Congressionally Directed Medical Research Programs (CDMRP) provides PH/TBIRP execution management support aligned with specific DHP research program areas. The execution management agent for this Program Announcement is the CDMRP, with strategic oversight from the DHA. The PH/TBIRP was established by Congress in FY07 in response to the devastating impact of traumatic brain injury (TBI) and psychological health (PH) issues, including post-traumatic stress disorder, on our deployed Service members in Iraq and Afghanistan. The PH/TBIRP mission is to establish, fund, and integrate both individual and multi-agency research efforts that will lead to improved prevention, detection, and treatment of PH issues and TBI. The vision of the PH/TBIRP is to prevent, mitigate, and treat the effects of traumatic stress and TBI on function, wellness, and overall quality of life for Service members as well as their caregivers and families. The DHA leverages PH/TBIRP funding to complement DHP core research and development funding assigned to study PH and TBI.

The HRP contains six Elements: Space Radiation, Human Health and Countermeasures, Exploration Medical Capability, Behavioral Health and Performance, Space Human Factors and Habitability, and International Space Station Medical Project. Fourteen disciplines or areas support the Program: Behavioral Health and Performance, Bone, Cardiovascular, Extravehicular Activity, Immunology, Medical Capabilities, Muscle, Nutrition, Pharmacology, Radiation, Sensorimotor, Advanced Food Technology, Advanced Environmental Health, and Space Human Factors Engineering. The National Space Biomedical Research Institute (NSBRI) is a non-profit organization competitively selected by NASA that uses an integrated team approach to advance biomedical research and countermeasure development. NSBRI works in close partnership with the HRP through a Cooperative Agreement. The NRA will cover all aspects of research to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration, and to ensure safe and productive human spaceflight. Awards generally range from under $100K per year for focused, limited efforts (e.g., data analysis) to $450K per year for extensive activities (e.g., development of scientific hardware). The funds available for awards in each program element offered in the NRA range from less than one to several million dollars, which allow selection from a few to as many as a dozen proposals depending on the program objectives and the submission of proposals of merit. Awards will be made as grants. The period of performance for an award will be one to five years. Any changes or modifications to any of these guidelines will be specified in the descriptions of the relevant program elements in the solicited research response area appendices of this solicitation. 

Competitive applications will focus on studies that achieve one or more of the following goals: - Characterize disease progression for people with Parkinson's - Evaluate the utility of different instruments and/or instrument sub-items in measuring burden of disease, especially in individuals within the first two (2) years of Parkinson's diagnosis - Identify the role of pharmacological, medical device and/or non-medical interventions on managing Parkinson's symptoms and long-term health outcomes - Predict the future health status of participants without Parkinson's based on disease risk variables and model their likelihood of developing Parkinson's - Determine elements of disease experience that drive patient preference and risk tolerance - Explore the factors that affect volunteer compliance and completeness of participation in an online study - Determine how economic factors, patient-physician communication and lifestyle factors influence medical treatment and long-term health outcomes in people with Parkinson's - Analyst's choice: Researchers can submit their own analysis topics based on available Fox Insight data especially as it relates to longitudinal analyses

The Klarman Family Foundation is interested in providing strategic investment in translational research that will accelerate progress in developing effective treatments for anorexia nervosa, bulimia nervosa and binge eating disorder. The Program's short-term goal is to support the most outstanding science and expand the pool of scientists whose research explores the basic biology of feeding, anorexia nervosa, bulimia nervosa, and/or binge eating disorder. The long-term goal is to improve the lives of patients suffering from these conditions. Examples of funding areas include but are not limited to molecular genetic analysis of relevant neural circuit assembly and function; genetic and epigenetic research; animal models created by genetically altering neural circuits; and testing of new chemical entities that might be used in animal models as exploratory treatments.  Please note that imaging studies involving humans are not eligible. Investigators conducting research in the neuro-circuitry of fear conditioning or reward behavior may also apply but must justify the relevance of their research projects to the basic biology of eating disorders. Clinical psychotherapeutic studies, medication trials and research in the medical complications of these disorders are outside the scope of this Program.

This initiative is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress. This Phased Innovation Awards Cooperative Agreement Funding Opportunity Announcement (FOA) solicits applications to support a collaborative research infrastructure involving an interdisciplinary team of basic and clinical scientists to develop the foundation for an experimental medicine approach to behavior change. Research supported by this FOA is meant to support activities focused on behavior change targets in the domain of interpersonal and social processes through four main target validation steps: 1. Identify a set of putative targets within the interpersonal and social processes domain that are implicated in medical regimen adherence and at least one other health behavior; 2. Leverage existing or develop new experimental or intervention approaches to engage identified targets; 3. Identify or develop appropriate assays (measures) to permit verification of target engagement; 4. Test the degree to which engaging identified targets produces a desired change in medical regimen adherence and at least one other health behavior. While testing target engagement in specific clinical samples is permitted, the targets identified and the behavior change outcomes measured should be selected based on their hypothesized relevance to at least two clinical endpoints or disease conditions. Funds from the NIH will be made available through the UH2/UH3 Phased Innovation Awards Cooperative Agreement mechanism.The initial UH2 phase will support steps 1-3 above. UH2 projects that have met their objectives and agreed upon milestones will be administratively considered by NIH and prioritized for transition to the UH3 va

The Autism Science Foundation is inviting applications for its Pre- and Postdoctoral Training Awards and Medical School Gap Year Research Training Awards from graduate students, medical students, and postdoctoral fellows interested in pursuing careers in basic and clinical research relevant to autism spectrum disorders. The proposed training must be scientifically linked to autism and may be broadened to include training in a closely related area of scientific research, including but not limited to human behavior across the lifespan (language, learning, behavior, communication, social function, motor skills and planning, epilepsy, sleep, repetitive disorders); neurobiology (anatomy, development, neuroimaging); pharmacology; neuropathology; genetics; epigenetics; genomics; epigenomics; immunology; molecular and cellular mechanisms; studies employing model organisms and systems; and studies of treatment and service delivery.

This notice announces the opportunity to apply for funding under the Innovations in Care Coordination for Children and Youth with Autism Spectrum Disorders (ASD) and Other Developmental Disabilities (DD) Program. The purpose of this program is to build on past HRSA programs (HRSA-16-048 and HRSA-13-207) to improve access to coordinated and integrated care for children with, or at risk for, ASD/DD and their families in medically underserved areas and populations.[1],[2] The purpose and objectives of this program will be accomplished by implementing the following two strategies: Family Navigation - Increasing family navigation services to improve communication between families and primary and specialty providers; link children with/at risk for ASD/DD to diagnostic evaluations, ASD/DD services, and community resources; and provide education to families of children with/at risk for ASD/DD to improve self-efficacy in navigating the system of care for children with/at risk for ASD/DD; and Provider Education - Providing education, training, and technical assistance to providers, and community based-organizations providing services to ASD/DD on improving care for children with/at risk for ASD/DD through a learning community. [1] At risk for ASD/DD can be defined as children who have been identified through primary care developmental surveillance as needing further screening or evaluation for ASD/DD. [2] HRSA definition for Medically Underserved Areas: https://datawarehouse.hrsa.gov/topics/shortageareas.aspx.

HIV+ alcohol users remain at high risk for medication non-adherence and rapid disease progression, medication toxicities, organ failure, and poor viremic control, leading to increased risk of transmission and premature death. Recent advances in technology and biomedical science (e.g., new pharmacological agents, alcohol and inflammation biomarkers, internet and mobile technology) open new opportunities for strengthening the quality of HIV/alcohol-related implementation research through utilization of novel technology and biomarkers. This initiative seeks to advance knowledge on implementation and comparative effectiveness of alcohol-focused interventions among HIV+ individuals. Multiple factors need to be investigated, including potentially important patient and provider characteristics, and the organizational, financial, and structural factors that facilitate or inhibit the delivery of evidence-based services for HIV+ individuals with a range of severity of alcohol use problems. The overall goal is to inform clinical decision-making to implement effective interventions that will improve prevention, care, and outcomes across the continuum of HIV and alcohol problem severity and patterns of alcohol use. This solicitation is divided into two major topics. An application may choose to address one or both. These topics include: 1) comparative effectiveness research focused on understanding factors related to early detection, patient engagement and retention in appropriate alcohol and HIV care, and achieving and maintaining optimal treatment responses in diverse settings, and 2) modeling and testing alternative implementation approaches to improve uptake and scaling-up of effective interventions and reduce HIV disease transmission and progression.

The research will fall into one or more categories corresponding to HRP's five Elements: Space Radiation, Human Health Countermeasures, Exploration Medical Capability, Human Factors and Behavioral Performance, and International Space Station Medical Projects. This NRA covers all aspects of research to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration.

NIFA requests applications for the Mental Health Research Project (MHRP) for the fiscal year FY 2017 to support the Air Force Medical Operations Agency (AFMOA) MHRP in promoting the psychological health and well being for Airmen and there families through staff development, consultation, program and resource development; program evaluation, and data tracking.The primary objective for this project is to assess, develop, and evaluate programming to treat and prevent mental health problems to support the Mental Health Division of the Air Force Medical Operations Agency (AFMOA).This work also supports the mission of the DoD-USDA Partnership for Military Families Memorandum of Understanding (MOU) signed in 2010 by NIFA and DoD senior leadership. The goal of the MOU is "…to enhance federal interagency coordination and build capacity for partnerships and collaboration among the agencies and across public and private sectors to sustain programs and services for military service members and their families."

NASA's Human Research Program (HRP) has released solicited research response area NRA 80JSC017N0001-BPBA "Topics in Biological, Physiological, and Behavioral Adaptations to Spaceflight: Integrated One Year Mission Project and Other Opportunities" that solicits applied research in support of HRP goals and objectives. The first topic in the solicitation is for proposals in the area of Analyses of the Temporal Nature of Human Adaptation to Long-Duration Low-Earth Orbit Missions. HRP has a requirement for sufficient crewmember experience at one year in spaceflight to demonstrate the presence or absence of unacceptable deleterious physiological, psychological and medical effects of spaceflight on human health and performance beyond the experience base of six-month expeditions and to permit extrapolation to early interplanetary expeditions with durations of up to two to three years. Therefore, HRP is proposing an integrated One-Year Mission Project on the International Space Station (ISS) consisting of five one-year missions five standard-duration six-month missions paralleling the year-long expeditions, and five short-duration crew vehicle exchange expeditions lasting up to two months to occur at the mid-point of each 1YM. Proposals are solicited by NASA in the additional areas of Biological, Physiological, and Behavioral Functions of Mice during Partial (0 - 1) G-Exposures Provided by Centrifugation on the International Space Station; Novel Spaceflight-Associated Neuro-Ocular Syndrome Hypotheses and Countermeasures; Medical Countermeasures Targeting Multiple Tissues at Risk from Exposure to Space Radiation; Individual and Team Problem-Solving Skills Training for Exploration Missions; Sensory Stimulation for Cognitive and Behavioral Health; and Human Capabilities Assessments for Autonomous Missions (HCAAM) Virtual NASA Specialized Center of Research.

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites applications to evaluate the cumulative and progressive effects on brain structure and cognitive/behavioral function of combined HIV infection and alcohol abuse. This project has recruited and longitudinally tracked a large cohort of individuals with HIV infection, or alcohol abuse, or the comorbid condition. As members of this cohort are growing older and living well longer due to antiretroviral medications, this project is well suited to address several questions of current interest in the HIV-AIDS research community. These questions include the effects of coinfection with the Hepatitis C virus, the involvement of peripheral neuropathy as a factor in frailty, potential neurotoxic effects of antiretroviral medications, and interactive effects with advancing age on sensory and motor functioning.

The Autism Science Foundation is inviting applications for its Pre- and Postdoctoral Training Awards from graduate students, medical students, and postdoctoral fellows interested in pursuing careers in basic and clinical research relevant to autism spectrum disorders. The proposed training must be scientifically linked to autism and may be broadened to include training in a closely related area of scientific research, including but not limited to human behavior across the lifespan (language, learning, behavior, communication, social function, motor skills & planning, epilepsy, sleep, repetitive disorders), neurobiology (anatomy, development, neuroimaging), pharmacology, neuropathology, genetics, epigenetics, genomics, epigenomics, immunology, molecular and cellular mechanisms, studies employing model organisms and systems, and studies of treatment and service delivery. Special consideration will be given to projects focused on gender issues in autism. This includes studies examining the female protective effect, neurobiological and neuroanatomical examination of the female autism brain, diagnostic differences and challenges in females, the female phenotype, and health and lifespan issues, including vocational services and employment. ASF also invites studies focused on unaffected siblings and recurrence risk in the offspring of unaffected siblings. ASF is also interested in supporting research on the neurobiology and molecular biology of autism using post-mortem brain tissue. The one-year awards include $25,000 for predoctoral and medical students and $35,000 for postdoctoral students.

HIV+ alcohol users remain at high risk for medication non-adherence and rapid disease progression, medication toxicities, organ failure, and poor viremic control, leading to increased risk of transmission and premature death. Recent advances in technology and biomedical science (e.g., new pharmacological agents, alcohol and inflammation biomarkers, internet and mobile technology) open new opportunities for strengthening the quality of HIV/alcohol-related implementation research through utilization of novel technology and biomarkers. This initiative seeks to advance knowledge on implementation and comparative effectiveness of alcohol-focused interventions among HIV+ individuals. Multiple factors need to be investigated, including potentially important patient and provider characteristics, and the organizational, financial, and structural factors that facilitate or inhibit the delivery of evidence-based services for HIV+ individuals with a range of severity of alcohol use problems. The overall goal is to inform clinical decision-making to implement effective interventions that will improve prevention, care, and outcomes across the continuum of HIV and alcohol problem severity and patterns of alcohol use

NIFA requests applications for the Army Family Advocacy Program: Research and Prevention (ARMY) for fiscal year (FY) 2016 to 1) determine the effectiveness for child and domestic/partner abuse case treatments for Army Medical Command and 2) develop evidence-based information for prevention of child abuse and domestic/partner abuse for Army Installation Management Command.

NIFA requests applications for the Army Family Advocacy Program: Research and Prevention (ARMY) for fiscal year (FY) 2016 to 1) determine the effectiveness for child and domestic/partner abuse case treatments for Army Medical Command and 2) develop evidence-based information for prevention of child abuse and domestic/partner abuse for Army Installation Management Command.

The goal of the Smart and Connected Health (SCH) Program is to accelerate the development and use of innovative approaches that would support the much needed transformation of healthcare from reactive and hospital-centered to preventive, proactive, evidence-based, person-centered and focused on well-being rather than disease. Approaches that partner technology-based solutions with biobehavioral health research are supported by multiple agencies of the federal government including the National Science Foundation (NSF) and the National Institutes of Health (NIH). The purpose of this program is to develop next generation health care solutions and encourage existing and new research communities to focus on breakthrough ideas in a variety of areas of value to health, such as sensor technology, networking, information and machine learning technology, decision support systems, modeling of behavioral and cognitive processes, as well as system and process modeling. Effective solutions must satisfy a multitude of constraints arising from clinical/medical needs, social interactions, cognitive limitations, barriers to behavioral change, heterogeneity of data, semantic mismatch and limitations of current cyberphysical systems. Such solutions demand multidisciplinary teams ready to address technical, behavioral and clinical issues ranging from fundamental science to clinical practice.

The goal of the Smart and Connected Health (SCH) Program is to accelerate the development and use of innovative approaches that would support the much needed transformation of healthcare from reactive and hospital-centered to preventive, proactive, evidence-based, person-centered and focused on well-being rather than disease. Approaches that partner technology-based solutions with biobehavioral health research are supported by multiple agencies of the federal government including the National Science Foundation (NSF) and the National Institutes of Health (NIH). The purpose of this program is to develop next generation health care solutions and encourage existing and new research communities to focus on breakthrough ideas in a variety of areas of value to health, such as sensor technology, networking, information and machine learning technology, decision support systems, modeling of behavioral and cognitive processes, as well as system and process modeling. Effective solutions must satisfy a multitude of constraints arising from clinical/medical needs, social interactions, cognitive limitations, barriers to behavioral change, heterogeneity of data, semantic mismatch and limitations of current cyberphysical systems. Such solutions demand multidisciplinary teams ready to address technical, behavioral and clinical issues ranging from fundamental science to clinical practice.

To facilitate the professional development of rheumatology, nephrology and dermatology fellows, in the U.S. and Canada, interested in lupus research towards a career as an independent clinician-scientist at an academic, medical, or research institution, with a research program having considerable focus on the investigation of basic, clinical, translational, behavioral or epidemiological lupus research.

To facilitate the professional development of rheumatology, nephrology and dermatology fellows, in the U.S. and Canada, interested in lupus research towards a career as an independent clinician-scientist at an academic, medical, or research institution, with a research program having considerable focus on the investigation of basic, clinical, translational, behavioral or epidemiological lupus research.