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The General & Age Related Disabilities Engineering (GARDE) program supports fundamental engineering research that will lead to the development of new technologies, devices, or software that improve the quality of life of persons with disabilities. Research may be supported that is directed toward the characterization, restoration, and/or substitution of human functional ability or cognition, or to the interaction of persons with disabilities and their environment. Areas of particular interest are disability-related research in neuroengineering and rehabilitation robotics. Emphasis is placed on significant advancement of fundamental engineering knowledge that facilitates transformative outcomes. We discourage applications that propose incremental improvements. Applicants are encouraged to contact the Program Director prior to submitting a proposal.

The General & Age Related Disabilities Engineering (GARDE) program supports fundamental engineering research that will lead to the development of new technologies, devices, or software that improve the quality of life of persons with disabilities. Research may be supported that is directed toward the characterization, restoration, and/or substitution of human functional ability or cognition, or to the interaction of persons with disabilities and their environment. Areas of particular interest are disability-related research in neuroengineering and rehabilitation robotics. Emphasis is placed on significant advancement of fundamental engineering knowledge that facilitates transformative outcomes. We discourage applications that propose incremental improvements. Applicants are encouraged to contact the Program Director prior to submitting a proposal. 

This Small Business Technology Transfer (STTR) Funding Opportunity Announcement (FOA) seeks to stimulate research on and development of (R&D) wearable, mobile-based, or other technology (software applications, etc.) to collect continuous data on variables assessing functions of daily activities in individuals at risk for or with Alzheimer's disease (AD) or AD-related dementias (ADRD).

This Funding Opportunity Announcement (FOA) intends to support pilot studies aimed to establish molecular, anatomical, and functional cell and circuit census data from selected brain regions of young and old C57BL/6J mice. This will complement and build on current BRAIN Initiative efforts while informing a design for a comprehensive characterization of cells and circuits in the brain across the lifespan, including the generation of a comprehensive 3D brain cell reference atlas of the aging mouse brain.

The purpose of NIDILRR's ARRT program, which is funded through the Disability and Rehabilitation Research Projects and Centers Program, is to provide advanced research training and experience to individuals with doctorates, or similar advanced degrees, who have clinical or other relevant experience. ARRT projects train rehabilitation researchers, including researchers with disabilities, with particular attention to research areas that support the implementation and objectives of the Rehabilitation Act, and that improve the effectiveness of services authorized under the Rehabilitation Act. ARRT projects must provide advanced research training to eligible individuals to enhance their capacity to conduct high-quality multidisciplinary disability and rehabilitation research to improve outcomes for individuals with disabilities in NIDILRR's major domain of health and function.

To study in vivo synaptic structure and function in Alzheimer's and related dementia; and to advance development of methods to study synapses in animal models and humans.

To study in vivo synaptic structure and function in Alzheimer's and related dementia; and to advance development of methods to study synapses in animal models and humans.

This Funding Opportunity Announcement (FOA) invites applications that expand on foundational research demonstrating generally improved emotional function and emotion regulation with aging, to further clarify the trajectories of change in emotion processing and linked neurobiological factors in adults who are aging normally, as well as in individuals with mild cognitive impairment (MCI), Alzheimer's disease (AD), and Alzheimer's disease-related dementias (ADRD). The goal is three-fold: to advance understanding of

Objective To help trainees initiate careers in cardiovascular and stroke research while obtaining significant research results under the supervision of a sponsor or mentor; supports individuals before they're ready for some stage of independent research. Science Focus Research broadly related to cardiovascular function and disease and stroke, or to related clinical, basic science, bioengineering or biotechnology, and public health problems, including multidisciplinary efforts.

The goal of this FOA is to support research that will lead to a greater understanding of complex mechanisms by which the brain glymphatic system and meningeal and peripheral lymphatic systems change in normal and pathological brains. This knowledge is critical to determine whether a functional impairment or disruption of these systems may be involved in neurological disorders that are associated with immune system dysfunction, such as Alzheimer's disease.

This FOA invites applications on descriptive, basic and translational studies of APOE2 to delineate the functional effects of ApoE2 on healthy aging of the brain and other tissues. The primary focus is on the "APOE2-Aging-AD" relationship and the mechanistic effects of the protective variant on aging and potential interaction/cross talk between tissues in the aging process and AD. These studies are expected to generate new mechanistic insights that involve brain and/or other organs and assist in the identification of potential prognostic and diagnostic markers and therapeutic targets for AD and other age-related cognitive disorders. Eventually, the findings from these studies could lead to translational research opportunities not only to prevent or delay the onset of AD, but also to protect against multiple age-related conditions.  

This FOA is soliciting research projects that would advance biomedical research on the role of peripheral proteostasis on brain structure and function during aging and in Alzheimer's disease, facilitating the identification of molecular and cellular markers of normal brain aging and brain aging during pathological conditions.

This FOA invites exploratory comparative biology research projects assessing how different animal species respond to challenges and damage to cellular physiology pathways that might influence the onset of Alzheimer's and other neurodegenerative diseases as well as resilience to them, such as adaptation to stress, macromolecular damage, proteostasis and stem cell function and regeneration.    

The "Mechanisms of cellular death in NeuroDegeneration" (MCDN) funding program's overall goal is to discover and understand the mechanisms and pathophysiological processes by which brain cell loss is mediated in disease and thereby seek insights and potential targets for therapeutic interventions that would sustain healthy brain function.

The Jointly Sponsored NIH Predoctoral Training Program in the Neurosciences (JSPTPN) is an institutional program that supports broad and fundamental research training in the neurosciences. In addition to a broad education in the neurosciences, a key component will be a curriculum that provides a strong foundation in experimental design, statistical methodology and quantitative reasoning. . JSPTPN programs are intended to be two years in duration, and students may only be appointed to this training grant during the first 2 years of their graduate research training. The primary objective is to prepare individuals for careers in neuroscience that will have a significant impact on our understanding of nervous system function and the health-related research needs of the nation.

Projects concerned with understanding the basic mechanisms of aging that have direct relevance to human aging will be considered if they show the potential to lead to clinically-relevant strategies that address human aging and healthspan. Projects investigating age-related diseases are also supported, if approached from the point of view of how basic aging processes may lead to these outcomes. Projects concerning mechanisms underlying common geriatric functional disorders such as frailty will also be considered. Projects that are strictly clinical in nature such as the diagnosis and treatment of disease, health outcomes, or the social context of aging are not eligible.

Our nation's health delivery system frequently does not meet the unique needs of older adults. Wide gaps remain between evidence-based approaches, nationally recognized best practices, and how care is currently delivered for many conditions that disproportionately affect this population. Strong leadership is needed to ensure that promising innovations are implemented to improve health and functional outcomes in older adults. The Practice Change Leaders program is a one-year opportunity to gain enhanced leadership skills and content expertise to positively influence care for older adults. Leaders complete a project aimed at integrating improved care for older adults within their organization, allowing them to remain at their full time job throughout the one-year program.

The purpose of this FOA is to stimulate the development of innovative research strategies aimed at increasing the understanding of the molecular and cellular changes in the cytoskeleton that occur during the aging process.  Applications considering the effect of age on factors such as cytoskeleton structure and function, the impact of the cytoskeleton on intracellular organelle interactions, and signaling or regulatory molecules controlling cellular architecture are encouraged.  There is also interest in studying the role of the cytoskeleton in nuclear-cytoplasmic communications, and in spatio-temporal relationships during the aging process and in age-related diseases.

The General & Age Related Disabilities Engineering (GARDE) program supports research that will lead to the development of new technologies, devices, or software for persons with disabilities.  Research may be supported that is directed to the characterization, restoration, and/or substitution of human functional ability or cognition, or to the interaction of persons with disabilities and their environment.  Areas of particular recent interest are disability-related research in neuroscience/neuroengineering and rehabilitation robotics.  Emphasis is placed on significant advancement of fundamental engineering and scientific knowledge and not on incremental improvements.  Proposals should advance discovery or innovation beyond the frontiers of current knowledge in disability-related research.  Applicants are encouraged to contact the Program Director prior to submitting a proposal. Undergraduate Engineering Design Projects are also supported, especially those that provide prototype "custom-designed" devices or software for persons with disabilities.  The education of undergraduate engineering students is enhanced through Undergraduate Engineering Design Projects' awards supported by the GARDE program. 

Funds are available from the Group Foundation for Advancing Mental Health to support group psychotherapy research that focuses on one of five clinical populations: children, the elderly, the chronic mentally ill, substance abusers and significantly ill patients with marked functional impairment.  The Group Psychotherapy Foundation is seeking research-focused, rather than program-focused, applications.

The purpose of this FOA is to invite pilot/feasibility (R03) projects on: 1) descriptive studies to identify putative juvenile protective factors, 2) experimental studies to test hypotheses about their effects on aging and 3) translational studies to explore the potential risks and benefits of maintaining or modulating the level of juvenile protective factors in adult life. Juvenile protective factors are physiological factors that maintain or enhance certain functions across all or some stages of post-natal maturation, but which diminish or disappear during transitions between developmental stages (e.g., infancy, adiposity rebound, adrenarche, puberty, growth cessation). This FOA is uniquely focused on studies which involve comparisons between post-natal developmental stages or pre- vs. post-maturational changes to identify potential juvenile protective factors and their effects on aging. Pilot studies in in vitro models, in laboratory animals or in humans may be proposed.