This site had online talking story books that could be used on an interactive whiteboard. This could be done as a whole class or used in small groups of students.
ReadWriteThink has activities designed from grades K-12. You can sort the activities based on what grade level you are looking for. It has activities such as word sorts, venn diagrams, poetry helpers, and many more literacy activities to be used whole class on an interactive whiteboard or individually.
This is a page on the scholastic website that has interactive whiteboard activities for Earth Day. These activities include lessons on water conservation and recycling etc.
This blog is for psychologists, teachers, speech and language therapists, related professionals, parents, technologists, and others interested in using technology more effectively to support engaged learning, cognitive development, communication, social-emotional skills development, health & wellness, transition-to-adulthood planning, and assessment linked to prevention and intervention.
This is an example of using Powerpoint to create a game of Jeopardy with your students. It creates an element of interaction that otherwise wouldn't be possible with the computer.
Reference: "Revolutionizing Instruction for Autistic Students Utilizing Interactive Whiteboards" was a presentation in ISTE's Technology in Practice Webinar Series, from September 2008. Information on this page could provide a starting place for further research/resources.
EducationCity is a subscription website that features games for grades K-6 in math, language arts, and science. With the subscription, students can keep track of their progress in the games with the "success tracker", and then the teacher gets a compilation of student scores, broken down by subject and graphed to show how they are doing. It can be used individually with students, or in the "Interactive Whiteboard Mode" whole class/small group.