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During the development of the brain, young neurones need to form connections with other cells. But equally important, they need to avoid making connections with themselves.

If we knew what made some people vulnerable to the effects of tryptophan depletion, we would be a long way towards understanding depression. We still don't. But it's something to do with serotonin. In some people, in some circumstances, serotonin is the only thing between happiness and despair. No, really. (Neuroskeptic)