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mongkolsong

What is a Genetic Disease? | GeneticAlliance.org - 0 views

  • A mutation is a change in the letters (DNA sequence) that make up a gene. This is sometimes referred to as a “spelling” mistake.
  • Genetic diseases can be inherited because they are mutations in the germ cells of the body—the cells involved in passing genetic information from parents to offspring. Genetic diseases can also result from changes in DNA in somatic cells, or cells in the body that are not germ cells.
shanegladwin

How do genes affect your health? - 0 views

  • Genes affect our chances of having several common illnesses, like heart disease, asthma and diabetes but so do many other factors, such as diet and lifestyle.
  • Many genetic and non-genetic factors affect our health, but scientists don't yet know what they all are, or how they interact with each other.
suhak1234

Genetic disorders | Better Health Channel - 1 views

  • Occasionally an error occurs during the division: for example, the egg or sperm might be missing a chromosome (22 chromosomes) or have an extra one (24 chromosomes), so at conception the baby has either too few (45) or too many (47) chromosomes. A well-known example of this type of genetic disorder is Down syndrome, where a person has 47 chromosomes rather than 46.
  • Over 1,000 known disorders are caused by chromosome abnormalities. A chromosome disorder means there is a change in either the structure or the number of chromosomes. This can happen in three main ways: The altered chromosome is passed from the parent to the child The abnormality happens when either the sperm or egg (germ cells) is created Soon after conception.
  • Around 6,000 known genetic disorders are caused by inheriting an altered gene.
rkupperstein

HowStuffWorks "What have we learned from the Human Genome Project?" - 1 views

  • adenine (A), which pairs with thymine (T), and cytosine (C), which pairs with guanine (G).
shanegladwin

Cloning Dolly the sheep | Animal Research - 0 views

  • Dolly the sheep, as the first mammal to be cloned from an adult cell, is by far the world's most famous clone. However, cloning has existed in nature since the dawn of life. From asexual bacteria to ‘virgin births’ in aphids, clones are all around us and are fundamentally no different to other organisms. A clone has the same DNA sequence as its parent and so they are genetically identical.
  • To produce Dolly, scientists used an udder cell from a six-year-old Finn Dorset white sheep. They had to find a way to 'reprogram' the udder cells - to keep them alive but stop them growing – which they achieved by altering the growth medium (the ‘soup’ in which the cells were kept alive). Then they injected the cell into an unfertilised egg cell which had had its nucleus removed, and made the cells fuse by using electrical pulses. The unfertilised egg cell came from a Scottish Blackface ewe. When the research team had managed to fuse the nucleus from the adult white sheep cell with the egg cell from the black-faced sheep, they needed to make sure that the resulting cell would develop into an embryo. They cultured it for six or seven days to see if it divided and developed normally, before implanting it into a surrogate mother, another Scottish Blackface ewe. Dolly had a white face.
  • Since 1996, when Dolly was born, other sheep have been cloned from adult cells, as have cats, rabbits, horses and donkeys, pigs, goats and cattle. In 2004 a mouse was cloned using a nucleus from an olfactory neuron, showing that the donor nucleus can come from a tissue of the body that does not normally divide.
  • ...1 more annotation...
  • This has created a market for commercial services offering to clone pets or elite breeding livestock, but still with a $100,000 price-tag.
rkupperstein

All About The Human Genome Project (HGP) - 4 views

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    The HGP was very important to our research into gene therapy.
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