The wireframing process is the straight-to-the-point and completely non-tech stage of any web project. It only requires that you define a skeletal outline of essential page elements such as headers, footers, navigation and content area and should illustrate how to cater and respond to any possible interaction from a user.
If you have anything to do with the world of publishing, you know about Adobe InDesign. It is one of the best software for online and offline publishing including creation of awesome posters, print layouts, magazines, eBooks and Interactive Documents.