The Causes of and Attainable Options to Acne Vulgaris - 0 views
started by Mann Armstrong on 03 Jul 13
started by Mann Armstrong on 03 Jul 13
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- An inflamed spot occurs due to the release of inflammatory fatty acids by a certain bacterium identified as p.acnes, which causes the bodys defence systems to respond.
- You would even so not get p.acnes colonisation of the hair follicle duct without having a plug forming.
- The plug types due to an enhance in skin cell turnover, improved keratin deposition narrowing the opening of the hair follicle duct, combined with elevated sebum production, which mixes with the debris to result in a blockage and a plug to type.
- The improved sebum, keratin and cell turnover would not take place if linoleic acid levels in the skin had reduced dramatically.
- Linoleic acid levels lowered due to the development of sensitivity to the hormone DHT.
- DHT is formed from testosterone. The chemical reaction naturally takes place all through the physique and the conversion of testosterone to DHT is assisted and promoted by the enzyme named five-alpha reductase. (All chemical reactions in the body are controlled and accelerated by enzymes).
Possible options to the underlying causes of acne:
1) Cease hormonal fluctuations. This is impossible although individuals do try by taking plant hormones, HRT and royal jelly. But essentially it is very best not to mess with our natural hormonal balance.
2) Use Roaccutane. This will affect the conversion of testosterone to DHT, but this will occur all over the physique and DHT plays a function in a number of body functions and suppressing it leads to a number of achievable side effects.
3) Reduce DHT levels in the hair follicle and in sebaceous gland region only, recognized as the pilo-sebaceous unit. If it were feasible to avoid testosterone from converting to DHT in the acne region of the skin but not stopping this conversion elsewhere in the body could reduce skin sensitisation and the resulting linoleic acid loss, but with out affecting the conversion of testosterone to DHT in other parts of the physique. Learn further on fat burner by browsing our tasteful encyclopedia. This would be wonderful in principle if a single can alter the situations in the pilosebaceous unit for an extended period of time so that DHT levels were reduced locally for the duration of the times in our lives when typical hormone levels had been out of sync with a topical preparation could lead to a reduction in the triggering of the acne process. Two merchandise known as tri-ethyl citrate and ethyl linoleate which are protected and release citric acid and linoleic acid can change conditions in the skin which slows down the enzyme 5-alpha reductase and hence testosterone conversion to DHT is slowed down locally. The testosterone conversion to DHT will nonetheless happen but just somewhere else in the body, which means other bodily processes are not impacted.
four) If one particular could also replenish linoleic acid levels in the skin then this would lead to a slow down in oil production and skin cell turnover rates and keratin deposition, stopping the plug forming and the colonisation by p.acnes.
five) A single could take linoleic acid supplements and foods high in linoleic acid. Nevertheless linoleic acid is employed by several parts of the physique and 1 would have to take possibly toxic levels to have an effect on skin levels drastically sufficient via oral supplementation alone. Doing this without having going to excess is most likely even so a great issue and it has been noticed that the Eskimos (the Inuit) did not suffer from acne until they have been introduced to western diets. Even so if a single can locate a way to supplement skin linoleic acid levels employing a topical preparation then this would also have an effect on the acne approach.
six) Receiving linoleic acid into the skin is not effortless but you can use specific delivery technology employing special molecular structures in creams such as Oleosomes and involving techniques with fancy names such as Drysyst technology to support this method. Also if a single makes use of ethyl linoleate, then skin bacteria will help break this down and release linoleic acid into the skin (appear for items containing ethyl linoleate.)
7) 1 could normalise cell turnover to reduce skin thickening and also lessen keratin increases in skin cells. This would aid to avoid blocking of the pilo-sebaceous duct. Identify further on oleic acid by navigating to our lovely paper. Retinol A based creams have been shown to normalise skin cell turnover prices. Even so a possible side impact of retinol items is elevated sensitivity to UV and possibly increased skin cancer threat. So customers of retinol based items are advised strongly to use a high SPF sunscreen although utilizing retinol primarily based products. There is a chemical named triethyl citrate which also normalises keratin deposition and skin cell turnover prices and with out causing photo-sensitivity (please search for merchandise containing triethyl citrate).
8) Reduce oil levels on the skin. This is generally carried out by employing detergents to keep surface oil levels down. Undertaking this on its personal just leads to a lot more oil production and one gets into a downward spiral with a unfavorable feedback loop major to additional increase (up regulation) of sebum (oil) production. Nevertheless oil control is essential and making use of mild detergents can help in controlling the acne approach. Going To fat burning powder maybe provides suggestions you could use with your co-worker. Utilizing a mixture of triethyl citrate and ethyl linoleate has been shown in a clinical trial published in the British Journal of Dermatology at the end of 2007 which showed sebum production prices reduced by up to 68% with an typical of 55%.
9) Use exfoliants and detergents to support unblock ducts by dissolving and removing plugs and keeping skin debris levels down and also reducing skin thickening. This is efficient and can help but if the skin is inflamed and sore then exfoliants can, make the skin a lot more sensitive and sore. It possibly better to use chemical exfoliants rather than irritating physical skin exfoliants. Far better nonetheless use those which have shown to have an effect on sebum production prices such as Salicylic acid and Pyruvic acid which are both hydroxy acids (also known as fruit acids). These are the only two who have shown a sebo-static effect which means temporarily slowing oil production. One more typical chemical exfoliant used is glycolic acid but this has not shown to have a sebo-static effect. Also salicylic acid has shown to support with skin thickening by loosening skin cells. See products containing Salicylic acid and Pyruvic acid).
ten) Even goods with fruit acids may irritate some skins, and some acne sufferers such as younger skins can be extremely sensitive and truly dont have excessive skin thickening. One particular could use a gentle non irritating cleansing agent containing goods such as silicone and glucose primarily based cleansers which are very skin friendly, and also include triethyl citrate which will normalise skin thickening by addressing more than active skin cell turnover, thereby addressing skin thickening from inside the skin.
11) Handle p.acnes levels. Keeping hair follicle ducts open and oxygen rich is one way but blockages can nevertheless happen. So if you are going to control p.acnes than ideally do this with no attacking skin staphylococci as discussed earlier due to MRSA improvement risks. One particular can use antibiotics to do this and they might be indicated in pustular scarring acne but for most we know that p.acnes releases enzymes to break down the plug to release nutritious fatty acids which also can result in an inflammatory response from the physique. If you adjust situations in the pilosebaceous unit so these enzymes dont operate as properly you can slow down this method and lessen the amount of food and consequently reduce the growth of p.acnes without having attacking very good skin bacteria (staphs) (see an instance of how this ca be achieved)
12) Lessen inflammation. Making use of products to handle bacteria will lessen inflammation but also anti-inflammatorys employed to reduce inflammation. Stopping the release of the inflammatory fatty acids is one more way, but also mopping up the inflammatory free of charge radicals produced is an added way of controlling inflammation. Antioxidants are useful in this regard and the best antioxidants are possibly skin soluble version of vitamin C such as ascorbic acid and other people such as Ascorbyl Palmitate and particularly Ascorbyl tetra-isopalmitate (see an example of a item containing these).
In Summary
If you have a solution range which alters circumstances to slow DHT production locally, improve linoleic acid levels in the skin, that normalise skin cell turnover, keratin deposits and sebum production even though also having mild sebo static chemical exfoliants or silicone and glucose based cleansers. If this product also had, staph friendly antibacterials to control p.acnes, feeding and improvement combined with antioxidants to assist control the inflammatory approach, then you would have a extremely powerful product range which could be obtained with or without prescription and is supported by eminent dermatologists across the planet, including the top dermatologist on acne in the UK who has had his independent trail published din the most respected dermatology journal in the planet, then you would be onto a winner. If this solution was extremely reasonably priced you would consider it would dominate the remedy choices of acne.