"We tend to think of protists (single-celled organisms) as 'simple' and humans as 'complex' -- but the Naegleria genome shows us that much of this complexity arose really early in evolution," said Scott Dawson, assistant professor of microbiology at UC Davis.
Dawson is senior author on the paper analyzing the genome of Naegleria gruberi, published in the March issue of the journal Cell. The team also included UC Davis graduate students Michael Cipriano and Jonathan Pham. Dawson had initially proposed N. gruberi as a candidate for genome sequencing back in 2004 while he was a postdoctoral researcher at UC Berkeley.
N. gruberi slurps around in mud as an amoeba but when food runs low it sprouts two whip-like tails, or flagellae, and swims rapidly away. It can also transform into a hard, resistant cyst to wait out bad conditions.
Most previous efforts to sequence the genomes of protozoa have focused on parasitic organisms such as the malaria parasite.
"Because it's free living, it can tell us a lot about early life -- it has genes to do all these different things," Dawson said.
The analysis shows that N. gruberi has 15,727 genes that code for proteins, compared to about 23,000 in humans. With those genes, the organism can eat and reproduce, crawl or swim, live with or without oxygen, and organize itself internally much as a human cell does.
