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Vitamin D, nervous system and aging.\nP. Tuohimaa, T. Keisala, A. Minasyan, J. Cachat and A. Kalueff. .\nPsychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286\n NEUROACTIVE STEROIDS: EFFECTS and MECHANISMS ofACTION\n \n\nReview of vitamin D3, its active metabolites, and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis, and muscle weakness ~ all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimers, Parkinsons, seasonal affective disorder (SAD), and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. * Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS. *

"According to a small German study published in the New England Journal of Medicine (NEJM), researchers found that DHEA improved sexuality and well-being in 24 women diagnosed with adrenal insufficiency. The double-blind study found that women who took 50 mg of DHEA daily reported significant increases in how often they thought about sex, how interested they were in sexual activity, and their levels of both mental and physical sexual satisfaction. These women also reported improvement in mental health issues such as obsessive-compulsive traits, depression, anxiety, and other psychological conditions. The most significant improvements were seen four months after treatment began. "

Endocrinological associations with prothrombotic disorders