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"Lancet 2010: There is a U-shaped relationship between glycated hemoglobin (HbA1c) levels and mortality in people with diabetes, say researchers, meaning that intensive glucose-lowering therapy could be as harmful as uncontrolled hyperglycemia.\n\nWriting in The Lancet, Craig Currie and team (Cardiff University, UK) conclude that if their findings are confirmed, then diabetes guidelines may need to be revised to include a lower as well as an upper HbA1c threshold.\n\nCurrie's team used the UK General Practice Research Database from November 1986 to November 2008 to obtain data on two cohorts of patients aged 50 years and older with Type 2 diabetes.\n\nThe patients comprised 27,965 individuals whose treatment had been intensified from oral monotherapy to combination therapy with oral blood-glucose lowering agents, and 20,005 who had changed to insulin-containing regimens."

Takashi Kadowaki and colleagues at the University of Tokyo administered adiponectin to obese mice fed a high fat diet & to mice w/reduced levels of body fat, improving insulin resistance & lowering blood glucose levels in both sets of mice.

Hypercoagulation in diabetes; intensive treatment of glycemia and the procoagulant state.

Polysaccharides, a type of carbohydrate that includes starch and cellulose, may benefit people with diabetes because they help retard absorption of glucose.

Resveratol, found in red wine (etc.) stimulates the SIRT1 gene, which is linked to extended health + lifespan in rodents. Sitris was able to replicate those results in humans. The resveratol formula stimulates the same gene that 'calorie-restricted' diets do. Sitris also found it reduces blood glucose in diabetic patients...But small trial, short duration...