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Fco Javier Casas Ciria

Ahead of Print -Delivering on Antimicrobial Resistance Agenda Not Possible without Impr... - 0 views

    • Fco Javier Casas Ciria
       
      Candidiasis invasiva asociada a previa infección bacteriana y previa tratamiento antibacteriano, con inapropiada combinacióna antibiótica
  • 81% were exposed to multiple antibacterial drugs, either concomitantly or sequentially
  • Early therapy of Candida spp. bloodstream infection greatly improves patient outcomes and the outcome is even better if correct therapy is given immediately
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  • Once Candida-associated sepsis is confirmed, antibacterial agents can usually be stopped and, if Candida sepsis is ruled out, empiric antifungal therapy can be stopped.
  • for ruling out a diagnosis of invasive candidiasis,
  • the 1,3 β-D-glucan assay
  • Candida albicans germ tube antibody test, which is used with serum samples
  • and a nonculture-based molecular assay
  • Overuse of antifungal agents is costly, can promote antifungal resistance, and has the potential for causing toxicity and various detrimental drug interactions in patients
anonymous

Interactive iPhone app helps providers simulate cardiac arrest cases - 0 views

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    "CPR game allows an individual to practice a simulated cardiac arrest scenario on an iPhone. The game is won by completing all "critical actions" in a timely manner and avoiding any harmful actions."
anonymous

Exploring Curation as a core competency in digital and media literacy education | Mihai... - 1 views

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    The six teaching points above collectively approach a framework that includes curation as a core media literacy competence for the digital generation
anonymous

Finding the right interactional temperature: Do colder patients need more warmth in phy... - 0 views

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    "Being aware of which communication style should be adopted when facing more difficult patients is important for physicians; it can help prevent patient reactions of dissatisfaction, mistrust, or non-adherence that can be detrimental to the process of care."
Dianne Rees

Health Reform Resource - The Commonwealth Fund - 0 views

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    Interactive timeline shows when various provisions of the Affordable Care Act take effect
anonymous

Understanding Medical Words - 4 views

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    An interactive tool from NIH for learning and understanding medical terminology
Natalie Lafferty

Interacting with the Medical Humanities - 0 views

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    A site of Georgetown University which looks at patient' experiences expressed through theatre, dance and poetry.
Anne Marie Cunningham

Patient engagement - The Health Foundation - 0 views

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    How can we support patient self-management?
anonymous

headache.interactive(home-page) - 0 views

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    A site about communicating with and diagnosing patients with headaches.
anonymous

JeopardyLabs - Online Jeopardy Template - 2 views

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    JeopardyLabs allows you to create a customized jeopardy template without PowerPoint. The games you make can be played online from anywhere in the world. Building your own jeopardy template is a piece of cake. Just use our simple editor to get your game up and running.
Ambika Kilaparthi

Placebos Are Getting More Effective. Drugmakers Are Desperate to Know Why. - 0 views

  • response to placebo was considered a psychological trait related to neurosis and gullibility rather than a physiological phenomenon that could be scrutinized in the lab and manipulated for therapeutic benefit. But then Benedetti came across a study, done years earlier, that suggested the placebo effect had a neurological foundation. US scientists had found that a drug called naloxone blocks the pain-relieving power of placebo treatments. The brain produces its own analgesic compounds called opioids, released under conditions of stress, and naloxone blocks the action of these natural painkillers and their synthetic analogs.
  • Placebo-activated opioids, for example, not only relieve pain; they also modulate heart rate and respiration. The neurotransmitter dopamine, when released by placebo treatment, helps improve motor function in Parkinson's patients. Mechanisms like these can elevate mood, sharpen cognitive ability, alleviate digestive disorders, relieve insomnia, and limit the secretion of stress-related hormones like insulin and cortisol.
  • Alzheimer's patients with impaired cognitive function get less pain relief from analgesic drugs than normal volunteers do. Using advanced methods of EEG analysis, he discovered that the connections between the patients' prefrontal lobes and their opioid systems had been damaged. Healthy volunteers feel the benefit of medication plus a placebo boost. Patients who are unable to formulate ideas about the future because of cortical deficits, however, feel only the effect of the drug itself. The experiment suggests that because Alzheimer's patients don't get the benefits of anticipating the treatment, they require higher doses of painkillers to experience normal levels of relief.
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  • placebo response has limits. It can ease the discomfort of chemotherapy, but it won't stop the growth of tumors. It also works in reverse to produce the placebo's evil twin, the nocebo effect. For example, men taking a commonly prescribed prostate drug who were informed that the medication may cause sexual dysfunction were twice as likely to become impotent.
  • placebo aids recovery is by hacking the mind's ability to predict the future. We are constantly parsing the reactions of those around us—such as the tone a doctor uses to deliver a diagnosis—to generate more-accurate estimations of our fate. One of the most powerful placebogenic triggers is watching someone else experience the benefits of an alleged drug. Researchers call these social aspects of medicine the therapeutic ritual.
  • What turns a dummy pill into a catalyst for relieving pain, anxiety, depression, sexual dysfunction, or the tremors of Parkinson's disease? The brain's own healing mechanisms, unleashed by the belief that a phony medication is the real thing. The most important ingredient in any placebo is the doctor's bedside manner, but according to research, the color of a tablet can boost the effectiveness even of genuine meds—or help convince a patient that a placebo is a potent remedy.
  • Red pills can give you a more stimulating kick
  • green reduces anxiety
  • White tablets—particularly those labeled "antacid"—are superior for soothing ulcers
  • More is better,scientists say. Placebos taken four times a day deliver greater
  • Branding matters. Placebos stamped or packaged with widely recognized trademarks are more effective than "generic"
  • Clever names
  • volunteers in this high-interaction group got as much relief as did people taking the two leading prescription drugs for IBS. And the benefits of their bogus treatment persisted for weeks afterward, contrary to the belief—widespread in the pharmaceutical industry—that the placebo response is short-lived.
  • hybrid treatment strategies that exploit the placebo effect to make real drugs safer and more effective. Cancer patients undergoing rounds of chemotherapy often suffer from debilitating nocebo effects—such as anticipatory nausea—conditioned by their past experiences with the drugs. A team of German researchers has shown that these associations can be unlearned through the administration of placebo, making chemo easier to bear.
  • body's response to certain types of medication is in constant flux, affected by expectations of treatment, conditioning, beliefs, and social cues.
  • Big Pharma have moved aggressively into Africa, India, China, and the former Soviet Union. In these places, however, cultural dynamics can boost the placebo response in other ways. Doctors in these countries are paid to fill up trial rosters quickly, which may motivate them to recruit patients with milder forms of illness that yield more readily to placebo treatment. Furthermore, a patient's hope of getting better and expectation of expert care—the primary placebo triggers in the brain—are particularly acute in societies where volunteers are clamoring to gain access to the most basic forms of medicine. "The quality of care that placebo patients get in trials is far superior to the best insurance you get in America
  • The HAM-D was created nearly 50 years ago based on a study of major depressive disorder in patients confined to asylums. Few trial volunteers now suffer from that level of illness. In fact, many experts are starting to wonder if what drug companies now call depression is even the same disease that the HAM-D was designed to diagnose.
  • What all of these disorders have in common, however, is that they engage the higher cortical centers that generate beliefs and expectations, interpret social cues, and anticipate rewards. So do chronic pain, sexual dysfunction, Parkinson's
  • In standard trials, the act of taking a pill or receiving an injection activates the placebo response. In open/hidden trials, drugs and placebos are given to some test subjects in the usual way and to others at random intervals through an IV line controlled by a concealed computer. Drugs that work only when the patient knows they're being administered are placebos themselves.
  • Ironically, Big Pharma's attempt to dominate the central nervous system has ended up revealing how powerful the brain really is. The placebo response doesn't care if the catalyst for healing is a triumph of pharmacology, a compassionate therapist, or a syringe of salt water. All it requires is a reasonable expectation of getting better. That's potent medicine.
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