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"Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People"

I heard Trojanowski (the senior author) talk about this last month at the annual meeting of the American Association for Clinical Chemistry. It's a very interesting topic with a lot of social ramifications. The statement in the absrract that among people with mild cognitive impairment, the biomarker profile had a 100% sensitivity for development of AD needs to be carefully considered. First, the metric that is of greater interest is the positive predictive value. Second, it is known that some patients who have the classic AD findings at autopsy did not have mental impairment in life. We know this from the Nun study.