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anonymous

Gaming the System: Video Gamers Help Researchers Untangle Protein Folding Problem: Scientific American - 0 views

  • What if the brainpower used playing video games could be channeled toward something more productive, such as helping scientists solve complex biological problems?
  • Their competitive online game "Foldit," released in 2008, enlists the help of online puzzle-solvers to help crack one of science's most intractable mysteries—how proteins fold into their complex three-dimensional forms. The "puzzles" gamers solve are 3-D representations of partially folded proteins, which players manipulate and reshape to achieve the greatest number of points. The scores are based on biochemical measures of how well the players' final structure matches the way the protein appears in nature.
  • The scientists hope to incorporate the newly identified strategies into computer algorithms for improved automated determinations of protein structure. The ultimate hope is to use these techniques to design new proteins to fight diseases such as Alzheimer's and cancer as well as develop vaccines against HIV and malaria.
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    "The combined effort of more than 50,000 online video game players may help scientists better understand how proteins fold, solving one of biochemistry's greatest conundrums." By Nicholette Zeliadt at Scientific American on August 4, 2010.
anonymous

Nearly 1 million children potentially misdiagnosed with ADHD, study finds - 0 views

  • These children are significantly more likely than their older classmates to be prescribed behavior-modifying stimulants such as Ritalin, said Todd Elder, whose study will appear in a forthcoming issue of the Journal of Health Economics.
  • Such inappropriate treatment is particularly worrisome because of the unknown impacts of long-term stimulant use on children's health, Elder said.
  • Elder said the "smoking gun" of the study is that ADHD diagnoses depend on a child's age relative to classmates and the teacher's perceptions of whether the child has symptoms.
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  • The results – both from individual states and when compared across states – were definitive. For instance, in Michigan – where the kindergarten cutoff date is Dec. 1 – students born Dec. 1 had much higher rates of ADHD than children born Dec. 2. (The students born Dec. 1 were the youngest in their grade; the students born Dec. 2 enrolled a year later and were the oldest in their grade.) Thus, even though the students were a single day apart in age, they were assessed differently simply because they were compared against classmates of a different age set, Elder said.
    • anonymous
       
      This is reminicient of Malcolm Gladwell's date-based categorization that create's false results.
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    "Nearly 1 million children in the United States are potentially misdiagnosed with attention deficit hyperactivity disorder simply because they are the youngest - and most immature - in their kindergarten class, according to new research by a Michigan State University economist." At Lab Spaces on August 17, 2010.
anonymous

Objectivism & "Metaphysics," Part 14 - 0 views

  • Exhibit 1:I was astonished at how closed she typically was to any new knowledge [testifies Nathaniel Branden] .…When I tried to tell her of some new research that suggested that certain kinds of depression have a biological basis, she answered angrily, ‘I can tell you what causes depression; I can tell you about rational depression and I can tell you about irrational depression—the second is mostly self-pity—and in neither case does biology enter into it.’ I asked her how she could make a scientific statement with such certainty, since she had never studied the field; she shrugged bitterly and snapped, ‘Because I know how to think.’” (Judgement Day, 1989, 347)
  • Rand is claiming because people have free will, they cannot possibly be influenced by biological factors. But this is merely an a priori rationalization of the worst sort. Claims about the biological basis of an emotion can only be settled experimentally, through empirical testing. The evidence for the hypothesis that biological factors can influence emotions is overwhelming and not in dispute among psychiatrists familiar with the relevant research. If anyone has any doubt on the score, just consider how diseases of the brain can affect emotion and personality.
  • So how exactly does evolutionary psychology explain the misery, the jealousy, the lying [that occurred as a result of Rand’s affair with Nathaniel Branden]? When Rand and her followers tried to wish away obvious facts about humans' emotional constitution, their feelings didn't change. But they made each other miserable pretending that they felt the way they were supposed to feel. Rand and Nathaniel had to pretend that Nathaniel was attracted to Rand. Their spouses had to pretend that they weren't jealous. Rand and Nathaniel had to pretend that they believed that their spouses weren't jealous. The more they tried to talk themselves into having feelings contrary to human nature, the worse they felt. Nathaniel coped not by admitting error, but by finding a mistress and lying to cover it up. Since Rand had already ruled out the obvious explanation for Nathaniel's behavior, she went on a wild goose chase to find the "real" explanation. Etc...
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  • Human beings evolved in small groups where good relations were vital for survival. People who weren't interested in other people's opinions had trouble staying alive and reproducing. Caring about the opinions of others isn't as immutable as our sexual preferences, but it's very deeply rooted.
  • To deny a human nature consisting of innate propensities is a far more serious matter than denying facts about quantum mechanics or Einstienian relativity.
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    "Where the Objectivist metaphysics seriously leads its partisans astray is on the issue of free will and human nature. For Rand, free will is axiomatic, which means, "self-evident" and "fundamentally given and directly perceived." Now whether free will is self-evident I will leave for another post. Here I'm only interested in specific facts that are sacrificed on the alter of Rand's free will." By Greg Nyquist at Ayn Rand Contra Human Nature on October 5, 2010.
anonymous

Think You Know How To Study? Think Again : NPR - 0 views

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    "Find a quiet location. Keep a routine. Focus on one subject at a time. It all seems like sound advice for students who need to hit the books, but recent studies indicate the conventional wisdom is all wrong. New York Times reporter Benedict Carey has written about the research. He tells NPR's Neal Conan that though a lot of ideas about learning make intuitive sense, they're actually way off." At Talk of the Nation at NPR on October 25, 2010.
anonymous

The Least You Should Know - 0 views

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    "If you live in the United States, you probably have an opinion on the best way to reduce the deficit. And you probably know almost nothing about the topic. I certainly fall into that category. If you listen to pundits and politicians, you're getting your information from professional liars. If you're reading books, you're getting your information from professional liars who also write well. If you read newspapers and magazines, you're getting only the information that someone has decided will be good for sales. If you say you "do your own research," you're probably a liar, possibly an idiot, and maybe some sort of analytical genius. And frankly, I can't tell you guys apart." By Scott Adams at his blog on November 8, 2010.
anonymous

Supercomputers 'will fit in a sugar cube,' IBM says - 0 views

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    "A pioneering research effort could shrink the world's most powerful supercomputer processors to the size of a sugar cube, IBM scientists say. The approach will see many computer processors stacked on top of one another, cooling them with water flowing between each one." At Kurzweil, but by BBC News on November 12, 2010.
anonymous

Gamifying Homework - 0 views

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    "If the success of sites like Gowalla, Foursquare, and other game-like forms of social media tells us much, it's that people will do *anything* for a virtual badge. The attempt to capitalize on this behavior has been called gamification, since it borrows some of the reward structures of game mechanics and applies them to everyday tasks. While the premise behind it has been around for a while, as Wikipedia notes, it has started to get more attention from venture capitalists, developers, and researchers in 2010." By Jason B. Jones at The Chronicle on November 3, 2010.
anonymous

Why Most Published Research Findings are False - 0 views

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    "Suppose there are 1000 possible hypotheses to be tested. There are an infinite number of false hypotheses about the world and only a finite number of true hypotheses so we should expect that most hypotheses are false. Let us assume that of every 1000 hypotheses 200 are true and 800 false. It is inevitable in a statistical study that some false hypotheses are accepted as true. In fact, standard statistical practice guarantees that at least 5% of false hypotheses are accepted as true. Thus, out of the 800 false hypotheses 40 will be accepted as "true," i.e. statistically significant." By Alex Tabarrok at Marginal Revolution on September 2, 2005.
anonymous

Study: Today's youth aren't ego-driven slackers after all - 0 views

  • Today's youth are generally not the self-centered, antisocial slackers that previous research has made them out to be, according to a provocative new study co-authored by a Michigan State University psychologist.
  • -Today's youth are more cynical and less trusting of institutions than previous generations. But Donnellan said this is generally true of the broader population. -The current generation is less fearful of social problems such as race relations, hunger, poverty and energy shortages. -Today's youth have higher educational expectations.
  • "Kids today are like they were 30 years ago – they're trying to find their place in the world, they're trying to carve out an identity, and it can be difficult," Donnellan said. "But lots of research shows that the stereotypes of all groups are much more overdrawn than the reality."
anonymous

Decades of research show massive Arctic ice cap is shrinking - 0 views

  • Close to 50 years of data show the Devon Island ice cap, one of the largest ice masses in the Canadian High Arctic, is thinning and shrinking.
  • The work of Boon and her colleagues demonstrates the importance of long-term research.
  • "We all know long-term studies are important but they are really hard to pay for."
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    From Lab Spaces on April 12, 2010.
anonymous

Health care reform: A simple explanation, updated - 0 views

  • The Senate bill does not require employers to offer insurance, but it does impose taxes on employers if they don't offer insurance and their employees qualify for new health insurance tax credits.
  • regulate the exchanges so that insurance companies couldn't discriminate against people with pre-existing conditions, or charge wildly different amounts for similar coverage.
  • Insurers would have to cover preventive care, and they wouldn't be able to cut off coverage unfairly or set annual limits on benefits.
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  • expands eligibility for insurance programs like Medicaid and the state Children's Health Insurance Program. All poor people would qualify for Medicaid.
  • People who don't buy insurance would have to pay a penalty on their taxes. Under the Senate bill, the share of legal nonelderly residents with insurance coverage is expected to rise from about 83 percent currently to about 94 percent.
  • promote standardized electronic health records
  • A comparative effectiveness research center would conduct and publish scientific research to find which treatments are the most effective.
  • the new rules aim to pay doctors for good patient outcomes instead of paying them per procedure, also called "fee-for-service."
  • For the large group market, the CBO found that rates would either stay the same or decline slightly. For the small group market, rates would essentially stay the same as well. The individual market is a more complicated story
  • Covering millions of people who are now uninsured would cost billions more per year.
  • Critics say the Democratic plans would lead to health care rationing.
  • The public option is an insurance plan run by the government that individuals can choose over private insurance.
  • The more generous the benefits, the higher the costs.
  • The House measure put more restrictions on how insurers could offer coverage for abortion services.
  • the CBO warns that it's very difficult to put dollar figures on many of these things, because of the size of the health care industry and the inherent unpredictability of major policy changes over many years.
  • It's good to keep in mind that when it comes to health care reform, no one has a crystal ball.
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    From Politifact. A basic explanation.
anonymous

Middle school is when the right friends may matter most - 1 views

  • Having pro-social friends and staying away from deviant peers proved more effective for academic payoffs than simply being friends with high-achieving peers.
    • anonymous
       
      Duh? Certainly with regard to academics, there are no surprises here, but it's interesting that improvement is correlated with avoidance-of problem kids not hanging-with high achievers.
  • This new study -- conducted by Marie-Helene Veronneau and Thomas J. Dishion of the UO Child and Family Center -- focused solely on the role played by friendship on academic achievement.
    • anonymous
       
      And, like every damned study, take this with a giant grain of salt. Maybe, snowball sized.
  • A surprise discovery was that girls who already were struggling academically in sixth grade actually suffered later when their chosen friends were already those making the highest grades, Veronneau said. "We don't know the mechanisms on why it is this way for girls, but we can speculate that girls compare themselves to their friends and then decide they are not doing very well. Perhaps this affects their self-efficacy and belief in their own abilities."
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  • For girls already doing well in sixth grade, however, there was an opposite influence. "It could be for these girls, having friends who also are getting good grades, school is challenging and stimulating, and they end up doing better than expected," she said.
    • anonymous
       
      These two examples strike me as a kind of slope. Whichever side of the slope you find yourself on sort of reinforces itself.
  • "Puberty is taking place. The brain is changing rapidly. Kids' brains are almost wired to be reading the social world to see how they fit in, and the school is the arena for it."
  • In a previous longitudinal study, he said, he and colleagues looked at the impacts of peer relationships of young people at ages 13, 15 and 17 to look for predictive indicators of life adjustments at age 24. Those influences at age 13 -- going back to middle school -- were the most influential, he noted. While instruction is school is vitally important, he said, it may be that more eyes should be looking at shifting peer relationships.
  • "Parents should pay attention to what their kids are doing and with whom they hang out," Veronneau said. "If parents notice that there is a shift in a child's friendship network, they should try to get to know those kids, talk with teachers and communicate naturally with their own child about where they are going and when they will be coming home."
    • anonymous
       
      This is a classic difference of broad generational differences in how children are raised. It's helicopter-ish, but I sure get it.
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    "As adolescents move from elementary school into their middle or junior-high years, changes in friendships may signal potential academic success or troubles down the road, say University of Oregon researchers."
anonymous

The "1-10-100 Principle" for experimenters - 0 views

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    "Peter Tu of GE Global Research went to Maker Faire in San Mateo in May and wrote a piece about what he witnessed there. Like many others, he was impressed with Stephen Voltz and Fritz Grobe's talk about the "1-10-100 Principle" for experimenters. "
anonymous

Images capture moment brain goes unconscious - 0 views

  • As the patient goes under, different parts of the brain seem to be "talking" to each other, a team told the European Anaesthesiology Congress in Amsterdam.
  • they caution that more work is needed to understand what is going on.
  • unconsciousness is a process by which different areas of the brain inhibit each other as the brain shuts down.
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    "For the first time researchers have monitored the brain as it slips into unconsciousness. The new imaging method detects the waxing and waning of electrical activity in the brain moments after an anaesthetic injection is administered."
anonymous

Libertarianism and Hegemony - 0 views

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    The comments are a hoot. "My views on foreign policy tend to diverge from mainstream libertarian doctrine. Take American hegemony. Many people are predicting (usually with glee) the demise of American power (see, for example, Ronald Dworkin). Regardless of the accuracy of these predictions, I think libertarians have reasons to support American global hegemony. Realistic alternatives to hegemony are the international state of nature, balance of power, and governance by an international institution such as the United Nations. The state of nature is undesirable for well-known Hobbesian reasons: defensive efforts would undermine productive cooperation. Balance of power is inherently unstable; sooner or later will morph into hegemonic power. And, at least in today's world, governance by an international institution would be plagued by legitimacy deficits and agency costs that would surely threaten liberal values. So, if we are going to have hegemony as the only arrangement capable of providing global public goods, the United States is the least bad because American institutions and culture embody liberal values. Any likely competitor is certainly to be worse for those who cherish liberal values. I believe history supports this, too: three times during the 20th century the United States saved liberal culture from onslaughts by illiberal forces. Objections to hegemony are often condemnations of means rather than ends, and I certainly agree with those where applicable. Let us concede that the United States sometimes pursues moral ends (say, helping other nations achieve freedom) with immoral means (say, bringing about unjustified collateral harm). Citizens in liberal democracies must oppose the use of immoral means, even for a good cause. However, this kind of criticism cannot be a wholesale condemnation of hegemony, because there are world powers, such as the Soviet Union, who pursue immoral ends. Surely these cannot be saved even when they use moral means (whi
anonymous

Three arguments against the singularity - 1 views

  • economic libertarianism is based on the same reductionist view of human beings as rational economic actors as 19th century classical economics — a drastic over-simplification of human behaviour. Like Communism, Libertarianism is a superficially comprehensive theory of human behaviour that is based on flawed axioms and, if acted upon, would result in either failure or a hellishly unpleasant state of post-industrial feudalism.
  • I am not an extropian
  • I'm definitely not a libertarian:
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  • super-intelligent AI is unlikely because, if you pursue Vernor's program, you get there incrementally by way of human-equivalent AI, and human-equivalent AI is unlikely. The reason it's unlikely is that human intelligence is an emergent phenomenon of human physiology, and it only survived the filtering effect of evolution by enhancing human survival fitness in some way.
    • anonymous
       
      In other words: what we call 'consciousness' is a bundle of physiological responses, not some tightly designed status.
  • it's possible that just as destructive research on human embryos is tightly regulated and restricted, we may find it socially desirable to restrict destructive research on borderline autonomous intelligences ... lest we inadvertently open the door to inhumane uses of human beings as well.
  • whether we want them to be conscious and volitional is another question entirely. I don't want my self-driving car to argue with me about where we want to go today. I don't want my robot housekeeper to spend all its time in front of the TV watching contact sports or music videos. And I certainly don't want to be sued for maintenance by an abandoned software development project.
  • Consciousness seems to be a mechanism for recursively modeling internal states within a body.
  • Uploading ... is not obviously impossible unless you are a crude mind/body dualist. However, if it becomes plausible in the near future we can expect extensive theological arguments over it. If you thought the abortion debate was heated, wait until you have people trying to become immortal via the wire.
  • Our form of conscious intelligence emerged from our evolutionary heritage, which in turn was shaped by our biological environment. We are not evolved for existence as disembodied intelligences, as "brains in a vat", and we ignore E. O. Wilson's Biophilia Hypothesis at our peril
  • Moving on to the Simulation Argument: I can't disprove that, either. And it has a deeper-than-superficial appeal, insofar as it offers a deity-free afterlife, as long as the ethical issues involved in creating ancestor simulations are ignored.
  • This is my take on the singularity: we're not going to see a hard take-off, or a slow take-off, or any kind of AI-mediated exponential outburst. What we're going to see is increasingly solicitous machines defining our environment — machines that sense and respond to our needs "intelligently". But it will be the intelligence of the serving hand rather than the commanding brain, and we're only at risk of disaster if we harbour self-destructive impulses.
  • We may eventually see mind uploading, but there'll be a holy war to end holy wars before it becomes widespread: it will literally overturn religions.
  • our hard-wired biophilia will keep dragging us back to the real world, or to simulations indistinguishable from it.
  • Therefore I conclude that, while not ruling them out, it's unwise to live on the assumption that they're coming down the pipeline within my lifetime.
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    Over at Charlie's Diary, Mr. Stross articulates why he's not super-enamored of the Singularity. He begins: "I periodically get email from folks who, having read "Accelerando", assume I am some kind of fire-breathing extropian zealot who believes in the imminence of the singularity, the uploading of the libertarians, and the rapture of the nerds. I find this mildly distressing, and so I think it's time to set the record straight and say what I really think. Short version: Santa Claus doesn't exist." The Long version commences...here are excerpts.
anonymous

A single mutant gene is responsible for 30% of all mysterious pain - 0 views

  • Yale researchers, working with colleagues in the Netherlands, found that this particular gene is responsible for the horrifically named "Man on Fire Syndrome", a rare disorder marked by pain so severe that it's like...well, I think you can probably guess what it's like.
  • What's more, when the researchers examined 28 patients with peripheral neuropathy that could not otherwise be explained, 30% of the patients showed mutations in the SCNA9.
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    "In the United States alone, 20 million people suffer from peripheral neuropathy, a condition that involves nerve degeneration and sometimes extreme pain, often without any explanation. Now we've found the culprit for this mysterious pain...and it's all one gene's fault. "
anonymous

Study of the Day: As It Happens, the Gen-Xers Turned Out All Right - 2 views

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    New research from the University of Michigan shows that most members of Generation X are happy, active, and not full of angst.
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    So quit whining and try to make a positive difference, already! Sincerely, The Oldest Gen Y
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    Damn straight.
anonymous

10 Pro-Gun Myths, Shot Down - 0 views

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    "By cutting off federal funding for research and stymieing data collection and sharing, the National Rifle Association has tried to do to the study of gun violence what climate deniers have done to the science of global warming. No wonder: When it comes to hard numbers, some of the gun lobby's favorite arguments are full of holes."
anonymous

The Paradox of America's Electoral Reform - 0 views

  • This election process matters to the world for two reasons.
  • First, the world's only global power will be increasingly self-absorbed
  • The United States sees itself as the City on the Hill, an example to the world. But along with any redemptive sensibility comes its counterpart: the apocalyptic.
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  • Likely an archaic institution, the Electoral College still represents the founders' fear of the passions of the people — both the intensity of some, and the indifference of others.
  • They had two visions: that representatives would make the law, and that these representatives would not have politics as a profession.
  • The founders saw civil society — business, farms, churches and so on — as ultimately more important than the state, and they saw excessive political passion as misplaced.
  • First, it took away from the private pursuits they so valued, and it tended to make political life more important than it should be.
  • Second, they feared that ordinary men (women were excluded) might be elected as representatives at various levels.
  • They tried to shape representative democracy with standards they considered prudent — paralleling the values of their own social class, where private pursuits predominated and public affairs were a burdensome duty.
  • Of course it was the founders who created political parties soon after the founding. The property requirements dissolved fairly quickly, the idea that state houses would elect senators went away, and the ideological passions and love of scandal emerged. 
  • Political parties were organized state by state, and within state by counties and cities. These parties emerged with two roles.
  • The first was to generate and offer potential leaders for election at all levels.
  • The second was to serve as a means of mediation between the public — for multiple classes, from the wealthy to the poor — and the state.
  • The party bosses did not have visions of redemption or apocalypse. They were what the founders didn't want: professional politicians, not necessarily holding office themselves but overseeing the selection of those who would.
  • This was a system made for corruption, of course, and it violated the founders' vision, but it also fulfilled that vision in a way. The party bosses' power resided in building coalitions that they could serve.
  • The system was corrupt, but it produced leaders like Abraham Lincoln, Theodore Roosevelt, Woodrow Wilson, Franklin Roosevelt, Harry Truman and Dwight Eisenhower, as well as some less illustrious people.
  • Starting in 1972, following Richard Nixon's presidency, the United States shifted away from a system of political bosses. This was achieved by broadly expanding primaries at all levels. Rather than bosses selecting candidates and controlling them, direct democratic elections were used for candidate selection. Since the bosses didn't select candidates, the candidates were beholden to the voters rather than the bosses. Each election year, the voters would select the candidates and then select the officeholder. Over time, the power of the political machine was broken and replaced by a series of elections. The founders did not want this level of democracy, but neither did they explicitly want the party boss.
  • This change had two unanticipated consequences.
  • The first was that the importance of money in the political process surged.
  • Corruption moved from favors for bosses to special treatment of fundraisers, but it was still there.
  • Reformers tried to limit the amount of money that could be contributed, but they ignored two facts.
  • First, a primary system for the presidency is fiendishly expensive simply because delivering the message to the public in 50 states costs a fortune. Second, given the stakes, the desire to influence government is difficult to curb.
  • The second unintended consequence was that it institutionalized political polarization.
  • The founders designed politics to be less important than private life, and in the competition on Election Tuesday, private life tends to win, particularly in off-year elections and primaries.
  • in the primaries, only two types of candidates win. One is the extremely well funded — and the passion of the wings make funding for them even more important. The other is the ideologically committed.
  • All of this applies equally to elections to the House and Senate. It has been said that there has never been less bipartisanship than there is now. I don't know if that is true, but it is certainly the case that the penalties for collaboration with the other party, or for moving to the center, are extremely high.
  • This is not meant to romanticize the bosses. We are, on the whole, better off without them, and we can't resurrect them. I am trying to explain why our elections have become so long, why they cost so much money, and why the wings of the parties get to define agendas and legislative and executive behavior.
  • Geopolitics, as Stratfor uses the concept, argues that the wishes and idiosyncrasies of individual leaders make little difference in the long run. This is because leaders are constrained by global realities. It is also because internal political processes define what must be done to take and hold power. Those internal political processes have their own origins in impersonal forces.
  • There has been a long struggle between the founders' vision of how politics should work and the reality of the process.
  • The American Republic was invented and it is continually being reinvented on the same basic theme. Each reform creates a new form of corruption and a new challenge for governance. In the end, everyone is trapped by reality, but it is taking longer and longer to enter that trap.
  • The political parties emerged against the founders' intentions, because political organization beyond the elite followed from the logic of the government. The rise of political bosses followed from the system, and simultaneously stabilized and corrupted it. The post-Watergate reforms changed the nature of the corruption but also changed the texture of political life. The latter is the issue with which the United States is now struggling.
  • The problem endemic in American culture is the will to reform. It is both the virtue and vice of the U.S. government. It has geopolitical consequences.
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    "We are now in the early phases of selecting the president of the United States. Vast amounts of money are being raised, plans are being laid, opposition research is underway and the first significant scandal has broken with the discovery that Hillary Clinton used a non-government email account for government business. Ahead of us is an extended series of primaries, followed by an election and perhaps a dispute over some aspect of the election. In the United States, the presidential election process takes about two years, particularly when the sitting president cannot run for re-election."
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