His predictions for the fate of print media organisations have proved unnervingly accurate; 2009 would be a bloodbath for newspapers, he warned – and so it came to pass. Dozens of American newspapers closed last year, while several others, such as the Christian Science Monitor, moved their entire operation online. The business model of the traditional print newspaper, according to Shirky, is doomed; the monopoly on news it has enjoyed ever since the invention of the printing press has become an industrial dodo. Rupert Murdoch has just begun charging for online access to the Times – and Shirky is confident the experiment will fail."Everyone's waiting to see what will happen with the paywall – it's the big question. But I think it will underperform. On a purely financial calculation, I don't think the numbers add up." But then, interestingly, he goes on, "Here's what worries me about the paywall. When we talk about newspapers, we talk about them being critical for informing the public; we never say they're critical for informing their customers. We assume that the value of the news ramifies outwards from the readership to society as a whole. OK, I buy that. But what Murdoch is signing up to do is to prevent that value from escaping. He wants to only inform his customers, he doesn't want his stories to be shared and circulated widely. In fact, his ability to charge for the paywall is going to come down to his ability to lock the public out of the conversation convened by the Times."
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Host Cell DNA Residue Detection Kits - 1 views
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Host cell residual DNA refers to the small amount of nucleic acid (host genome, plasmid, or total DNA) that remains in protein drugs expressed and purified through cell culture. During the production process of expressing antibody protein drugs, a large number of cells undergo proliferation and amplification, and some aging cells die and lyse, releasing a large amount of genomic DNA. This leads to the presence of a large amount of free host cell DNA in the cell culture harvest of recombinant biologics, and a small part of the host cell DNA is removed during the processing steps (such as acid precipitation, filtration, etc.), while most of it is removed during the anion exchange chromatography step. Finally, there is a trace amount of host cell residual DNA in the original solution of the recombinant protein drug.
Clay Shirky: 'Paywall will underperform - the numbers don't add up' | Technology | The ... - 0 views
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Cognitive Surplus; Creativity and Generosity in a Connected Age.
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It proves, Shirky argues, that people are more creative and generous than we had ever imagined, and would rather use their free time participating in amateur online activities such as Wikipedia – for no financial reward – because they satisfy the primal human urge for creativity and connectedness.
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"If you are reading this article on a printed copy of the Guardian, what you have in your hand will, just 15 years from now, look as archaic as a Western Union telegram does today. In less than 50 years, according to Clay Shirky, it won't exist at all. The reason, he says, is very simple, and very obvious: if you are 25 or younger, you're probably already reading this on your computer screen. "And to put it in one bleak sentence, no medium has ever survived the indifference of 25-year-olds.""
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