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Gallbladder disease is a sickness for many kinds of conditions that can influence the gallbladder. The gallbladder is a small pear-shaped organ located under the liver that helps store bile developed by the liver and passes the bile to the small intestines to process the fats. Let's explore more about the gallbladder. Most gallbladder disease happens due to inflammation. Inflammation of the gallbladder walls refers to cholecystitis. This irritation mainly happens because of obstruction of the bile duct due to gallstone leading to the bile build up. This condition further leads to necrosis or gangrene.